Opportunity Information: Apply for RFA DK 10 012

  • The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Type I Diabetes Impact Award (DP3)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
  • This funding opportunity was created on Sep 16, 2010 and posted on Sep 16, 2010.
  • Applicants must submit their applications by Mar 11, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $30,000,000.00 to eligible and selected applicants.
  • Eligible applicants include: Native American tribal governments (Federally recognized) State governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Small businesses City or township governments Public housing authorities/Indian housing authorities Special district governments County governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Type I Diabetes Impact Award (DP3), Funding Opportunity Number RFA-DK-10-012, was a discretionary NIH grant program issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It was designed to support bold, high-impact research projects in Type 1 diabetes that go after fundamental unanswered questions or major barriers holding the field back. The core idea of this opportunity was to encourage applications that are genuinely original and potentially transformative, including studies that deliberately challenge existing assumptions or commonly accepted models in Type 1 diabetes research. Proposals were expected to be centered on a clearly defined, compelling question that, if answered, would meaningfully shift scientific understanding or open new paths toward prevention, treatment, or cure.

This award used the NIH Research Project Grant mechanism DP3, which in practice signaled an emphasis on “impact” and novelty rather than incremental advances. The activity category listed for the opportunity was Health (also tagged under Food and Nutrition/Health in the listing), and it fell under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). There was no cost sharing or matching requirement, meaning applicants were not required to commit non-federal funds as a condition of the award. The opportunity listed an estimated total funding amount of $30,000,000, indicating that NIDDK intended a substantial investment across the cohort of funded projects.

In terms of who could apply, the eligibility scope was broad and included a wide range of U.S.-based and non-U.S. organizations. Eligible applicants included federal, state, county, city/township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations both with and without 501(c)(3) status (including those other than universities); independent school districts; public housing authorities and Indian housing authorities; for-profit organizations other than small businesses; small businesses; Native American tribal governments (federally recognized) and tribal organizations (including those not federally recognized); and additional categories called out in the eligibility information. The additional eligible applicant types explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, non-domestic (non-U.S.) entities/foreign organizations, and U.S. territories or possessions. This wide eligibility framework was meant to maximize the chance that unconventional ideas and capable teams, wherever they were based, could compete.

From an applicant’s perspective, the most important “fit” requirement was conceptual: the proposed research needed to be groundbreaking and directly relevant to Type 1 diabetes, tackling a major obstacle or foundational gap in knowledge. The announcement emphasized that projects should not merely extend existing work in small steps; instead, they should aim for outsized scientific payoff, including lines of investigation that test or overturn prevailing dogma when justified by strong reasoning and a feasible plan. In other words, the program was trying to buy down the risk of daring ideas in exchange for the possibility of big leaps forward.

Key dates show that this was a time-limited solicitation. It was posted and created on September 16, 2010, with an original and current closing date of March 11, 2011, and it was archived on April 11, 2011. The sponsoring agency was the National Institutes of Health, with NIDDK as the issuing institute for this specific FOA. For reference and full administrative and scientific details, the announcement pointed to the NIH Grants Guide link at http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-10-012.html, and it listed NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues (FBOWebmaster@OD.NIH.GOV).

Frequently Asked Questions (FAQs): Type I Diabetes Impact Award (DP3) - RFA-DK-10-012

What is the Type I Diabetes Impact Award (DP3)?

The Type I Diabetes Impact Award (DP3) was a discretionary NIH grant opportunity issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It was designed to support bold, high-impact research projects in Type 1 diabetes that pursue fundamental unanswered questions or address major barriers holding the field back.

What was the Funding Opportunity Number (FOA) for this program?

The Funding Opportunity Number was RFA-DK-10-012.

Which agency sponsored and issued this funding opportunity?

The sponsoring agency was the National Institutes of Health (NIH), and the issuing institute for this specific opportunity was NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases).

What grant mechanism did this opportunity use?

This opportunity used the NIH Research Project Grant mechanism DP3. In practice, the DP3 mechanism signaled an emphasis on impact and novelty rather than incremental advances.

What kinds of research projects was NIDDK trying to fund through this DP3 opportunity?

The program sought genuinely original and potentially transformative Type 1 diabetes research. The focus was on projects aimed at fundamental unanswered questions or major barriers in the field, including studies that intentionally challenge existing assumptions or commonly accepted models when justified by strong reasoning and a feasible plan.

What was the most important "fit" requirement for applicants?

The main fit requirement was conceptual: proposals needed to be groundbreaking and directly relevant to Type 1 diabetes, tackling a major obstacle or foundational gap in knowledge. The solicitation emphasized that projects should not simply extend existing work in small steps, but should aim for outsized scientific payoff that could meaningfully shift understanding or open new paths toward prevention, treatment, or cure.

Did the program encourage higher-risk ideas?

Yes. The announcement emphasized supporting daring ideas in exchange for the possibility of major leaps forward. It specifically welcomed applications that challenge prevailing dogma or accepted models in Type 1 diabetes research, provided the rationale is strong and the plan is feasible.

What topic area or activity category was associated with this opportunity?

The activity category listed for the opportunity was Health (also tagged under Food and Nutrition/Health in the listing).

What CFDA number was associated with this funding opportunity?

The opportunity fell under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).

Was cost sharing or matching required?

No. There was no cost sharing or matching requirement, meaning applicants were not required to commit non-federal funds as a condition of receiving an award.

How much total funding was estimated for this program?

The opportunity listed an estimated total funding amount of $30,000,000, indicating that NIDDK intended a substantial investment across the cohort of funded projects.

Who was eligible to apply?

Eligibility was broad and included many U.S.-based and non-U.S. organizations. Eligible applicants included federal, state, county, city/township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with and without 501(c)(3) status (including those other than universities); independent school districts; public housing authorities and Indian housing authorities; for-profit organizations other than small businesses; small businesses; Native American tribal governments (federally recognized) and tribal organizations (including those not federally recognized); and additional categories specified in the eligibility information.

Were non-U.S. (foreign) organizations eligible to apply?

Yes. The eligibility information explicitly included non-domestic (non-U.S.) entities/foreign organizations.

Were U.S. territories or possessions eligible to apply?

Yes. U.S. territories or possessions were explicitly listed among the additional eligible applicant types.

Were small businesses eligible to apply?

Yes. Small businesses were included in the eligibility list.

Were for-profit organizations eligible to apply?

Yes. For-profit organizations other than small businesses were included in the eligibility list.

Were nonprofit organizations required to have 501(c)(3) status to be eligible?

No. The eligibility list included nonprofit organizations both with and without 501(c)(3) status.

Were colleges, universities, and other higher education institutions eligible?

Yes. Public and state-controlled institutions of higher education, as well as private institutions of higher education, were eligible.

Were minority-serving institutions specifically included in eligibility?

Yes. The additional eligible applicant types explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).

Were tribal governments and tribal organizations eligible?

Yes. The eligibility list included Native American tribal governments (federally recognized) and tribal organizations, including those not federally recognized.

Were faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations were explicitly included among the additional eligible applicant types.

Were regional organizations eligible to apply?

Yes. Regional organizations were listed among the additional eligible applicant types.

Were government entities eligible to apply?

Yes. Eligible government applicants included federal, state, county, city/township, and special district governments. The additional eligibility categories also included eligible federal agencies.

Were independent school districts eligible?

Yes. Independent school districts were included in the eligibility list.

Were public housing authorities eligible to apply?

Yes. Public housing authorities and Indian housing authorities were included as eligible applicants.

What were the key dates for this funding opportunity?

The opportunity was posted and created on September 16, 2010. The original closing date and current closing date were both March 11, 2011. It was archived on April 11, 2011.

Is this funding opportunity still open?

No. The closing date was March 11, 2011, and the opportunity was archived on April 11, 2011.

Where can applicants find the full official announcement details?

The announcement pointed to the NIH Grants Guide link: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-10-012.html

Who was listed for help with access or linking issues?

The opportunity listed NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues: FBOWebmaster@OD.NIH.GOV

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