Opportunity Information: Apply for PAR 09 156
Apply for PAR 09 156
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Translational Research in Pediatric and Obstetric Pharmacology (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Apr 10, 2009 and posted on Apr 10, 2009.
- Applicants must submit their applications by May 19, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Small businesses Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments Independent school districts For profit organizations other than small businesses County governments Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Translational Research in Pediatric and Obstetric Pharmacology (R21) opportunity (Funding Opportunity Number PAR-09-156) is an NIH grant announcement from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) aimed at advancing how medicines are developed, evaluated, and used in children and in pregnant women. The central idea is to support translational research that can meaningfully improve drug safety and effectiveness for these populations, which are often underserved by traditional drug development and clinical testing approaches. Projects under this FOA are expected to focus on practical, scientifically grounded steps that move discoveries toward better therapeutic use in real-world pediatric and obstetric care.
The FOA highlights three main scientific goals. First, it encourages pharmacologic studies that address how drug actions and responses differ across childhood developmental stages, how pediatric responses differ from adult responses, and how pregnancy changes drug behavior compared with non-pregnant physiology. This includes the recognition that maturation, growth, organ development, and pregnancy-related physiologic changes can substantially alter pharmacokinetics and pharmacodynamics, making it unsafe to assume that adult dosing, metabolism, or side effect profiles translate directly to infants, children, adolescents, or pregnant patients. Second, the announcement supports the development of new drugs or new therapeutic strategies specifically intended for children and pregnant women, reflecting a push to move beyond simply adapting adult medications. Third, it explicitly promotes multidisciplinary collaboration, particularly partnerships between basic scientists and physician-scientists, to strengthen the pipeline from mechanistic insights to clinically relevant interventions in obstetrics and pediatrics.
In terms of funding structure, this FOA uses the NIH Exploratory/Developmental Research Grant mechanism (R21). The R21 mechanism is generally intended for early-stage, exploratory, or proof-of-concept studies that may involve higher risk but also the potential for high impact, often laying groundwork for larger subsequent projects. This R21 FOA runs in parallel with two companion announcements that share the same scientific scope but use different mechanisms: PAR-09-155 for the R01 (traditional research project grant) and PAR-09-154 for the R03 (small grant). Applicants are expected to choose the mechanism that best fits their project scope, maturity, and resource needs.
The financial details provided indicate an award ceiling of $275,000, and there is no cost-sharing or matching requirement. The announcement notes that the actual size, duration, and number of awards will vary depending on the range and quality of applications received, as well as their budgets and timelines. In other words, NICHD did not commit to a fixed number of awards; funding outcomes depend on scientific merit and available funds.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profit entities), and a wide range of government bodies such as state, county, city/township governments, special district governments, public housing authorities/Indian housing authorities, and independent school districts. The eligibility list also explicitly includes tribal governments (federally recognized and other than federally recognized) and tribal organizations. In addition, the FOA identifies other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, foreign (non-U.S.) entities, and eligible federal agencies. This breadth signals an intent to attract diverse research teams and settings, including those with direct access to relevant patient populations and clinical networks.
Administratively, the opportunity falls under the NIH and is categorized as a discretionary grant within the broad area of health. The CFDA listing included is 93.865 (Child Health and Human Development Extramural Research). Key dates included a posted/creation date of April 10, 2009, with a closing date of May 19, 2011, and an archive date of June 19, 2011, indicating the announcement is historical rather than currently open. For full details, the FOA referenced the NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PAR-09-156.html) and provided NIH Office of Extramural Research (OER) webmaster contact information for access or linking issues.
Overall, PAR-09-156 is designed to push forward translational pharmacology focused on the unique therapeutic needs of children and pregnant women, emphasizing developmental and pregnancy-related differences in drug response, the creation or refinement of therapies for these groups, and team-based approaches that connect laboratory science with clinical care.
Frequently Asked Questions (FAQs)
What is PAR-09-156?
PAR-09-156 is an NIH funding opportunity titled "Translational Research in Pediatric and Obstetric Pharmacology (R21)." It is sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and focuses on improving how medicines are developed, evaluated, and used in children and in pregnant women through translational research.
Which NIH Institute is sponsoring this opportunity?
The sponsoring NIH Institute is the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What is the main purpose of this FOA?
The FOA aims to support translational research that can meaningfully improve drug safety and effectiveness for children and pregnant women. It emphasizes practical, scientifically grounded steps that move discoveries toward better therapeutic use in real-world pediatric and obstetric care.
What research areas does the FOA emphasize?
The FOA highlights three main scientific goals: (1) pharmacologic studies of developmental and pregnancy-related differences in drug actions and responses, (2) development of new drugs or new therapeutic strategies intended for children and pregnant women, and (3) multidisciplinary collaboration, especially partnerships between basic scientists and physician-scientists, to strengthen translation to clinically relevant interventions.
What kinds of pharmacology questions are encouraged under this FOA?
The FOA encourages studies that address how drug actions and responses differ across childhood developmental stages, how pediatric responses differ from adult responses, and how pregnancy changes drug behavior compared with non-pregnant physiology. It recognizes that maturation, growth, organ development, and pregnancy-related physiologic changes can alter pharmacokinetics and pharmacodynamics.
Why does the FOA focus on children and pregnant women?
The FOA notes that these populations are often underserved by traditional drug development and clinical testing approaches, and it emphasizes that it can be unsafe to assume adult dosing, metabolism, or side effect profiles translate directly to infants, children, adolescents, or pregnant patients.
What grant mechanism is used for PAR-09-156?
PAR-09-156 uses the NIH Exploratory/Developmental Research Grant mechanism (R21).
What does the R21 mechanism generally support?
The R21 mechanism is generally intended for early-stage, exploratory, or proof-of-concept studies. These projects may involve higher risk but have the potential for high impact and often lay the groundwork for larger subsequent projects.
Are there companion funding opportunities related to this FOA?
Yes. This R21 FOA runs in parallel with two companion announcements with the same scientific scope but different mechanisms: PAR-09-155 (R01) and PAR-09-154 (R03).
How should applicants choose between the R21, R01, and R03 companion announcements?
Applicants are expected to choose the mechanism that best fits their project scope, maturity, and resource needs. PAR-09-156 is specifically the R21 option for exploratory/developmental work.
What is the award ceiling for this opportunity?
The financial details provided indicate an award ceiling of $275,000.
Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
How many awards will NICHD make under this FOA?
The FOA does not commit to a fixed number of awards. It states that the actual size, duration, and number of awards will vary depending on the range and quality of applications received, as well as their budgets, timelines, and available funds.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (including small businesses), and many government bodies (state, county, city/township, special district, public housing authorities/Indian housing authorities, and independent school districts). It also includes tribal governments (federally recognized and other than federally recognized) and tribal organizations.
Are minority-serving institutions included as eligible applicants?
Yes. The FOA explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The eligibility list explicitly includes faith-based or community-based organizations.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA explicitly includes foreign (non-U.S.) entities among eligible applicants.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA includes U.S. territories or possessions as eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA includes eligible federal agencies as eligible applicants.
What federal program listing (CFDA) is associated with this opportunity?
The CFDA listing included is 93.865, described as Child Health and Human Development Extramural Research.
What is the broad funding category and area for this opportunity?
Administratively, it is under NIH and categorized as a discretionary grant within the broad area of health.
When was this FOA posted, and what were the key dates?
The FOA shows a posted/creation date of April 10, 2009. It lists a closing date of May 19, 2011, and an archive date of June 19, 2011.
Is PAR-09-156 currently open for applications?
No. Based on the listed closing date (May 19, 2011) and archive date (June 19, 2011), the announcement is historical rather than currently open.
Where can someone find the original FOA details?
The FOA references the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PAR-09-156.html for full details.
Who is listed for help with access or linking issues?
The FOA provides NIH Office of Extramural Research (OER) webmaster contact information for access or linking issues.
What does "translational research" mean in the context of this FOA?
In this FOA, translational research is framed as work that moves mechanistic or scientific discoveries toward better therapeutic use in real-world pediatric and obstetric care, with an emphasis on practical steps that improve drug safety and effectiveness for children and pregnant women.
Does the FOA encourage collaborative or team-based research?
Yes. The FOA explicitly promotes multidisciplinary collaboration, particularly partnerships between basic scientists and physician-scientists, to strengthen the path from mechanistic insights to clinically relevant interventions.
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Previous opportunity: Translational Research in Pediatric and Obstetric Pharmacology (R01)
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