Opportunity Information: Apply for RFA ES 13 011
Apply for RFA ES 13 011
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "The Role of Environmental Exposures in the Development of Autoimmune Disease (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health.
- This funding opportunity was created on Aug 6, 2013 and posted on Aug 6, 2013.
- Applicants must submit their applications by Nov 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,400,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Independent school districts Small businesses For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments County governments Public and State controlled institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The grant opportunity "The Role of Environmental Exposures in the Development of Autoimmune Disease (R21)" (Funding Opportunity Number RFA-ES-13-011) is a National Institutes of Health (NIH) funding announcement in the environmental health area (CFDA 93.113). It is structured as an R21, meaning it is intended for exploratory, early-stage, or proof-of-concept research rather than large, fully developed programs. The central goal is to stimulate innovative studies that clarify how environmental exposures contribute to the development of autoimmune disease and/or worsen (exacerbate) existing autoimmune conditions. The program is positioned to support mechanistic work that can build a stronger foundation for later human-focused research, including surveillance or epidemiologic follow-up.
This opportunity specifically encourages projects that examine environmental exposures suspected or known to be linked with autoimmune-related outcomes in humans, and then test biological plausibility and causality using controlled experimental systems. Applicants are invited to use in vitro approaches (cell culture and related laboratory systems) and/or animal models to investigate the mechanisms by which exposures might trigger an autoimmune response or drive progression to autoimmune disease. The emphasis is not just on showing that an exposure has an effect, but on unpacking the underlying pathways and immune processes that connect an exposure to immune dysregulation, loss of tolerance, inflammation, and tissue damage typical of autoimmune pathology.
NIH highlights three particularly important research angles. First, the announcement prioritizes studies that can identify and characterize "critical windows" of susceptibility, meaning life stages or time periods when exposure may have an outsized impact on autoimmune risk or severity (for example, prenatal development, early childhood, puberty, pregnancy, or other hormonally and immunologically dynamic periods). Second, it encourages research on mechanisms that might explain gender differences in autoimmune disease development and response to environmental triggers, reflecting the well-known sex bias in many autoimmune diseases and the possibility that hormones, genetics, and immune regulation interact with exposure-related effects. Third, it supports studies that can generate potential biomarkers, with the idea that biomarkers emerging from mechanistic models could later be adapted for human monitoring, early detection, exposure tracking, or risk stratification in subsequent surveillance studies.
From an administrative and funding standpoint, this is a discretionary grant program with an estimated total funding amount of $2,400,000. The award ceiling is listed as $200,000. There is no cost sharing or matching requirement. The opportunity was posted and created on August 6, 2013, with an original and current closing date of November 15, 2013, and an archive date of December 16, 2013, indicating the solicitation is no longer open but remains relevant as a reference for the type of research NIH sought to stimulate.
Eligibility is broad across U.S.-based organizations and includes state, county, city/township, and special district governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; small businesses; for-profit organizations (including those other than small businesses); independent school districts; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations (including federally recognized entities and other tribal organizations). The announcement also clarifies additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign institutions are not eligible to apply, and foreign components of U.S. organizations are not allowed under the NIH definition referenced in the NIH Grants Policy Statement.
For applicants or readers seeking the full official text, NIH provided an additional information link to the archived funding announcement page (http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-13-011.html). For technical access issues, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the NIH funding announcement titled "The Role of Environmental Exposures in the Development of Autoimmune Disease (R21)" with Funding Opportunity Number RFA-ES-13-011 (CFDA 93.113). It focuses on environmental health research related to autoimmune disease.
What is the main goal of the grant?
The central goal is to stimulate innovative, early-stage studies that clarify how environmental exposures contribute to the development of autoimmune disease and/or worsen existing autoimmune conditions. The program emphasizes mechanistic research that can strengthen the foundation for later human-focused research such as surveillance or epidemiologic follow-up.
What does "R21" mean for this opportunity?
R21 indicates an exploratory/developmental grant mechanism. It is intended for exploratory, early-stage, or proof-of-concept research rather than large, fully developed research programs.
What kinds of research approaches are encouraged?
The announcement encourages controlled experimental studies that test biological plausibility and causality, using in vitro approaches (such as cell culture and related laboratory systems) and/or animal models to investigate mechanisms linking exposures to autoimmune-related outcomes.
Does the opportunity focus on human studies?
The emphasis described is on mechanistic work in controlled experimental systems (in vitro and/or animal models). The intent is to build a stronger foundation for later human-focused research, including potential surveillance or epidemiologic follow-up.
What types of environmental exposures are relevant?
Projects are encouraged to examine environmental exposures that are suspected or known to be linked with autoimmune-related outcomes in humans, and then investigate mechanisms and causality in controlled experimental systems.
Is the goal simply to show an exposure has an effect?
No. The emphasis is not just on demonstrating an effect, but on unpacking the underlying pathways and immune processes that connect an exposure to immune dysregulation, loss of tolerance, inflammation, and tissue damage typical of autoimmune pathology.
What specific scientific themes does NIH highlight as priorities?
NIH highlights three particularly important research angles: (1) identifying and characterizing "critical windows" of susceptibility; (2) investigating mechanisms that could explain gender differences in autoimmune disease development and response to environmental triggers; and (3) generating potential biomarkers from mechanistic models that could later be adapted for human monitoring and related uses.
What are "critical windows" of susceptibility in this context?
"Critical windows" refer to life stages or time periods when exposure may have an outsized impact on autoimmune risk or disease severity. Examples provided include prenatal development, early childhood, puberty, pregnancy, or other hormonally and immunologically dynamic periods.
How does this opportunity address gender differences in autoimmune disease?
It encourages research on mechanisms that might explain gender differences in autoimmune disease development and responses to environmental triggers, reflecting the sex bias seen in many autoimmune diseases and the possibility that hormones, genetics, and immune regulation interact with exposure-related effects.
Are biomarker-related studies within scope?
Yes. The opportunity supports studies that can generate potential biomarkers, with the idea that biomarkers emerging from mechanistic models could later be adapted for human monitoring, early detection, exposure tracking, or risk stratification in subsequent surveillance studies.
What is the estimated total funding available under this announcement?
The estimated total funding amount listed is $2,400,000.
What is the maximum award amount (award ceiling)?
The award ceiling is listed as $200,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
When was this opportunity posted, and what are the key dates?
The opportunity was posted and created on August 6, 2013. The original and current closing date is November 15, 2013. The archive date is December 16, 2013.
Is this funding opportunity still open?
No. Based on the closing date (November 15, 2013) and archive date (December 16, 2013), the solicitation is no longer open and remains available as an archived reference.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations. Eligible applicants include state, county, city/township, and special district governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; small businesses; for-profit organizations (including those other than small businesses); independent school districts; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations (including federally recognized entities and other tribal organizations).
Are specific institution types (like HBCUs or Hispanic-serving institutions) eligible?
Yes. The announcement explicitly notes additional eligible applicants such as HBCUs, Hispanic-serving institutions, TCCUs, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs, as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Are foreign components of U.S. organizations allowed?
No. The announcement states that foreign components of U.S. organizations are not allowed under the NIH definition referenced in the NIH Grants Policy Statement.
Where can someone find the official archived announcement text?
The archived NIH funding announcement is available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-13-011.html
Who should be contacted for technical access issues?
For technical access issues, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants who have applied for this opportunity (RFA ES 13 011) also looked into and applied for these:
| Funding Opportunity |
|---|
| Validation and Demonstration of Devices for Environmental Exposure Assessment (R21/R33) Apply for RFA ES 13 013 Funding Number: RFA ES 13 013 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Outstanding New Environmental Scientist (ONES) Award (R01) Apply for RFA ES 13 014 Funding Number: RFA ES 13 014 Agency: National Institutes of Health Category: Environment Health Funding Amount: $250,000 |
| Environmental Health Sciences Core Centers (EHS CC) (P30) Apply for RFA ES 13 012 Funding Number: RFA ES 13 012 Agency: National Institutes of Health Category: Environment Health Funding Amount: $1,300,000 |
| NIH Revision Awards for Creating Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER)(R01) Apply for PAR 14 050 Funding Number: PAR 14 050 Agency: National Institutes of Health Category: Environment Health Funding Amount: $250,000 |
| Developing Mercury Inventories for Artisanal and Small scale Gold Mining Sectors in Southeast Asia Apply for OES OMM 14 001 Funding Number: OES OMM 14 001 Agency: Ocean and International Environmental Scientific Category: Environment Health Funding Amount: $200,000 |
| Novel Technologies for Rapid and Sensitive Biomonitoring in Humans (R43/R44) Apply for RFA ES 14 005 Funding Number: RFA ES 14 005 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| SBIR E learning for HAZMAT and Emergency Response (R43/R44) Apply for RFA ES 14 003 Funding Number: RFA ES 14 003 Agency: National Institutes of Health Category: Environment Health Funding Amount: $100,000 |
| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25) Apply for RFA ES 14 004 Funding Number: RFA ES 14 004 Agency: National Institutes of Health Category: Environment Health Funding Amount: $100,000 |
| Innovative Approaches for the Identification of Mitochondria Cell Signaling Networks in Response to Environmental Stress Apply for RFA ES 14 006 Funding Number: RFA ES 14 006 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Hazmat Training at DOE Nuclear Weapons Complex (UH4) Apply for RFA ES 14 009 Funding Number: RFA ES 14 009 Agency: National Institutes of Health Category: Environment Health Funding Amount: $700,000 |
| Hazardous Materials Worker Health and Safety Training (U45) Apply for RFA ES 14 008 Funding Number: RFA ES 14 008 Agency: National Institutes of Health Category: Environment Health Funding Amount: $700,000 |
| Childrens Environmental Health and Disease Prevention Research Centers (P50) Apply for RFA ES 14 002 Funding Number: RFA ES 14 002 Agency: National Institutes of Health Category: Environment Health Funding Amount: $1,500,000 |
| Outstanding New Environmental Scientist (ONES) Award (R01) Apply for RFA ES 15 003 Funding Number: RFA ES 15 003 Agency: National Institutes of Health Category: Environment Health Funding Amount: $475,000 |
| Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (R41) Apply for RFA ES 15 005 Funding Number: RFA ES 15 005 Agency: National Institutes of Health Category: Environment Health Funding Amount: $225,000 |
| Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (R43/R44) Apply for RFA ES 15 006 Funding Number: RFA ES 15 006 Agency: National Institutes of Health Category: Environment Health Funding Amount: $225,000 |
| Environmental Health Sciences Core Centers (EHS CC) (P30) Apply for RFA ES 15 007 Funding Number: RFA ES 15 007 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Collaborative Activities to promote High Dimensional Molecular Analyses in NIEHS supported Childrens Environmental Health Studies (Admin Supp) Apply for PA 15 123 Funding Number: PA 15 123 Agency: National Institutes of Health Category: Environment Health Funding Amount: $300,000 |
| Childrens Health Exposure Analysis Resource (CHEAR) National Exposure Assessment Laboratory Network (U2C) Apply for RFA ES 15 009 Funding Number: RFA ES 15 009 Agency: National Institutes of Health Category: Environment Health Funding Amount: $8,000,000 |
| Childrens Health Exposure Analysis Resource (CHEAR) Data Repository, Analysis and Science Center (U2C) Apply for RFA ES 15 010 Funding Number: RFA ES 15 010 Agency: National Institutes of Health Category: Environment Health Funding Amount: $6,000,000 |
| Childrens Health Exposure Analysis Resource (CHEAR) Coordinating Center (U24) Apply for RFA ES 15 011 Funding Number: RFA ES 15 011 Agency: National Institutes of Health Category: Environment Health Funding Amount: $3,300,000 |
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