Tropical Medicine Research Centers (U19) | Apply Online

Opportunity Summary:

The Tropical Medicine Research Centers (U19) funding opportunity (RFA-AI-16-002) is a National Institutes of Health (NIH) cooperative agreement program administered under HHS/NIH (listed as HHS-NIH11) that aims to support applied, field-relevant research on tropical diseases where they are actually endemic. The core purpose is to fund institutions and organizations that can carry out research focused on the causes of disease, improved diagnosis, prevention strategies, and treatment approaches for tropical diseases in real-world endemic settings. A central theme of the announcement is practicality and relevance to affected regions: the work is expected to be grounded in places where these diseases occur and where the public health need is highest, rather than being primarily laboratory- or clinic-based within the United States.

The scientific scope is intentionally narrow in one important way and broad in another. It is limited to select Neglected Tropical Diseases (NTDs) and the vectors that transmit them, meaning applicants must align their proposals with the eligible NTD targets and vector systems specified by the program. Within that boundary, however, the FOA encourages ambitious and integrated research approaches. Projects can focus on a single pathogen or cover multiple pathogens responsible for NTDs, and the program explicitly welcomes multi-disciplinary research. In practice, this means an application could combine, for example, epidemiology, entomology, clinical research, diagnostics development, implementation science, and intervention evaluation, as long as the work remains centered on the eligible NTDs and their vectors and is conducted in endemic environments.

Because this is a U19 cooperative agreement, it is designed for center-like, coordinated research efforts rather than isolated, single-project grants. Cooperative agreements typically imply substantial involvement from the funding agency in areas such as oversight, coordination, or collaboration expectations, and they often suit programs where NIH anticipates an active partnership to help the research network meet shared objectives. The intent here is to support organized research centers or center-style collaborations capable of sustained work in endemic regions, including the infrastructure and partnerships needed to execute studies responsibly and effectively in-country.

The FOA also draws a firm line around what it will not support: it is not meant for research that can be conducted primarily in U.S. institutions. That language signals that proposals should not simply use endemic countries as sample sources while most work occurs in U.S. laboratories. Instead, the center concept is geared toward research that is embedded in endemic areas, which generally implies local collaborations, on-the-ground study operations, and a focus on problems that are difficult or impossible to address without sustained presence in affected communities.

From an administrative perspective, the opportunity was posted on December 11, 2015 (creation and posted date both listed as December 11, 2015) with an application closing date of June 3, 2016 (both original and current closing dates match). The funding instrument type is a cooperative agreement, and the activity category is health. The CFDA numbers associated with this opportunity are 93.855 and 93.856, which correspond to NIH infectious disease and related research assistance programs. The listed award ceiling is $500,000, indicating the maximum award amount per the announcement record. The eligible applicant category is summarized as "Others (see text field entitled Additional Information on Eligibility for clarification)," which suggests eligibility was broader or more nuanced than a single standard category and would have required applicants to consult the full FOA text for specifics.

Overall, this opportunity is best understood as NIH support for collaborative tropical medicine research centers focused on select NTDs and their vectors, emphasizing multi-pathogen and multi-disciplinary approaches and prioritizing research that is conducted in endemic regions to directly advance understanding, diagnostics, prevention, and treatment where the burden is greatest.

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Previous opportunity: NIDCD Early Career Research (ECR) Award (R21)

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