Opportunity Information: Apply for RFA DA 16 005
Apply for RFA DA 16 005
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Tools for Monitoring and Manipulating Modified RNAs in the Nervous System (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Jul 21, 2015 and posted on Jul 21, 2015.
- Applicants must submit their applications by Nov 18, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
Tools for Monitoring and Manipulating Modified RNAs in the Nervous System (R43/R44) is a National Institutes of Health (NIH) small business grant opportunity designed to push the development of practical research tools and enabling technologies focused on covalently modified eukaryotic RNA, particularly in the context of the nervous system. The central aim is to incentivize small businesses to create products that make it easier to detect, measure, track, and experimentally manipulate RNA chemical modifications, which are increasingly recognized as important regulators of RNA fate and function. In plain terms, the opportunity targets tool-building rather than basic discovery alone, with an emphasis on platforms and methods that researchers can use to monitor modified RNAs and to perturb those modifications in biologically meaningful ways.
This funding announcement is identified as RFA-DA-16-005 and is offered as a discretionary grant under the NIH umbrella, with the funding activity aligned to health-related research (CFDA 93.279, Drug Abuse and Addiction Research Programs). The mechanism is the SBIR/STTR-style phased structure indicated by R43/R44, meaning it supports small businesses developing innovations from early feasibility work (Phase I, typically R43) through further development and potential commercialization steps (Phase II, typically R44). The program structure signals an expectation that applicants propose a clear development plan, demonstrate technical feasibility, and move toward a deployable tool, technology, or product that the broader research community can use.
Eligibility is limited to small businesses, and the announcement explicitly states that non-U.S. (foreign) entities are not eligible to apply. In addition, non-U.S. components of U.S. organizations are not eligible. However, foreign components may be allowed as defined in the NIH Grants Policy Statement, which generally means a U.S.-based applicant may, in some cases, include certain scientifically justified foreign elements as part of the project while still keeping the applicant organization itself domestic. There is no cost sharing or matching requirement, so applicants are not required to provide matching funds to be considered.
Key administrative dates included a posted and created date of July 21, 2015, with an original and current closing date of November 18, 2015, and an archive date of December 19, 2015. While those dates indicate the specific opportunity as listed is historical and archived, the summary remains useful as a model of the types of tool-development priorities NIH has supported in the modified RNA space, especially when tied to neuroscience-relevant questions and drug abuse/addiction research program interests.
For applicants or readers seeking the full official details, NIH provided an additional information link to the complete announcement on the NIH grants site (http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-16-005.html). For access issues or technical problems with the online listing, the contact route provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV, which is intended for troubleshooting access and linking problems rather than scientific program consultation.
Frequently Asked Questions (FAQs)
What is the "Tools for Monitoring and Manipulating Modified RNAs in the Nervous System (R43/R44)" opportunity?
This is a National Institutes of Health (NIH) small business grant opportunity focused on developing practical research tools and enabling technologies for studying covalently modified eukaryotic RNA, particularly in the nervous system.
What is the main goal of this funding announcement?
The central aim is to encourage small businesses to build products and platforms that make it easier to detect, measure, track, and experimentally manipulate RNA chemical modifications. The emphasis is on tool-building that researchers can use, not basic discovery alone.
What kinds of work does this program emphasize?
It emphasizes development of enabling technologies and platforms that allow researchers to monitor modified RNAs and perturb those modifications in biologically meaningful ways, especially in nervous system contexts.
Is this opportunity about basic research discoveries or about building tools?
Based on the description provided, the target is tool development rather than basic discovery alone. Projects are expected to move toward a usable tool, technology, or product.
What does "modified RNA" mean in this context?
The opportunity is focused on covalently modified eukaryotic RNA, meaning RNA that contains chemical modifications. These modifications are increasingly recognized as important regulators of RNA fate and function.
Why is the nervous system specifically mentioned?
The opportunity is framed around modified RNAs in the nervous system, signaling that proposed tools should be relevant to neuroscience contexts where tracking and manipulating RNA modifications can help answer biologically meaningful questions.
What is the funding announcement number?
The funding announcement is identified as RFA-DA-16-005.
Which agency is offering this grant?
This opportunity is offered under the NIH umbrella as a discretionary grant.
Is this related to drug abuse and addiction research programs?
Yes. The activity is aligned to health-related research under CFDA 93.279, which is listed as Drug Abuse and Addiction Research Programs.
What do R43 and R44 mean for applicants?
R43/R44 indicates an SBIR/STTR-style phased structure supporting small business innovation from early feasibility work (Phase I, typically R43) through further development and potential commercialization steps (Phase II, typically R44).
What is expected from applicants under the phased R43/R44 structure?
The structure signals an expectation that applicants propose a clear development plan, demonstrate technical feasibility, and progress toward a deployable tool, technology, or product that the broader research community can use.
Who is eligible to apply?
Eligibility is limited to small businesses.
Are non-U.S. (foreign) organizations eligible to apply?
No. The announcement explicitly states that non-U.S. (foreign) entities are not eligible to apply.
Can non-U.S. components of a U.S. organization participate?
No. The announcement states that non-U.S. components of U.S. organizations are not eligible.
Are any foreign components allowed at all?
Foreign components may be allowed as defined in the NIH Grants Policy Statement. In general terms, this can mean a U.S.-based applicant may be able to include certain scientifically justified foreign elements as part of the project while the applicant organization remains domestic.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, so applicants are not required to provide matching funds to be considered.
When was this opportunity posted?
The posted and created date listed is July 21, 2015.
What were the closing date and archive date?
The original and current closing date listed is November 18, 2015, and the archive date is December 19, 2015.
Is this funding opportunity still active?
Based on the dates provided (closing in 2015 and archived in 2015), the specific opportunity as listed is historical and archived.
Is the archived listing still useful for applicants today?
It can still be useful as a model of the types of tool-development priorities NIH has supported in the modified RNA space, especially when tied to neuroscience-relevant questions and drug abuse/addiction research program interests.
Where can I find the full official announcement text?
NIH provided a link to the complete announcement on the NIH grants site: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-16-005.html
Who should I contact if I have trouble accessing the online listing?
For access issues or technical problems with the online listing, the contact route provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Is the OER webmaster contact intended for scientific or program questions?
No. The provided contact is intended for troubleshooting access and linking problems rather than scientific program consultation.
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| Tools for Monitoring and Manipulating Modified RNAs in the Nervous System (R41/R42) Apply for RFA DA 16 006 Funding Number: RFA DA 16 006 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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| Avenir Award Program for Genetics or Epigenetics of Substance Abuse (DP1) Apply for RFA DA 16 007 Funding Number: RFA DA 16 007 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
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| NIDA Translational Avant Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3) Apply for RFA DA 16 008 Funding Number: RFA DA 16 008 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,000,000 |
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| Biosignatures of Chronic Drug Exposure (R21) Apply for RFA DA 09 022 Funding Number: RFA DA 09 022 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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| Small Grants Program for Cancer Epidemiology (R03) Apply for PAR 08 237 Funding Number: PAR 08 237 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Unique Interactions Between Tobacco Use and HIV/AIDS (R01) Apply for PA 08 253 Funding Number: PA 08 253 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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