Opportunity Information: Apply for RFA NS 15 009

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "The NINDS Human Cell and Data Repository (U24)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
  • This funding opportunity was created on Apr 8, 2015 and posted on Apr 8, 2015.
  • Applicants must submit their applications by Jun 9, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
  • Eligible applicants include: Public and State controlled institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Independent school districts Native American tribal governments (Federally recognized) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The grant opportunity RFA-NS-15-009, titled "The NINDS Human Cell and Data Repository (U24)," is a National Institutes of Health (NIH) cooperative agreement designed to grow and strengthen a centralized, widely accessible repository of human cell lines and associated data that support research aligned with the mission of the National Institute of Neurological Disorders and Stroke (NINDS). The main goal is to expand an existing NINDS resource so that it can reliably serve the neuroscience community with high-quality human biospecimen-derived cell models and the information needed to use them effectively in basic, translational, and preclinical research.

At the core of the project is long-term stewardship of an established collection of fibroblast lines and induced pluripotent stem cell (iPSC) lines. In addition to maintaining what already exists, the repository is expected to actively develop new cell resources. That includes generating new iPSC lines and fibroblast cell lines, expanding them to usable quantities, and performing characterization work that verifies identity and quality. The scope also extends to peripheral blood monocyte cells, reflecting an interest in capturing additional, research-relevant immune or blood-derived cellular materials. Where it makes scientific sense, the repository can also genetically modify cell lines, which typically means creating standardized engineered variants (for example, introducing or correcting disease-associated variants, adding reporter constructs, or producing isogenic controls) so researchers can run cleaner comparisons and more reproducible experiments.

A major emphasis of this FOA is broad distribution and utility. The repository is intended to function as a national-level resource that supplies qualified academic and industry investigators with access to these human cell materials, rather than supporting a closed or primarily internal collection. In practice, that implies the award supports infrastructure and operations needed for consistent production, documentation, storage, and dissemination, along with the data systems that allow researchers to understand what a given line is, how it was created, how it performs in quality control, and what conditions or constraints apply to its use.

This opportunity uses the U24 activity code, which signals a cooperative agreement focused on resource-related research and infrastructure where NIH program staff typically have substantial involvement compared to a standard research grant. The funding instrument is listed as a cooperative agreement, and the activity category is health, under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The estimated total funding amount is $1,000,000, and there is no cost sharing or matching requirement.

Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), for-profit organizations (including large for-profit entities and small businesses), and multiple levels of government (state, county, city/township, special district), as well as certain tribal organizations and housing authorities. The announcement also lists a range of eligible institution types such as HBCUs, Hispanic-serving institutions, tribal colleges and universities, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, and eligible federal agencies. Even though some categories mention non-domestic entities in the eligibility list, the FOA explicitly states that non-U.S. (foreign) organizations and foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.

Administratively, the FOA was posted and created on April 8, 2015, with an original and current closing date of June 9, 2015, and an archive date of July 10, 2015. The sponsoring agency is NIH, and the full announcement was made available through the NIH grants guide at the provided link. For technical issues accessing the announcement, the contact point listed is the NIH Office of Extramural Research (OER) webmaster.

FAQs: RFA-NS-15-009 - The NINDS Human Cell and Data Repository (U24)

What is the name and number of this grant opportunity?

The opportunity is RFA-NS-15-009, titled "The NINDS Human Cell and Data Repository (U24)."

Which federal agency is sponsoring this opportunity?

The sponsoring agency is the National Institutes of Health (NIH), supporting a resource aligned with the National Institute of Neurological Disorders and Stroke (NINDS).

What is the main purpose of this cooperative agreement?

The purpose is to grow and strengthen a centralized, widely accessible repository of human cell lines and associated data to support research aligned with the NINDS mission. The repository is intended to reliably serve the neuroscience community with high-quality human biospecimen-derived cell models and the information needed to use them effectively in basic, translational, and preclinical research.

What type of funding mechanism is used?

This funding uses the NIH U24 activity code and is issued as a cooperative agreement. A U24 cooperative agreement is a resource-focused award where NIH program staff typically have substantial involvement compared with a standard research grant.

What is the estimated total funding amount?

The estimated total funding amount is $1,000,000.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement.

What is CFDA 93.853 and how does it relate to this opportunity?

The opportunity is listed under CFDA 93.853, "Extramural Research Programs in the Neurosciences and Neurological Disorders," within the health activity category.

What kinds of biological resources are at the core of the repository?

The core resources include long-term stewardship of an established collection of fibroblast lines and induced pluripotent stem cell (iPSC) lines.

What new resources is the repository expected to develop?

In addition to maintaining existing collections, the repository is expected to actively develop new cell resources, including generating new iPSC lines and fibroblast cell lines, expanding them to usable quantities, and performing characterization to verify identity and quality.

Does the scope include blood-derived or immune-related cell types?

Yes. The scope extends to peripheral blood monocyte cells, reflecting interest in capturing additional research-relevant immune or blood-derived cellular materials.

Is genetic modification of cell lines allowed or expected?

Where it makes scientific sense, the repository can genetically modify cell lines. This typically refers to creating standardized engineered variants, such as introducing or correcting disease-associated variants, adding reporter constructs, or producing isogenic controls to enable cleaner comparisons and more reproducible experiments.

Who is the intended user community for the repository?

The repository is intended to function as a national-level resource serving qualified investigators in both academia and industry.

Is the repository intended to be broadly distributed or mainly for internal use?

A major emphasis is broad distribution and utility. The repository is intended to supply qualified academic and industry investigators with access to the human cell materials, rather than operating as a closed or primarily internal collection.

What kinds of infrastructure and operations does the award support?

The award supports the infrastructure and operations needed for consistent production, documentation, storage, and dissemination of cell materials, along with data systems that allow researchers to understand what a line is, how it was created, how it performed in quality control, and what conditions or constraints apply to its use.

What information is expected to accompany distributed cell lines?

The opportunity emphasizes associated data needed for effective use, including documentation of how a given line was created and quality control information verifying identity and quality, as well as any applicable conditions or constraints on use.

What types of organizations are eligible to apply?

Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), for-profit organizations (including large for-profit entities and small businesses), and multiple levels of government (state, county, city/township, and special district).

Are tribal organizations and housing authorities eligible?

Yes. Certain tribal organizations and housing authorities are listed among eligible applicants.

Are minority-serving institutions and community-based organizations included in the eligible categories?

Yes. The announcement lists a range of eligible institution types, including HBCUs, Hispanic-serving institutions, tribal colleges and universities, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.

Are federal agencies eligible to apply?

Eligible federal agencies are included in the eligibility listing.

Are foreign (non-U.S.) organizations eligible to apply?

No. The FOA explicitly states that non-U.S. (foreign) organizations and foreign institutions are not eligible to apply.

Are non-U.S. components of U.S. organizations eligible?

No. Non-U.S. components of U.S. organizations are not eligible.

Are foreign components allowed under NIH policy for this opportunity?

No. Foreign components (as defined by NIH policy) are not allowed.

When was the FOA posted and created?

The FOA was posted and created on April 8, 2015.

What were the closing date and archive date?

The original and current closing date was June 9, 2015, and the archive date was July 10, 2015.

Where was the full announcement made available?

The full announcement was made available through the NIH grants guide at the link provided in the opportunity information.

Who should be contacted for technical issues accessing the announcement?

For technical issues accessing the announcement, the listed contact is the NIH Office of Extramural Research (OER) webmaster.

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