Opportunity Information: Apply for RFA HL 17 017
Apply for RFA HL 17 017
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "The Role of Dysbiosis in Cardiovascular, Pulmonary and Hematological Complications During HIV Infection (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on Jul 11, 2016.
- Applicants must submit their applications by Nov 08, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $310,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "The Role of Dysbiosis in Cardiovascular, Pulmonary and Hematological Complications During HIV Infection (R01)" (Funding Opportunity Number RFA-HL-17-017) is a National Institutes of Health (NIH) research project grant meant to push forward basic, mechanistic science on how HIV-associated changes in the microbiome may drive serious non-AIDS complications. The central idea is that HIV infection can disrupt the normal balance of microbial communities (dysbiosis), and that this imbalance may trigger or worsen co-morbid conditions affecting the heart, lungs, and blood (often abbreviated as HLB). The announcement is framed around building a strong biological foundation that can later support early translational work, meaning it is primarily about uncovering causes, pathways, and mechanisms rather than immediately testing clinical interventions. It explicitly includes both adult and pediatric HIV populations, reflecting interest in how these processes may differ across age groups and stages of development.
From a scientific scope standpoint, the FOA emphasizes mechanistic investigations that can explain how dysbiosis emerges during HIV infection and how it connects to cardiovascular disease, pulmonary disease, and hematological abnormalities. The intended studies can use a wide range of experimental and computational systems, including in vitro approaches (cell culture and controlled laboratory assays), in vivo models (animal models or other whole-organism systems), ex vivo work (experiments performed on tissues or cells taken from organisms and studied outside the body), and in silico modeling (bioinformatics, computational modeling, and analysis of complex multi-omic datasets). In practice, this invites proposals that might, for example, link microbial shifts to immune activation, inflammation, endothelial dysfunction, coagulation changes, altered metabolites, or microbial translocation and barrier disruption, then trace how those processes contribute to heart, lung, or blood complications seen in people living with HIV.
A major theme of the opportunity is multidisciplinary collaboration, particularly because microbiome research at a mechanistic level often requires combining clinical insight with microbial ecology, immunology, and advanced measurement and analytics. The FOA encourages teams spanning cardiology, pulmonology, hematology, immunology, infectious diseases, microbiology, biotechnology, bioinformatics, and "-omic" sciences (such as genomics, transcriptomics, proteomics, metabolomics, and metagenomics). This is consistent with the reality that teasing apart dysbiosis-related mechanisms usually involves integrating microbial community profiling with host-response measures, functional assays, and sophisticated computational analyses to move beyond correlation toward causation.
On the administrative side, this is a discretionary grant funding opportunity under the U.S. Department of Health and Human Services, administered by NIH, and categorized as a health-related funding activity. The referenced CFDA numbers include 93.233 and several 93.83x programs (93.837, 93.838, 93.839, 93.840), indicating alignment with NIH institutes and programs that support heart, lung, blood, and related biomedical research. The listed award ceiling is $310,000, and the expected number of awards is 5, suggesting a relatively competitive program designed to fund a small set of focused projects aligned with the HIV Microbiome Centers concept.
Eligibility is broad and includes many organization types: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (outside of universities); for-profit organizations (other than small businesses); small businesses; and other applicants as clarified in the full eligibility text. The opportunity was created on July 11, 2016, with an original closing date of November 8, 2016, indicating this specific FOA cycle is historic, but the summary still captures NIH priorities and the kind of mechanistic microbiome-and-HIV work the agency sought to catalyze at that time.
Overall, the FOA is designed to strengthen the basic science needed to understand why people living with HIV can experience elevated risks of cardiovascular, pulmonary, and hematological complications even in the era of effective antiretroviral therapy. By focusing on HIV-induced dysbiosis and the downstream biological pathways that may connect microbial imbalance to HLB disease, the program aims to generate actionable mechanistic insights that can later inform biomarker development, risk stratification, and the earliest stages of translational strategies to prevent or mitigate HIV-related HLB co-morbidities.
Frequently Asked Questions (FAQs)
What is the official title and funding opportunity number for this grant?
The opportunity is titled "The Role of Dysbiosis in Cardiovascular, Pulmonary and Hematological Complications During HIV Infection (R01)" and the Funding Opportunity Number is RFA-HL-17-017.
What type of grant mechanism is being offered?
This is an NIH Research Project Grant (R01) opportunity intended to support hypothesis-driven research projects.
Which federal agency is administering this opportunity?
The program is administered by the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services.
What is the main scientific focus of the FOA?
The FOA focuses on basic, mechanistic science examining how HIV-associated dysbiosis (disruption of normal microbial community balance) may contribute to cardiovascular, pulmonary, and hematological (HLB) complications during HIV infection.
What does "dysbiosis" mean in the context of this funding opportunity?
In this FOA, dysbiosis refers to HIV-associated alterations in the microbiome that disrupt the typical balance of microbial communities, potentially triggering or worsening downstream biological processes linked to heart, lung, and blood complications.
What kinds of health complications are included under "HLB" in this announcement?
HLB refers to cardiovascular disease (heart-related conditions), pulmonary disease (lung-related conditions), and hematological abnormalities (blood-related disorders or dysfunction).
Is the FOA focused on basic research or clinical intervention testing?
The FOA is primarily focused on building a strong mechanistic and biological foundation. It is framed to support basic studies that can later enable early translational work, rather than immediately testing clinical interventions.
Are both adult and pediatric HIV populations included in the scientific scope?
Yes. The FOA explicitly includes both adult and pediatric HIV populations, reflecting interest in potential differences by age group and developmental stage.
What kinds of study approaches and systems are encouraged?
The FOA supports a wide range of experimental and computational approaches, including:
- In vitro studies (cell culture and controlled laboratory assays)
- In vivo studies (animal models or other whole-organism systems)
- Ex vivo studies (tissues or cells taken from organisms and studied outside the body)
- In silico studies (bioinformatics, computational modeling, and analysis of complex multi-omic datasets)
What types of mechanistic questions does the FOA prioritize?
The FOA prioritizes mechanistic investigations that explain how dysbiosis emerges during HIV infection and how it connects to cardiovascular, pulmonary, and hematological complications.
What are examples of biological pathways or processes that may be relevant to proposed projects?
Examples described in the opportunity include linking microbiome shifts to immune activation, inflammation, endothelial dysfunction, coagulation changes, altered metabolites, microbial translocation, and barrier disruption, then tracing how those processes contribute to HLB complications in people living with HIV.
Does the FOA encourage multidisciplinary or collaborative teams?
Yes. A major theme is multidisciplinary collaboration, recognizing that mechanistic microbiome research often requires combining clinical expertise with microbial ecology, immunology, advanced measurement methods, and sophisticated analytics.
Which scientific and clinical disciplines are specifically called out as relevant?
The FOA highlights a broad, multidisciplinary mix that may include cardiology, pulmonology, hematology, immunology, infectious diseases, microbiology, biotechnology, bioinformatics, and "-omic" sciences such as genomics, transcriptomics, proteomics, metabolomics, and metagenomics.
What is the maximum award amount (award ceiling) mentioned?
The listed award ceiling is $310,000.
How many awards are expected under this opportunity?
The FOA indicates an expected number of awards of 5, suggesting a competitive program funding a relatively small set of aligned projects.
What CFDA program numbers are referenced?
The summary references CFDA 93.233 and several 93.83x programs, including 93.837, 93.838, 93.839, and 93.840.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities / Indian housing authorities
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
- Other applicants as clarified in the full eligibility text
When was this funding opportunity created and when did it close?
The opportunity was created on July 11, 2016, and the original closing date listed is November 8, 2016.
Is this FOA still open for applications?
Based on the provided dates (closing date of November 8, 2016), this specific FOA cycle appears to be historic rather than currently open.
What is the broader purpose or rationale behind this FOA?
The FOA is designed to strengthen the mechanistic science needed to understand why people living with HIV can experience elevated risks of cardiovascular, pulmonary, and hematological complications, even in the era of effective antiretroviral therapy, by focusing on HIV-induced dysbiosis and the downstream pathways connecting microbial imbalance to HLB disease.
What kinds of downstream impacts does the FOA suggest this research could support later on?
The announcement suggests that mechanistic insights generated by these projects could later inform biomarker development, risk stratification, and early-stage translational strategies aimed at preventing or mitigating HIV-related HLB co-morbidities.
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