Opportunity Information: Apply for RFA MH 16 110
Apply for RFA MH 16 110
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Role of Exosomes in HIV Neuropathogenesis (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Mar 20, 2015 and posted on Mar 20, 2015.
- Applicants must submit their applications by Sep 2, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Independent school districts Special district governments Public housing authorities/Indian housing authorities County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education City or township governments Private institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "The Role of Exosomes in HIV Neuropathogenesis (R21)" (Funding Opportunity Number RFA-MH-16-110) is an NIH discretionary grant solicitation that supports small, exploratory research projects aimed at clarifying how exosomes contribute to HIV-1 Associated Neurocognitive Disorders (HAND). The core scientific focus is on defining the central role exosomes may play in HIV-related damage and dysfunction in the central nervous system (CNS), and on evaluating whether exosomes can be leveraged either as measurable biomarkers for HAND or as practical delivery vehicles for CNS-targeted therapies. The announcement emphasizes both basic and translational research, meaning projects can range from fundamental mechanistic studies of exosome biology in HIV neuropathogenesis to more applied work that tests diagnostic or therapeutic concepts. Research may be conducted in domestic or international settings, and while multidisciplinary teams and collaborations are encouraged, they are not mandatory.
From a programmatic standpoint, the FOA uses the R21 mechanism, which is typically intended for early-stage, high-impact, proof-of-concept studies rather than large, long-term clinical trials. The award ceiling listed is $200,000, and there is no cost sharing or matching requirement. The opportunity falls under NIH health research activity areas and is associated with CFDA numbers 93.242 (Mental Health Research Grants) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders), reinforcing that the work is expected to sit at the intersection of neurobiology, virology, and neurocognitive/mental health outcomes.
A wide range of applicant organizations are eligible. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, and for-profit organizations other than small businesses, along with numerous governmental entities such as state governments, county governments, city or township governments, special district governments, and independent school districts. The eligibility language also explicitly includes tribal governments (federally recognized and other than federally recognized) and tribal colleges and universities, as well as U.S. territories or possessions. Beyond these standard categories, the FOA lists additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, AANAPISI institutions, faith-based or community-based organizations, eligible federal agencies, regional organizations, and non-U.S. entities (foreign organizations). In practical terms, this indicates NIH intended the scientific community broadly defined, including international partners, to be able to pursue exosome-focused HAND research under this call.
Timing details in the source information indicate the FOA was posted on March 20, 2015, with an original and current closing date of September 2, 2015, and an archive date of October 3, 2015, meaning this specific announcement is no longer open for new applications. The sponsoring agency is the National Institutes of Health, and the full announcement was hosted through the NIH grants guide. Contact information provided is primarily logistical, directing applicants to the NIH Office of Extramural Research (OER) webmaster for technical access issues related to the online posting.
In short, this R21 opportunity was designed to stimulate innovative, smaller-scale studies that could clarify whether exosomes are key drivers or mediators of HIV-related neurocognitive injury and whether exosome-based measurements or engineered exosome platforms could improve how HAND is detected, monitored, or treated, especially with approaches capable of reaching the CNS.
Frequently Asked Questions (FAQs)
1) What is the title and funding opportunity number for this grant?
The opportunity is titled "The Role of Exosomes in HIV Neuropathogenesis (R21)" and the Funding Opportunity Number is RFA-MH-16-110.
2) What agency is sponsoring this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
3) What type of grant mechanism does this FOA use?
This FOA uses the NIH R21 mechanism, which is generally intended for small, exploratory, proof-of-concept, and potentially high-impact research projects.
4) What is the overall scientific purpose of this FOA?
The FOA supports exploratory research projects aimed at clarifying how exosomes contribute to HIV-1 Associated Neurocognitive Disorders (HAND), with emphasis on understanding exosomes in HIV-related damage and dysfunction in the central nervous system (CNS).
5) What specific research themes or questions does the FOA emphasize?
It emphasizes defining the central role exosomes may play in HIV neuropathogenesis and evaluating whether exosomes can be used as measurable biomarkers for HAND or as delivery vehicles for CNS-targeted therapies.
6) Does this FOA support basic research, translational research, or both?
Both. The announcement explicitly emphasizes basic and translational research, ranging from mechanistic studies of exosome biology in HIV neuropathogenesis to applied testing of diagnostic or therapeutic concepts.
7) Is the focus specifically on the central nervous system (CNS)?
Yes. A core focus is HIV-related damage and dysfunction in the CNS and how exosomes may contribute to that process in relation to HAND.
8) Is the grant specifically tied to HIV-1 Associated Neurocognitive Disorders (HAND)?
Yes. The FOA is oriented around understanding exosomes in the context of HAND and HIV-related neurologic and neurocognitive outcomes.
9) Are projects expected to be large clinical trials?
No. Based on the R21 mechanism description provided, this opportunity is framed as supporting early-stage, high-impact, proof-of-concept studies rather than large, long-term clinical trials.
10) What is the maximum award amount listed in the information provided?
The award ceiling listed is $200,000.
11) Is cost sharing or matching required?
No. The information provided states there is no cost sharing or matching requirement.
12) Where can the research be conducted?
Research may be conducted in domestic or international settings.
13) Are collaborations or multidisciplinary teams required?
No. Multidisciplinary teams and collaborations are encouraged, but they are not mandatory.
14) What types of applicant organizations are eligible?
A wide range of organizations are eligible, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), small businesses, and for-profit organizations other than small businesses, as well as multiple governmental entity types.
15) Which governmental entities are listed as eligible applicants?
Eligible governmental entities include state governments, county governments, city or township governments, special district governments, and independent school districts.
16) Are tribal governments and tribal institutions eligible?
Yes. The eligibility language explicitly includes tribal governments (federally recognized and other than federally recognized) and tribal colleges and universities.
17) Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly included in the eligibility list.
18) Are foreign (non-U.S.) organizations eligible?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations) as eligible applicants.
19) Are minority-serving institutions specifically named as eligible?
Yes. The eligibility list explicitly names Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions.
20) Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are specifically listed as eligible applicants.
21) Are federal agencies or regional organizations eligible?
Yes. The eligibility list includes eligible federal agencies and regional organizations.
22) What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.242 (Mental Health Research Grants) and CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
23) What does the CFDA association suggest about the scientific area?
Based on the CFDA numbers provided, the opportunity sits at the intersection of mental health/neurocognitive outcomes and neurosciences/neurological disorders, alongside the virology and neurobiology implied by the HIV and exosome focus.
24) When was this FOA posted, and what were the closing and archive dates?
The FOA was posted on March 20, 2015. The original and current closing date listed is September 2, 2015. The archive date is October 3, 2015.
25) Is this funding opportunity currently open for new applications?
No. Based on the provided closing and archive dates, this specific announcement is no longer open for new applications.
26) Where was the full announcement hosted?
The full announcement was hosted through the NIH grants guide.
27) What contact information is provided in the source information?
The contact information provided is primarily logistical, directing applicants to the NIH Office of Extramural Research (OER) webmaster for technical access issues related to the online posting.
28) What kinds of outcomes or impacts is NIH trying to stimulate through this R21?
The FOA is designed to stimulate innovative, smaller-scale studies that clarify whether exosomes are key drivers or mediators of HIV-related neurocognitive injury and whether exosome-based measurements or engineered exosome platforms could improve detection, monitoring, or treatment of HAND, including approaches capable of reaching the CNS.
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