Opportunity Information: Apply for RFA DA 16 006
Apply for RFA DA 16 006
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Tools for Monitoring and Manipulating Modified RNAs in the Nervous System (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Jul 21, 2015 and posted on Jul 21, 2015.
- Applicants must submit their applications by Nov 18, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $150,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
The funding opportunity titled "Tools for Monitoring and Manipulating Modified RNAs in the Nervous System (R41/R42)" (Funding Opportunity Number RFA-DA-16-006) is a discretionary NIH grant program focused on stimulating small business innovation in the area of covalently modified eukaryotic RNA, with an emphasis on nervous system applications. In practical terms, it is aimed at helping small companies develop new research tools, enabling technologies, and product-ready platforms that allow scientists to detect, track, quantify, and experimentally manipulate chemical modifications on RNA molecules in neural tissues or nervous system models. These RNA modifications (often discussed in the context of "epitranscriptomics") can influence how RNAs are processed, localized, translated into protein, or degraded, and they are increasingly implicated in brain development, neural plasticity, and disease processes relevant to substance use and addiction.
This announcement uses the NIH Small Business Innovation Research mechanism, specifically the R41/R42 pathway. That structure supports a phased approach in which early-stage feasibility and proof-of-concept work (Phase I, typically associated with R41) can be followed by a more intensive development and validation stage (Phase II, typically associated with R42) if the initial milestones are met. The intent is to move ideas beyond basic academic discovery and toward robust, usable tools that the broader research community can adopt, whether those tools are kits, reagents, assays, engineered enzymes, imaging probes, sequencing-based workflows, computational pipelines tied to wet-lab methods, or other technologies that make it easier to measure and control modified RNAs in neurologically relevant contexts.
From an applicant and eligibility standpoint, the program is limited to small businesses. Non-U.S. (foreign) organizations are not eligible to apply as applicants, and non-U.S. components of U.S. organizations are also not eligible to apply. However, foreign components, as defined under NIH policy, may be allowable in some circumstances, which typically means a U.S.-based small business could potentially include certain foreign collaborations or activities if they are justified and compliant with NIH grants policy. The opportunity does not require cost sharing or matching funds, which is important for small businesses that may not have significant non-federal capital available during early product development.
Administratively, this opportunity was posted and created on July 21, 2015. The original and current closing date listed is November 18, 2015, and the archive date is December 19, 2015, indicating that the specific solicitation is no longer open. The estimated total funding amount listed is $150,000, which signals a relatively modest overall set-aside for awards under this specific announcement and reinforces that the program is meant to catalyze targeted tool-building efforts rather than fund large-scale, multi-year research programs.
The sponsoring agency is the National Institutes of Health, and it is associated with CFDA number 93.279, "Drug Abuse and Addiction Research Programs." That alignment suggests the scientific motivation includes building RNA-modification technologies that can be applied to questions tied to drug abuse, addiction neuroscience, and related neurological or psychiatric conditions. Even though the technological scope is broad, the program framing implies an expectation that applicants will make a clear case for nervous system relevance, such as compatibility with neurons, glia, brain tissue, neural circuits, or model systems commonly used in neurobiology and addiction research.
For those looking to locate the full archived solicitation details, NIH provided an official link in the grants guide (http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-16-006.html). NIH also provided support contacts through the NIH Office of Extramural Research webmaster for access or link troubleshooting (FBOWebmaster@OD.NIH.GOV), which is typical for NIH announcements where applicants may need help retrieving the full text or resolving technical access issues.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Tools for Monitoring and Manipulating Modified RNAs in the Nervous System (R41/R42)" and the Funding Opportunity Number is RFA-DA-16-006.
Which agency sponsors this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What is the main purpose of this funding opportunity?
This program is intended to stimulate small business innovation to create new research tools and enabling technologies for detecting, tracking, quantifying, and experimentally manipulating covalently modified eukaryotic RNA, with a particular emphasis on applications in the nervous system.
What scientific area does the program focus on?
The focus is on covalently modified eukaryotic RNA (often discussed under "epitranscriptomics") and developing practical toolsets for studying and controlling these RNA modifications in neural tissues or nervous system models.
Why are modified RNAs important in nervous system research?
According to the opportunity description, chemical modifications on RNA can influence RNA processing, localization, translation, and degradation, and they are increasingly implicated in brain development, neural plasticity, and disease processes relevant to substance use and addiction.
What types of projects or products are expected to be developed?
The announcement emphasizes tool-building efforts that can become robust and usable by the broader research community. Examples mentioned include kits, reagents, assays, engineered enzymes, imaging probes, sequencing-based workflows, and computational pipelines tied to wet-lab methods, as well as other technologies that make it easier to measure and control modified RNAs in neurologically relevant contexts.
What grant mechanism does this opportunity use?
This announcement uses the NIH Small Business Innovation Research (SBIR) mechanism, specifically the R41/R42 pathway.
How does the R41/R42 phased structure work in this announcement?
The program supports a phased approach: Phase I (typically associated with R41) supports early-stage feasibility and proof-of-concept work, and Phase II (typically associated with R42) supports more intensive development and validation if the Phase I milestones are met.
Who is eligible to apply?
The program is limited to small businesses.
Are non-U.S. (foreign) organizations eligible to apply as the applicant?
No. Non-U.S. (foreign) organizations are not eligible to apply as applicants.
Can a U.S. small business include non-U.S. components or activities?
Non-U.S. components of U.S. organizations are not eligible to apply. However, the announcement notes that foreign components (as defined under NIH policy) may be allowable in some circumstances, meaning a U.S.-based small business may be able to include certain foreign collaborations or activities if justified and compliant with NIH grants policy.
Is cost sharing or matching funding required?
No. The opportunity does not require cost sharing or matching funds.
When was this funding opportunity posted?
The opportunity was posted and created on July 21, 2015.
What was the application closing date?
The original and current closing date listed is November 18, 2015.
Is this solicitation still open?
No. The archive date is December 19, 2015, indicating the specific solicitation is no longer open.
What is the estimated total funding amount listed for this opportunity?
The estimated total funding amount listed is $150,000.
What does the listed total funding amount suggest about the scope of awards?
Based on the description provided, the relatively modest estimated total funding amount suggests the program is intended to catalyze targeted tool-building efforts rather than support large-scale, multi-year research programs.
How is this opportunity connected to drug abuse and addiction research?
The opportunity is associated with CFDA number 93.279, "Drug Abuse and Addiction Research Programs," indicating an expectation that proposed technologies will be relevant to nervous system questions tied to drug abuse, addiction neuroscience, and related neurological or psychiatric conditions.
What kind of nervous system relevance is implied for proposed tools?
The framing implies applicants should make a clear case that the tools are compatible with nervous system research contexts, such as neurons, glia, brain tissue, neural circuits, or model systems commonly used in neurobiology and addiction research.
Where can I find the full (archived) solicitation text?
NIH provided an official archived link in the grants guide: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-16-006.html
Who can I contact for help accessing the solicitation link or troubleshooting?
NIH provided the NIH Office of Extramural Research webmaster contact for access or link troubleshooting: FBOWebmaster@OD.NIH.GOV
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