Opportunity Information: Apply for RFA HL 10 002
Apply for RFA HL 10 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Role of Cardiomyocyte Mitochondria in Heart Disease An Integrated Approach (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Sep 26, 2008 and posted on Sep 26, 2008.
- Applicants must submit their applications by May 19, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) State governments Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Special district governments For profit organizations other than small businesses Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, released this Funding Opportunity Announcement (FOA) to support research that clarifies how mitochondria inside cardiomyocytes (heart muscle cells) influence the way the heart adapts to stress and how heart disease progresses over time. The central idea is to move beyond isolated measurements and instead build an integrated, systems-level understanding of cardiomyocyte mitochondria by combining traditional functional experiments with data generated from newer, high-powered technologies. In practice, the FOA is looking for collaborative projects that can connect mitochondrial behavior (such as energy production, signaling, oxidative stress handling, cell death pathways, and metabolic remodeling) to real myocardial outcomes relevant to disease development and progression.
This opportunity uses the NIH R01 mechanism, meaning it is intended for substantial, hypothesis-driven research projects rather than small pilot studies. The emphasis on an "integrated approach" signals that applications are expected to bring together complementary expertise or methods, for example pairing physiology and mitochondrial functional assays with technology-driven datasets (such as omics, advanced imaging, or other emerging platforms) to create a more complete picture of mitochondrial roles in heart disease. The overall goal is not simply to generate descriptive datasets, but to connect those datasets to functional understanding of how mitochondrial changes contribute to myocardial adaptation and the transition toward pathology.
NHLBI indicated an intention to commit about $4,000,000 in total costs in fiscal year 2010 for this initiative, with total spending potentially reaching up to $16,000,000 over four years. The institute anticipated funding up to six awards under this FOA, with the standard NIH caveat that final awards depend on the availability of funds and the receipt of a sufficient number of scientifically strong, meritorious applications. The FOA is listed under the discretionary category and is aligned with the health funding activity area, specifically CFDA 93.837 (Cardiovascular Diseases Research). There is no cost sharing or matching requirement.
Eligibility is broad and includes many types of organizations that can conduct biomedical research. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, excluding higher education where specified), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also allows applications from groups such as federally recognized and other tribal governments and tribal organizations, Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and eligible federal agencies. Importantly, the eligibility list also includes non-domestic (non-U.S.) entities (foreign organizations), which indicates that international institutions could apply, consistent with NIH policies when permitted by the announcement.
Key administrative details include the Funding Opportunity Number RFA-HL-10-002, with an original posting date of September 26, 2008. The closing date for applications was May 19, 2009, and the opportunity was later archived on June 19, 2009. The official announcement and full requirements were provided through the NIH Grants Guide (linked in the source data), and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is the purpose of this Funding Opportunity Announcement (FOA)?
This FOA from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), supports research to clarify how mitochondria inside cardiomyocytes (heart muscle cells) influence how the heart adapts to stress and how heart disease progresses over time.
What scientific focus does the FOA emphasize?
The FOA emphasizes building an integrated, systems-level understanding of cardiomyocyte mitochondria rather than relying on isolated measurements. The intent is to connect mitochondrial behavior to myocardial outcomes that matter for disease development and progression.
What types of mitochondrial behaviors are specifically highlighted in the FOA?
The FOA highlights mitochondrial behavior such as energy production, signaling, oxidative stress handling, cell death pathways, and metabolic remodeling, and encourages linking these processes to real myocardial outcomes relevant to heart disease.
What does NHLBI mean by an "integrated approach" in this FOA?
An "integrated approach" signals that projects are expected to combine complementary methods and/or expertise. Examples given include pairing traditional physiology and mitochondrial functional assays with technology-driven datasets such as omics, advanced imaging, or other emerging platforms to create a more complete picture of mitochondrial roles in heart disease.
Is the FOA looking for descriptive dataset generation only?
No. The FOA states that the goal is not simply to generate descriptive datasets. Applications are expected to connect those datasets to functional understanding of how mitochondrial changes contribute to myocardial adaptation and the transition toward pathology.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which is intended for substantial, hypothesis-driven research projects.
Is this FOA intended for small pilot studies?
The FOA is framed around the NIH R01 mechanism and is described as intended for substantial, hypothesis-driven research projects rather than small pilot studies.
Does the FOA encourage collaborative projects?
Yes. The FOA is described as seeking collaborative projects that can connect mitochondrial function and behavior to myocardial outcomes relevant to disease development and progression.
What is the Funding Opportunity Number for this FOA?
The Funding Opportunity Number is RFA-HL-10-002.
Which NIH institute released this FOA?
The FOA was released by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH).
How much funding did NHLBI plan to commit for this initiative?
NHLBI indicated an intention to commit about $4,000,000 in total costs in fiscal year 2010 for this initiative, with total spending potentially reaching up to $16,000,000 over four years.
How many awards did NHLBI anticipate funding under this FOA?
NHLBI anticipated funding up to six awards, with the standard NIH caveat that final awards depend on the availability of funds and the receipt of a sufficient number of scientifically strong, meritorious applications.
Are awards guaranteed if an application is submitted?
No. The FOA notes that awards depend on the availability of funds and on receiving a sufficient number of meritorious applications.
Is cost sharing or matching required?
No. The FOA states that there is no cost sharing or matching requirement.
What is the CFDA number and program area associated with this FOA?
The FOA is aligned with the health funding activity area and is listed under CFDA 93.837 (Cardiovascular Diseases Research).
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (including those with and without 501(c)(3) status, excluding higher education where specified); and for-profit organizations (including small businesses and other for-profits).
Are government entities eligible to apply?
Yes. Eligible applicants include many government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list includes federally recognized and other tribal governments and tribal organizations.
Are minority-serving institutions and similar organizations included in eligibility?
Yes. The eligibility list includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included in the eligibility list.
Are U.S. territories or regional organizations eligible?
Yes. The eligibility list includes U.S. territories or possessions and regional organizations.
Are federal agencies eligible to apply?
Yes. The eligibility list includes eligible federal agencies.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list explicitly includes non-domestic (non-U.S.) entities (foreign organizations), indicating that international institutions could apply, consistent with NIH policies when permitted by the announcement.
What is the original posting date for the FOA?
The original posting date was September 26, 2008.
What was the application closing date?
The closing date for applications was May 19, 2009.
When was the opportunity archived?
The opportunity was archived on June 19, 2009.
Where were the official announcement and full requirements provided?
The official announcement and full requirements were provided through the NIH Grants Guide (as referenced in the source information).
Who is listed as the contact for technical access issues?
Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
How is this FOA categorized?
The FOA is listed under the discretionary category and aligned with the health funding activity area.
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