Opportunity Information: Apply for PAS 10 252
Apply for PAS 10 252
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Treatment of Co Occurring Alcohol Use Disorders and Depression/Anxiety Disorders (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 19, 2010 and posted on Aug 5, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This funding opportunity (PAS 10 252) is a National Institutes of Health grant announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) focused on improving treatment for people who have both an alcohol use disorder and either depression or an anxiety disorder. For the purposes of this announcement, anxiety disorders explicitly include generalized anxiety disorder, social phobia (social anxiety disorder), and posttraumatic stress disorder. The overall goal is to support research that can lead to better clinical strategies for a population where psychiatric symptoms and alcohol problems commonly reinforce each other, complicate recovery, and increase relapse risk and impairment.
The scientific scope is intentionally broad, but it centers on treatment development and early testing. NIAAA is interested in innovative pharmacological approaches (for example, medication strategies that target neurobiological mechanisms relevant to both alcohol use and mood/anxiety symptoms), behavioral interventions (such as psychotherapies or integrated care models), and other treatment approaches grounded in biological, psychological, behavioral, and social/cultural models of how these co-occurring conditions develop and persist. The emphasis on multiple models signals that applicants can justify interventions from neurocircuitry and stress-response frameworks all the way to learning theory, behavioral economics, and culturally informed or context-specific approaches, as long as the work is clearly tied to improving outcomes for individuals with this comorbidity.
In addition to new or adapted interventions, the announcement also welcomes Comparative and Effectiveness Research in this specific comorbid population. That means applicants may propose studies that compare two or more existing treatments to determine which works better, for whom, and under what conditions, rather than inventing an entirely new treatment. This is particularly relevant in real-world clinical settings where providers must choose among established options, and where evidence from single-disorder trials may not translate well to people with both alcohol use disorder and depression/anxiety.
The mechanism is the NIH Exploratory/Developmental Research Grant (R21), which is designed for early-stage, high-potential projects that may involve piloting new ideas, collecting preliminary data, or testing feasibility and signals of efficacy before a larger definitive trial. This R21 announcement runs in parallel with a companion opportunity of the same scientific scope that uses the R01 mechanism (PAS 10 251), which is typically more appropriate for larger, more mature projects with stronger preliminary evidence and more extensive aims.
Funding levels and award expectations were described in terms of a set-aside and an anticipated number of awards for the fiscal year noted in the announcement. NIAAA indicated a set-aside of $1.5 million in total costs for FY 2011 and anticipated making up to six total awards across this announcement and its companion FOAs, depending on how many high-quality applications are received and on the proposed budgets and project durations. The award ceiling listed for this opportunity is $200,000. Like many NIH announcements, actual awards are contingent on the availability of funds and the submission of meritorious applications, so the final number and size of awards could vary.
Eligibility is broad and includes many organization types that commonly apply for NIH funding. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (with the non-501(c)(3) category excluding institutions of higher education), small businesses, and for-profit organizations other than small businesses. Governmental and community-based entities are also included, such as state governments, federally recognized Native American tribal governments, and tribal organizations. The eligibility notes further clarify that a wide range of additional entities may apply, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations and eligible federal agencies.
Administratively, this opportunity was posted in August 2010, with an original closing date in September 2013 and an archive date in October 2013, reflecting that it is no longer open for new submissions. The listing identifies the program area under CFDA 93.273 (Alcohol Research Programs) and notes there is no cost sharing or matching requirement. For applicants or readers who needed the full archived announcement, the opportunity provided an NIH grants guide link and general NIH Office of Extramural Research webmaster contacts for access or technical issues.
Frequently Asked Questions (FAQs)
What is PAS 10 252?
PAS 10 252 is an archived National Institutes of Health (NIH) funding opportunity announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It focuses on research to improve treatment for people who have both an alcohol use disorder (AUD) and either depression or an anxiety disorder.
Which NIH institute is sponsoring this opportunity?
The opportunity is sponsored by NIAAA (the National Institute on Alcohol Abuse and Alcoholism), an institute within the NIH.
What population is this grant focused on?
The scientific focus is on individuals who have co-occurring alcohol use disorder and either depression or an anxiety disorder, where symptoms can reinforce each other, complicate recovery, and increase relapse risk and impairment.
Which anxiety disorders are included under this announcement?
For the purposes of this announcement, anxiety disorders explicitly include generalized anxiety disorder, social phobia (social anxiety disorder), and posttraumatic stress disorder (PTSD).
What is the overall goal of the research supported by this FOA?
The overall goal is to support research that can lead to better clinical strategies for treating co-occurring AUD and depression/anxiety, with an emphasis on treatment development and early testing.
Is the scientific scope narrow or broad?
The scientific scope is intentionally broad, as long as the proposed work is clearly tied to improving outcomes for people with co-occurring AUD and depression or anxiety disorders.
What kinds of interventions does NIAAA want to support?
NIAAA is interested in innovative pharmacological approaches, behavioral interventions (including psychotherapies and integrated care models), and other treatment approaches grounded in biological, psychological, behavioral, and social/cultural models of these co-occurring conditions.
Does the opportunity support medication-based approaches?
Yes. The announcement highlights interest in innovative pharmacological approaches, including medication strategies that target neurobiological mechanisms relevant to both alcohol use and mood/anxiety symptoms.
Does the opportunity support behavioral or psychotherapy-based approaches?
Yes. The announcement explicitly includes behavioral interventions such as psychotherapies and integrated care models.
Do proposals have to be based on a specific scientific model (for example, neurobiology)?
No. The announcement signals that applicants may justify interventions using multiple models, ranging from neurocircuitry and stress-response frameworks to learning theory, behavioral economics, and culturally informed or context-specific approaches, as long as the work remains focused on improving outcomes for the comorbid population.
Are culturally informed or context-specific approaches allowed?
Yes. The scope explicitly allows approaches grounded in social/cultural models and context-specific frameworks, provided the work is clearly tied to improving clinical outcomes for individuals with the targeted comorbidity.
Does the announcement allow Comparative and Effectiveness Research?
Yes. In addition to new or adapted interventions, the announcement welcomes Comparative and Effectiveness Research in this specific comorbid population, including studies comparing two or more existing treatments to determine what works better, for whom, and under what conditions.
Do applicants have to invent a new treatment to apply?
No. The FOA also supports studies that compare existing treatments (Comparative and Effectiveness Research) in the comorbid AUD plus depression/anxiety population.
What grant mechanism is used for PAS 10 252?
This opportunity uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is intended for early-stage, high-potential projects such as piloting new ideas, collecting preliminary data, testing feasibility, and assessing signals of efficacy before a larger trial.
Is there a companion funding opportunity with a different mechanism?
Yes. This R21 FOA runs in parallel with a companion opportunity of the same scientific scope using the R01 mechanism (PAS 10 251), which is typically better suited to larger, more mature projects with stronger preliminary evidence and more extensive aims.
What funding amount did NIAAA set aside for the fiscal year referenced?
NIAAA indicated a set-aside of $1.5 million in total costs for FY 2011 across this announcement and its companion FOAs.
How many awards were anticipated?
NIAAA anticipated making up to six total awards across this announcement and its companion FOAs for the fiscal year noted, depending on the number of high-quality applications received and the proposed budgets and project durations.
What is the award ceiling listed for this opportunity?
The award ceiling listed for this opportunity is $200,000.
Are awards guaranteed at the set-aside level or maximum amount?
No. As with many NIH announcements, actual awards depend on the availability of funds and the receipt of meritorious applications. The final number and size of awards could vary.
Is cost sharing or matching required?
No. The listing states that there is no cost sharing or matching requirement.
What is the CFDA program number associated with this opportunity?
The listing identifies the program area under CFDA 93.273 (Alcohol Research Programs).
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (with the non-501(c)(3) category excluding institutions of higher education), small businesses, and for-profit organizations other than small businesses.
Are government entities eligible to apply?
Yes. Eligibility includes governmental entities such as state governments, federally recognized Native American tribal governments, and tribal organizations.
Are tribal entities and tribal colleges eligible?
Yes. The eligibility notes include federally recognized Native American tribal governments, tribal organizations, and tribally controlled colleges and universities (TCCUs).
Are minority-serving institutions eligible to apply?
Yes. The eligibility notes explicitly mention Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, and Alaska Native and Native Hawaiian serving institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed among the types of entities that may apply.
Are U.S. territories or possessions included in eligibility?
Yes. U.S. territories or possessions are included among eligible entities.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility notes indicate that non-U.S. (foreign) organizations may apply.
Are eligible federal agencies allowed to apply?
Yes. The eligibility notes indicate that eligible federal agencies may apply.
Is this funding opportunity still open?
No. The announcement is archived and is no longer open for new submissions.
When was this opportunity posted and when did it close?
It was posted in August 2010. The original closing date was in September 2013, and the archive date was in October 2013.
Where could applicants find the full archived announcement?
The opportunity referenced an NIH grants guide link for the full archived announcement.
Who is listed for help with access or technical issues?
The opportunity notes general NIH Office of Extramural Research webmaster contacts for access or technical issues.
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