Translational Research at the Aging/Cancer Interface (TRACI) (R21) | Apply Online

Opportunity Summary:

The Translational Research at the Aging/Cancer Interface (TRACI) (R21) funding opportunity (PA-08-231) is a National Institutes of Health (NIH) grant announcement led by the National Institute on Aging (NIA) focused on translational research that sits at the intersection of human aging and cancer. The central aim is to support projects that intentionally connect basic laboratory discoveries with clinical realities for older adults, using both "bench-to-bedside" approaches (moving mechanistic insights toward patient-oriented applications) and "bedside-to-bench" approaches (using clinical observations and patient needs to drive new basic research questions). The expectation is that supported work will ultimately contribute to better health and quality of life for older people who are at risk for cancer or living with a cancer diagnosis, with particular emphasis on reducing functional decline, morbidity, and the broader burdens cancer places on aging individuals.

This announcement uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is designed for early-stage, innovative, or high-impact exploratory studies where preliminary data may be limited and the work may be more developmental in nature. In practical terms, the R21 format is often used to test novel concepts, generate proof-of-concept data, establish feasibility of new translational strategies, or develop tools and approaches that can later be scaled into larger projects. The TRACI R21 runs alongside a companion opportunity of the same scientific scope that uses the R01 mechanism (PA-08-230), giving applicants a choice between a smaller, exploratory award (R21) and a more traditional full research project grant (R01), depending on the maturity and scale of the proposed work.

Funding levels and the number of awards are not fixed in advance because the program anticipates a wide range of possible translational projects, each with different timelines, complexity, and resource needs. That said, the listed award ceiling is $200,000 (as presented in the source data), and NIH notes that the final number and size of awards will depend on the quantity, quality, duration, and cost of applications received. There is no cost sharing or matching requirement, which means applicants are not expected to provide institutional matching funds as a condition of the award.

Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, with exclusions noted for institutions of higher education in those categories), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). The eligibility list also explicitly includes a wide range of mission- and community-focused entities and historically underrepresented institutions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal governments and tribal organizations (with distinctions between federally recognized and other tribal entities), faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations and non-domestic entities. Federal agencies are also included as eligible applicants per the eligibility notes.

From an administrative standpoint, this is a discretionary grant opportunity in the health funding category under CFDA 93.866 (Aging Research). The opportunity was posted on August 8, 2008, later recorded with a creation date of September 15, 2011, and it lists an original closing date of September 7, 2011, with a current closing date of January 7, 2012, and an archive date of February 7, 2012. The full announcement and official details were provided through the NIH grants website (linked in the opportunity), and applicants who had trouble accessing the electronic materials were directed to contact the NIH Office of Extramural Research (OER) webmaster via the email addresses included in the notice.

In short, TRACI (R21) is aimed at catalyzing creative, translational aging-and-cancer research that directly informs the prevention, diagnosis, treatment, and supportive care of cancer in older adults, with a clear emphasis on outcomes that matter in aging such as function, independence, and reducing the real-world complications and long-term impacts of cancer and its treatment in elderly populations.

Browse more opportunities from the same agency: National Institutes of Health

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Next opportunity: NINDS Exploratory/Developmental Projects in Translational Research (R21)

Previous opportunity: Translational Research at the Aging/Cancer Interface (TRACI) (R01)

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