Opportunity Information: Apply for PA 13 197
Apply for PA 13 197
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Role of Extracellular RNA in Mediating the Health Effects of Alcohol (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Apr 15, 2013 and posted on Apr 15, 2013.
- Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Independent school districts Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities State governments Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The grant opportunity titled "The Role of Extracellular RNA in Mediating the Health Effects of Alcohol (R21)" (Funding Opportunity Number PA 13-197) is an NIH discretionary research grant aimed at sparking new, exploratory projects that investigate how extracellular RNA (exRNA) contributes to alcohol-related disease. The focus is on innovative, early-stage studies that can open up new directions or generate convincing preliminary evidence, rather than large, fully mature research programs. In this announcement, exRNA means RNA molecules that are found outside cells in circulation, either packaged inside vesicles (such as extracellular vesicles) or bound to carrier molecules. The central idea behind the FOA is that these circulating RNAs can function as signals between cells and organs, potentially shaping biological responses to alcohol exposure across the body.
Scientifically, the opportunity targets the role of exRNA-based communication in the initiation, progression, and persistence of medical problems caused by excessive and long-term alcohol consumption. Alcohol can damage multiple organs and systems, and the FOA is built around the premise that exRNAs may be part of the mechanism by which alcohol drives inflammation, tissue injury, immune dysregulation, metabolic changes, and other pathological processes that lead to end-organ damage. By supporting studies that clarify what exRNAs are released after alcohol exposure, where they come from, how they travel, which cells receive them, and what gene-regulatory effects they trigger, NIH is seeking data that could meaningfully change how researchers understand alcohol-induced pathology across diverse diseases rather than in isolated organ-specific silos.
A major expected payoff is translational. If certain exRNA signatures reliably track alcohol exposure, disease stage, or organ injury, they could become useful biomarkers for diagnosis, risk stratification, monitoring disease progression, or measuring response to treatment. Likewise, if specific exRNAs are shown to be causal drivers of injury pathways, they could point to therapeutic strategies, such as blocking harmful vesicle signaling, modifying exRNA packaging and release, or targeting downstream pathways activated by exRNA uptake. The FOA also explicitly leaves room for research that addresses a different but related question: the mechanistic basis of the reported health effects sometimes associated with moderate alcohol consumption. In other words, the same exRNA communication framework might help explain not only harmful outcomes from chronic heavy use but also biological responses that could underlie any protective associations observed in certain contexts.
From an administrative standpoint, this is an NIH grant using the R21 mechanism, which is typically used for exploratory and developmental research that is potentially high-impact but still at an early stage. The listed award ceiling is $200,000, and there is no cost-sharing or matching requirement. The activity category is Health, and it aligns with CFDA number 93.273 (Alcohol Research Programs). The opportunity was posted on April 15, 2013, with an original and final closing date of May 7, 2016, and an archive date of June 7, 2016, meaning it is no longer open for new applications under that specific announcement, though similar topics may appear in newer NIH funding opportunities.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, independent school districts, and various levels of government (city/township, county, state, special district). It also extends to tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and additional categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, and faith-based or community-based organizations. Importantly, non-U.S. entities are eligible as well: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by NIH policy are allowed. The sponsoring agency is the National Institutes of Health, and the full announcement was hosted on the NIH grants site at the link provided in the source data.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "The Role of Extracellular RNA in Mediating the Health Effects of Alcohol (R21)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA 13-197.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is this?
This opportunity uses the NIH R21 mechanism, which is designed for exploratory and developmental research projects.
What is the main purpose of the R21 mechanism in this FOA?
The R21 mechanism here is intended to spark new, innovative, early-stage research that can open new directions or generate convincing preliminary evidence, rather than support large, fully mature research programs.
What does "extracellular RNA (exRNA)" mean in this announcement?
In this FOA, exRNA refers to RNA molecules found outside cells in circulation. These RNAs may be packaged inside vesicles (such as extracellular vesicles) or bound to carrier molecules.
What is the central scientific idea behind the FOA?
The FOA is built around the idea that circulating exRNAs can act as signals between cells and organs, potentially influencing biological responses to alcohol exposure across the body.
What research focus does the FOA prioritize?
The FOA targets research on how exRNA-based communication contributes to the initiation, progression, and persistence of medical problems caused by excessive and long-term alcohol consumption.
What kinds of alcohol-related health effects are relevant to this FOA?
The FOA discusses alcohol-related pathology across multiple organs and systems, including processes such as inflammation, tissue injury, immune dysregulation, metabolic changes, and other mechanisms that contribute to end-organ damage.
What kinds of scientific questions does NIH want applicants to address?
Examples of the kinds of questions highlighted by the FOA include: what exRNAs are released after alcohol exposure, where they originate, how they travel through circulation, which cells receive them, and what gene-regulatory effects they trigger in recipient cells.
Is this FOA limited to one organ system or disease area?
No. The FOA emphasizes cross-organ and cross-system communication and seeks insights that could change how alcohol-induced pathology is understood across diverse diseases rather than in isolated organ-specific silos.
Does the FOA include translational or clinical relevance?
Yes. A major expected payoff is translational, including the potential for exRNA signatures to serve as biomarkers and for specific exRNAs to point toward therapeutic strategies.
How could exRNA research supported by this FOA contribute to biomarker development?
The FOA notes that if certain exRNA signatures reliably track alcohol exposure, disease stage, or organ injury, they could be useful for diagnosis, risk stratification, monitoring disease progression, or measuring response to treatment.
How could exRNA research supported by this FOA contribute to therapeutics?
The FOA suggests that if specific exRNAs are shown to causally drive injury pathways, they could inform strategies such as blocking harmful vesicle signaling, modifying exRNA packaging and release, or targeting downstream pathways activated when cells take up exRNAs.
Does the FOA only focus on harmful effects of alcohol?
No. In addition to chronic heavy use and alcohol-related disease, the FOA explicitly allows research into the mechanistic basis of reported health effects sometimes associated with moderate alcohol consumption, using the same exRNA communication framework.
What is the award ceiling for this opportunity?
The listed award ceiling is $200,000.
Is cost-sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
What is the activity category for this grant?
The activity category is Health.
What CFDA number is associated with this opportunity?
The opportunity aligns with CFDA number 93.273 (Alcohol Research Programs).
When was this opportunity posted?
The opportunity was posted on April 15, 2013.
What were the closing dates for applications?
The original and final closing date listed is May 7, 2016.
Is this FOA still open for applications?
No. The opportunity has an archive date of June 7, 2016, indicating it is no longer open for new applications under that specific announcement.
If this FOA is archived, does that mean the topic is no longer fundable?
Not necessarily. The information provided notes that while this specific announcement is no longer open, similar topics may appear in newer NIH funding opportunities.
Who is eligible to apply?
Eligibility is broad and includes: public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations other than small businesses; small businesses; independent school districts; and various levels of government (city/township, county, state, and special district).
Are tribal entities eligible?
Yes. Tribal governments and tribal organizations are included in the eligibility categories.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible.
Are minority-serving institutions explicitly included?
Yes. The eligibility list includes categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly included among eligible applicants.
Can foreign (non-U.S.) organizations apply?
Yes. Foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by NIH policy are allowed.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site at the link provided in the source data.
Browse more opportunities from the same category: Health
Next opportunity: Development Innovation Ventures Annual Program Statement (APS)
Previous opportunity: BJA FY 13 Edward Byrne Memorial Justice Assistance Grant (JAG) Program FY 2013 State Solicitation
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 13 197
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 13 197) also looked into and applied for these:
| Funding Opportunity |
|---|
| Research Initiative for Scientific Enhancement (RISE) (R25) Apply for PAR 13 196 Funding Number: PAR 13 196 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCD Research On Hearing Health Care (R21/R33) Apply for RFA DC 14 001 Funding Number: RFA DC 14 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pediatric Suicide Prevention in Emergency Departments (U01) Apply for RFA MH 14 070 Funding Number: RFA MH 14 070 Agency: National Institutes of Health Category: Health Funding Amount: $2,400,000 |
| NIH Administrative Supplements to Recover Losses Due to Hurricane Sandy Under the Disaster Relief Appropriations Act Non Construction (Admin Supp) Apply for RFA OD 13 199 Funding Number: RFA OD 13 199 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition Restoration of New Investigator Pilot Projects Adversely Affected by Hurricane Sandy (R21) Apply for RFA OD 13 005 Funding Number: RFA OD 13 005 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Small Market Awards SBIR Phase IIB Competing Renewals for Heart, Lung, Blood and Sleep Technologies with Small Commercial Markets (R44) Apply for RFA HL 14 012 Funding Number: RFA HL 14 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Evidence Based Laboratory Medicine Laboratory Medicine Best Practices Systematic Review Recommendations Evaluation Apply for CDC RFA OE13 1303 Funding Number: CDC RFA OE13 1303 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $200,000 |
| Limited Competition Shared Instrumentation For Hurricane Sandy Disaster Relief (S10) Apply for RFA OD 13 006 Funding Number: RFA OD 13 006 Agency: National Institutes of Health Category: Health Funding Amount: $2,000,000 |
| Limited CompetitionRestoring Research Resources Lost Due to Hurricane Sandy (R24) Apply for RFA OD 13 008 Funding Number: RFA OD 13 008 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| The Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Research Network (U19) Apply for RFA HS 13 009 Funding Number: RFA HS 13 009 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $500,000 |
| Optogenetic Tools for the Study of Neural Systems in Aging and Alzheimers Disease (R01) Apply for RFA AG 14 002 Funding Number: RFA AG 14 002 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Pharmacological Approaches to Evaluating Drug Regimens to Address Antimicrobial Resistance (R01) Apply for RFA AI 13 024 Funding Number: RFA AI 13 024 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| AHRQ Patient Centered Outcomes Research (PCOR) Institutional Mentored Career Development Program (K12) Apply for RFA HS 13 008 Funding Number: RFA HS 13 008 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| Integrated Rural Program to Improve Nutrition and Hygiene in Mali APS Apply for APS 688 13 000001 Funding Number: APS 688 13 000001 Agency: Mali USAID Bamako Category: Health Funding Amount: $10,000,000 |
| Hazardous Materials Worker Health and Safety Training (U45) Administrative Supplements for Hurricane Sandy Response and Recovery (Admin Supp) Apply for RFA ES 13 008 Funding Number: RFA ES 13 008 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| FY 2013 Screening, Brief Intervention, and Referral to Treatment (SBIRT) Medical Professional Training Program Apply for TI 13 002 Funding Number: TI 13 002 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $314,661 |
| MARC Undergraduate Student Training in Academic Research (U STAR) National Research Service Award (NRSA) Institutional Research Training Grant (T34) Apply for PAR 13 205 Funding Number: PAR 13 205 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAMS Clinical Trial Outcome Instrument Development Grant Program (U01) Apply for RFA AR 14 008 Funding Number: RFA AR 14 008 Agency: National Institutes of Health Category: Health Funding Amount: $150,000 |
| Law Enforcement and Behavioral Health Partnerships for Early Diversion Apply for SM 13 005 Funding Number: SM 13 005 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $322,222 |
| Engaging State and Local Emergency Management Agencies to Improve Ability to Prepare for and Respond to All Hazards Events Apply for CDC RFA TP13 1301 Funding Number: CDC RFA TP13 1301 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $100,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 13 197", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.