Opportunity Information: Apply for PA 12 143
Apply for PA 12 143
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Toward an Improved Understanding of HDL Function (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Mar 28, 2012 and posted on Mar 28, 2012.
- Applicants must submit their applications by Sep 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments Independent school districts City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Toward an Improved Understanding of HDL Function (R01)" (Funding Opportunity Number PA-12-143) is a discretionary research grant designed to push the field beyond simply measuring HDL cholesterol levels and toward a clearer, more practical understanding of what HDL actually does in the body. The core focus is on HDL function: how HDL particles carry out protective activities that may influence cardiovascular disease risk, and how those activities can be measured reliably across studies and laboratories. The announcement emphasizes that progress in this area depends on better tools and shared standards, so it specifically encourages projects that develop, validate, and standardize laboratory and translational assays that can quantify HDL functional properties and identify biomarkers that reflect those functions.
A central theme of the opportunity is improving how researchers measure multiple HDL functional activities that are thought to matter in cardiovascular biology. The FOA highlights innovative approaches to assessing in vivo reverse cholesterol transport (RCT), which is the process by which cholesterol is moved out of peripheral tissues (including artery wall macrophages) and ultimately handled by the liver for excretion. In addition to RCT, the announcement calls out HDL-related anti-oxidant, anti-inflammatory, and anti-thrombotic activities as important functional domains where improved measurement methods are needed. In practice, this means applicants are encouraged to propose new assays, refine existing ones, and demonstrate that these assays are accurate, reproducible, and suitable for broader adoption. Just as importantly, the opportunity is interested in biomarkers for HDL function, meaning measurable biological indicators (molecular, cellular, or biochemical) that can serve as proxies for functional HDL behavior in research and, potentially, in clinical settings.
The FOA also encourages discovery-oriented work aimed at identifying new pathways and potential HDL targets connected to HDL function. This includes exploring novel functional mechanisms of HDL particles, the proteins and lipids that give HDL its diverse activities, and the molecular pathways through which HDL interacts with immune cells, endothelial cells, platelets, and other relevant tissues. The announcement makes clear that the intent is not only to create better readouts of HDL function, but also to uncover previously unrecognized biology that might explain why HDL behaves differently across individuals, disease states, and therapeutic interventions. Projects that connect these mechanistic findings to therapeutic ideas are explicitly welcomed, including research that explores HDL-related pathways as drug targets, or evaluates interventions intended to improve HDL function rather than simply raising HDL-C levels.
From an administrative standpoint, this is an R01 mechanism, meaning it supports substantial, hypothesis-driven research projects that can include method development, validation studies, and mechanistic investigations, as long as they align with the program goals around HDL functional assays, biomarkers, and pathways. The program is categorized under Health, with a CFDA listing of 93.837 (Cardiovascular Diseases Research). There is no cost sharing or matching requirement, which lowers barriers for many applicants and aligns with standard NIH research grant practices.
Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants span state and local governments, federally recognized and other tribal entities, public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3) in certain cases), small businesses, and other for-profit organizations (other than small businesses). The announcement also explicitly includes institutions and organizations serving specific populations, such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities, as well as faith-based and community-based organizations where appropriate. Importantly, foreign institutions are eligible to apply, foreign components are allowed, and non-U.S. components of U.S. organizations may participate, consistent with NIH policy on foreign involvement.
Key dates for this specific posting show it was originally posted and created on March 28, 2012, with an original and current closing date of September 7, 2012, and an archive date of October 8, 2012. While those dates indicate the specific announcement has been archived, the scientific priorities it reflects remain useful as a guide to what NIH sought to advance in HDL research at that time: standardized and meaningful measures of HDL function, credible biomarkers tied to function, and deeper biological insight that could point toward new therapeutic strategies.
For applicants or readers seeking the official text and full requirements, the opportunity provided an NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PA-12-143.html). For technical issues accessing the announcement, the listed contact was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name and funding opportunity number of this NIH grant?
The opportunity is titled "Toward an Improved Understanding of HDL Function (R01)" and the Funding Opportunity Number is PA-12-143.
What type of grant mechanism is used?
This opportunity uses the NIH R01 mechanism, which supports substantial, hypothesis-driven research projects. The description indicates projects may include method development, validation studies, and mechanistic investigations when aligned with the FOA goals.
What is the main scientific purpose of this FOA?
The FOA is intended to move the field beyond simply measuring HDL cholesterol levels and toward a clearer, more practical understanding of HDL function: what HDL does in the body, how those activities may influence cardiovascular disease risk, and how to measure those activities reliably across studies and laboratories.
What does the FOA mean by focusing on "HDL function" rather than HDL-C?
Instead of focusing on how much HDL cholesterol (HDL-C) is present, the FOA emphasizes measuring what HDL particles actually do biologically, including protective activities relevant to cardiovascular biology, and establishing measurements that are accurate and reproducible across labs.
What kinds of projects are specifically encouraged?
The FOA specifically encourages projects that develop, validate, and standardize laboratory and translational assays that can quantify HDL functional properties. It also encourages efforts to identify biomarkers that reflect HDL functions.
Why does the FOA emphasize shared standards and better tools?
The announcement states that progress depends on better tools and shared standards, and it highlights a need for measurement approaches that are reliable and comparable across different studies and laboratories.
Which HDL functional activities are highlighted as priorities for improved measurement?
The FOA highlights the need to improve measurement of multiple HDL functional activities, including innovative approaches to assessing in vivo reverse cholesterol transport (RCT), as well as HDL-related anti-oxidant, anti-inflammatory, and anti-thrombotic activities.
What is reverse cholesterol transport (RCT) in the context of this FOA?
RCT is described as the process by which cholesterol is moved out of peripheral tissues (including artery wall macrophages) and ultimately handled by the liver for excretion. The FOA calls for innovative approaches to assessing this process in vivo.
Does the FOA allow applicants to propose new assays as well as refine existing ones?
Yes. The FOA encourages applicants to propose new assays, refine existing assays, and demonstrate that the assays are accurate, reproducible, and suitable for broader adoption.
What does the FOA require or emphasize about assay performance?
It emphasizes demonstrating that assays are accurate and reproducible and that they are suitable for broader adoption, with an overall aim of improving reliability and comparability across studies and laboratories.
What does the FOA mean by "biomarkers for HDL function"?
Biomarkers for HDL function are described as measurable biological indicators (molecular, cellular, or biochemical) that can serve as proxies for functional HDL behavior in research and potentially in clinical settings.
Is discovery-oriented research in scope, or is it limited to assay development?
Discovery-oriented work is explicitly encouraged. The FOA supports identifying new pathways and potential HDL targets connected to HDL function, including exploring novel functional mechanisms of HDL particles.
What types of mechanistic topics does the FOA mention?
The FOA mentions studying the proteins and lipids that give HDL diverse activities and the molecular pathways through which HDL interacts with immune cells, endothelial cells, platelets, and other relevant tissues.
Does the FOA support connecting HDL function findings to therapeutic ideas?
Yes. Projects that connect mechanistic findings to therapeutic ideas are explicitly welcomed, including research that explores HDL-related pathways as drug targets or evaluates interventions intended to improve HDL function rather than simply raising HDL-C levels.
What is the program area or category for this opportunity?
The program is categorized under Health, with a CFDA listing of 93.837 (Cardiovascular Diseases Research).
Is there any cost sharing or matching requirement?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes a wide range of domestic and international organizations, including state and local governments, federally recognized and other tribal entities, public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) in certain cases), small businesses, and other for-profit organizations (other than small businesses).
Are institutions serving specific populations included in eligibility?
Yes. The announcement explicitly includes institutions and organizations such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities, as well as faith-based and community-based organizations where appropriate.
Are foreign institutions eligible? Are foreign components allowed?
Yes. Foreign institutions are eligible to apply, foreign components are allowed, and non-U.S. components of U.S. organizations may participate, consistent with NIH policy on foreign involvement.
What were the key dates for this specific posting?
The FOA was originally posted and created on March 28, 2012. The original and current closing date is listed as September 7, 2012, and the archive date is October 8, 2012.
Is this specific FOA still active?
The listed dates indicate the specific announcement has been archived (archive date: October 8, 2012).
Where can someone find the official FOA text and full requirements?
The FOA provided an NIH Grants Guide link: http://grants.nih.gov/grants/guide/pa-files/PA-12-143.html
Who was the listed contact for technical issues accessing the announcement?
For technical issues accessing the announcement, the listed contact was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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