Opportunity Information: Apply for PAS 06 466
Apply for PAS 06 466
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "The Role of Nuclear Receptors in Tissue and Organismal Aging (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.396 Cancer Biology Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 10, 2006.
- Applicants must submit their applications by Sep 7, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments State governments County governments Small businesses Public housing authorities/Indian housing authorities City or township governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments).
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Applicants may submit more than one application, provided each application is scientifically distinct.
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Opportunity Summary:
The NIH funding opportunity announcement PAS 06 466, titled "The Role of Nuclear Receptors in Tissue and Organismal Aging (R21)," supports early stage, exploratory research that looks at how nuclear receptors help shape the biology of aging and how those aging processes connect to disease and decline in midlife and older age. The scientific focus is on uncovering underlying mechanisms, especially the roles of nuclear receptors, their co-regulators, and related intracellular signaling pathways that influence aging at the tissue level and across the whole organism. In practical terms, the FOA is aimed at projects that can open up new directions, test new hypotheses, or generate preliminary mechanistic evidence about how nuclear receptor systems contribute to aging trajectories and age-associated pathophysiology.
This announcement uses the Exploratory/Developmental Research Grant mechanism (R21), which is generally intended for higher-risk, earlier proof-of-concept work compared with larger, more mature research programs. The R21 structure is meant to encourage innovative ideas and pilot-style studies where the science is promising but not yet fully established. The FOA also notes that it runs in parallel with a companion announcement, PAS 06 467, which has the same scientific scope but uses the R01 mechanism, a better fit for more developed projects with a stronger base of preliminary data and a longer, more comprehensive research plan.
Funding levels and the number of awards are not fixed and will depend on congressional appropriations, participating institute budgets, and how many strong applications are received that fall within the relevant funding lines. The estimated total funding listed for the FOA is $1,200,000, and the stated award ceiling is $200,000. Because projects can vary widely in approach, scope, and cost, the NIH indicates that both the size and duration of awards may vary, and that final decisions will reflect the number, quality, duration, and budget needs of the submitted proposals.
Multiple NIH institutes and centers are involved, reflecting the cross-cutting nature of nuclear receptor biology in aging and disease. The FOA specifically references participation and funding lines tied to the National Institute on Aging (NIA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Cancer Institute (NCI), and the National Institute of Environmental Health Sciences (NIEHS). The associated CFDA program areas listed in the source data include Aging Research (93.866), Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847), Cancer Biology Research (93.396), and Environmental Health (93.113), which signals that projects could be relevant to a range of age-linked conditions and biological contexts, including metabolic disease, cancer-related processes, and environmentally influenced mechanisms.
Eligibility is broad. A wide range of domestic applicants can apply, including public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and many units of government (state, county, city or township, special district governments, public housing authorities, and independent school districts). The FOA also allows applications from federally recognized tribal governments and other tribal organizations. Importantly, foreign institutions are eligible to apply, and eligible federal agencies can also submit applications. Applicants may submit more than one application as long as each submission is scientifically distinct, which is useful for research groups that want to pursue multiple mechanistic angles or different model systems without forcing everything into a single proposal.
From an administrative standpoint, this is a discretionary grant opportunity issued by the National Institutes of Health. It was posted July 10, 2006, with later record dates showing creation on December 5, 2008. The original closing date is listed as July 2, 2009, with a current closing date of September 7, 2009, and an archive date of October 7, 2009. The FOA indicates there is no cost sharing or matching requirement. For applicants needing the full text or experiencing access issues, the announcement points to the NIH Grants Guide page (linked in the listing) and provides NIH Office of Extramural Research webmaster contact information for technical difficulties.
Overall, the opportunity is designed to stimulate innovative, mechanistic research on how nuclear receptor networks and their regulatory partners influence aging biology and the development of age-associated disorders, using the R21 mechanism to enable exploratory studies that can establish new lines of evidence and set the stage for future, larger-scale work (including, for some projects, a potential later transition to an R01 pathway via the companion FOA).
Frequently Asked Questions (FAQs)
What is the funding opportunity and what is its official title?
The opportunity is an NIH Funding Opportunity Announcement (FOA) identified as PAS 06 466. Its title is "The Role of Nuclear Receptors in Tissue and Organismal Aging (R21)."
What is the main purpose of this FOA?
This FOA supports early-stage, exploratory research aimed at understanding how nuclear receptors shape the biology of aging and how aging processes connect to disease and functional decline in midlife and older age.
What kind of research does the FOA encourage?
It encourages projects that open new directions, test new hypotheses, or generate preliminary mechanistic evidence about how nuclear receptor systems contribute to aging trajectories and age-associated pathophysiology.
What scientific areas are emphasized in the announcement?
The scientific focus is on uncovering underlying mechanisms, particularly the roles of nuclear receptors, their co-regulators, and related intracellular signaling pathways that influence aging at the tissue level and across the whole organism.
What grant mechanism is used, and what does that imply about project maturity?
The announcement uses the Exploratory/Developmental Research Grant mechanism (R21). This mechanism is generally intended for higher-risk, earlier proof-of-concept work and pilot-style studies where the science is promising but not yet fully established compared with larger, more mature research programs.
Is there a companion announcement for more developed projects?
Yes. PAS 06 466 runs in parallel with a companion announcement, PAS 06 467, which has the same scientific scope but uses the R01 mechanism, which is better suited for more developed projects with stronger preliminary data and a longer, more comprehensive research plan.
How much funding is available in total under this FOA?
The estimated total funding listed for the FOA is $1,200,000. Actual funding depends on congressional appropriations, participating institute budgets, and the number of strong applications received within relevant funding lines.
Is there a maximum award amount (award ceiling)?
Yes. The stated award ceiling is $200,000.
Are the number of awards and award sizes fixed?
No. Funding levels and the number of awards are not fixed. NIH indicates that both the size and duration of awards may vary, and final decisions will reflect the number, quality, duration, and budget needs of submitted proposals.
Which NIH Institutes and Centers are involved?
The FOA references participation and funding lines tied to the National Institute on Aging (NIA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Cancer Institute (NCI), and the National Institute of Environmental Health Sciences (NIEHS).
What program areas (CFDA) are associated with this opportunity?
The associated CFDA program areas listed include Aging Research (93.866), Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847), Cancer Biology Research (93.396), and Environmental Health (93.113).
What does the cross-cutting institute participation suggest about project fit?
It signals that relevant projects may span multiple biological and disease contexts linked to aging, including areas such as metabolic disease, cancer-related processes, and environmentally influenced mechanisms, as long as the work aligns with the FOA's emphasis on nuclear receptor biology in aging.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and many units of government (such as state, county, city or township, special district governments, public housing authorities, and independent school districts). Federally recognized tribal governments and other tribal organizations are also eligible.
Are foreign institutions eligible to apply?
Yes. The FOA states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The FOA indicates that eligible federal agencies can submit applications.
Can an applicant submit more than one application?
Yes. Applicants may submit more than one application as long as each submission is scientifically distinct.
What type of grant is this from an administrative perspective?
This is a discretionary grant opportunity issued by the National Institutes of Health (NIH).
When was this FOA posted, and what key dates are listed?
The FOA was posted on July 10, 2006. Record dates also show creation on December 5, 2008. The original closing date is listed as July 2, 2009, with a current closing date of September 7, 2009, and an archive date of October 7, 2009.
Is cost sharing or matching required?
No. The FOA indicates there is no cost sharing or matching requirement.
Where can applicants find the full announcement text or get help if they have technical access issues?
The listing points applicants to the NIH Grants Guide page for the full text. For technical difficulties accessing materials, it provides NIH Office of Extramural Research webmaster contact information.
What is the overall goal of the program in practical terms?
The overall goal is to stimulate innovative, mechanistic research on how nuclear receptor networks and their regulatory partners influence aging biology and the development of age-associated disorders, using the R21 mechanism to enable exploratory studies that can establish new lines of evidence and potentially set the stage for later, larger-scale work (including possible transition to an R01 pathway via the companion FOA).
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Applicants also applied for:
Applicants who have applied for this opportunity (PAS 06 466) also looked into and applied for these:
| Funding Opportunity |
|---|
| Understanding and Promoting Health Literacy(R21) Apply for PAR 07 018 Funding Number: PAR 07 018 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Structural Biology of Membrane Proteins (R01) Apply for PA 07 253 Funding Number: PA 07 253 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Networks and Pathways Collaborative Research Projects (R01) Apply for PA 07 266 Funding Number: PA 07 266 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| The Role of Nuclear Receptors in Tissue and Organismal Aging (R01) Apply for PAS 07 267 Funding Number: PAS 07 267 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Global Research Initiative Program, Behavioral/Social Sciences (R01) Apply for PAR 07 328 Funding Number: PAR 07 328 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $50,000 |
| Innovations in Biomedical Computational Science and Technology (R01) Apply for PAR 07 344 Funding Number: PAR 07 344 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Psychopharmacology of Widely Available Psychoactive Natural Products (R01) Apply for PA 07 374 Funding Number: PA 07 374 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Psychopharmacology Of Widely Available Psychoactive Natural Products (R03) Apply for PA 07 375 Funding Number: PA 07 375 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Predictive Multiscale Models of the Physiome in Health and Disease (R01) Apply for PAR 08 023 Funding Number: PAR 08 023 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Nanoscience and Nanotechnology in Biology and Medicine (R01) Apply for PA 08 052 Funding Number: PA 08 052 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Nanoscience and Nanotechnology in Biology and Medicine (R21) Apply for PA 08 053 Funding Number: PA 08 053 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R21) Apply for PA 08 141 Funding Number: PA 08 141 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01) Apply for PA 08 140 Funding Number: PA 08 140 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Exploratory Collaborations with National Centers for Biomedical Computing (R21) Apply for PAR 08 183 Funding Number: PAR 08 183 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Collaborations with National Centers for Biomedical Computing (R01) Apply for PAR 08 184 Funding Number: PAR 08 184 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Metals in Medicine (R01) Apply for PA 08 251 Funding Number: PA 08 251 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Mechanism for Time Sensitive Research Opportunities (R21) Apply for PAR 07 345 Funding Number: PAR 07 345 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology Initiative (SBIR R43/R44) Apply for PAR 07 160 Funding Number: PAR 07 160 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42) Apply for PAR 07 161 Funding Number: PAR 07 161 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Global Research Initiative Program, Basic/Biomedical Sciences (R01) Apply for PAR 07 239 Funding Number: PAR 07 239 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
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