Opportunity Information: Apply for PA 14 198
Apply for PA 14 198
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 8, 2014 and posted on May 1, 2014.
- Applicants must submit their applications by Dec 9, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The funding opportunity titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R01)" (Funding Opportunity Number PA 14-198) is a National Institutes of Health (NIH) discretionary grant program in the health area (CFDA 93.273, Alcohol Research Programs). It uses the NIH R01 mechanism, meaning it is intended to support substantial, hypothesis-driven research projects that can generate strong, publishable findings and open up new directions for the field. Cost sharing or matching is not required, which keeps the focus on scientific merit rather than institutional financial contributions.
The core purpose of the announcement is to stimulate integrated and innovative research that looks beyond the "classic" view of how the body processes alcohol. Rather than limiting attention to well-known metabolic steps, the FOA emphasizes novel and unconventional contributions of ethanol-metabolizing pathways, including the enzymes involved, the metabolites produced, and the cofactors that enable or regulate these reactions. A key theme is interaction: the NIH is explicitly interested in how ethanol metabolism connects with other biological pathways that may synergize with alcohol exposure to drive disease. In practical terms, this encourages applicants to explore cross-talk between alcohol metabolism and mechanisms such as oxidative stress, inflammation, mitochondrial dysfunction, lipid metabolism, epigenetic regulation, immune signaling, tissue repair, and other cellular systems that may amplify injury over time.
The public health problem the FOA targets is the broad range of alcohol-induced diseases and end-organ injuries that arise from excessive, long-term alcohol consumption. The agency is signaling that it wants studies capable of clarifying the cellular and molecular components that contribute to the initiation, progression, and maintenance of these disorders. That framing points to research that can identify early triggers, determine why damage worsens or becomes chronic, and explain why some individuals or tissues are more vulnerable than others. While the announcement does not list specific organs in the excerpt provided, "end organ injuries" commonly include conditions affecting the liver, pancreas, heart, brain, immune system, and other organ systems impacted by chronic alcohol exposure, and the language here is broad enough to accommodate diverse disease models and mechanistic angles.
A central expectation is that the funded work will produce data that could lead to breakthroughs in understanding alcohol-related pathology. The FOA highlights discovery of "key cellular and molecular components," which implies an interest in pinpointing actionable mechanisms rather than only descriptive findings. The longer-term payoff described is translational: improved knowledge that could eventually support better diagnosis, treatment, and clinical management of patient populations burdened by alcohol-induced conditions. The ultimate aim is better disease outcomes and, by extension, improvements in public health, suggesting that proposals that clearly connect mechanistic discoveries to potential biomarkers, therapeutic targets, or risk stratification strategies would fit the spirit of the program.
Eligibility is intentionally broad, spanning many organization types. Eligible applicants include public and private institutions of higher education, public/state-controlled institutions, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses, though not limited to them), and multiple levels of government (state, county, city/township, special district, independent school districts, and public housing authorities/Indian housing authorities). The eligibility language also explicitly includes a wide range of mission- and community-focused organizations and institutions, such as faith-based or community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and other minority-serving institutions including Alaska Native and Native Hawaiian-serving institutions and AANAPISI institutions. In addition, the FOA allows participation by U.S. territories or possessions, regional organizations, certain federal entities, and non-U.S. entities (foreign organizations), making it possible for international or cross-border collaborations to apply where consistent with NIH policy.
From an administrative standpoint, the opportunity was posted May 1, 2014, with a creation date of December 8, 2014. The original closing date was January 7, 2015, though the current closing date listed is December 9, 2014, and the archive date is January 8, 2015. As an archived NIH FOA, it serves primarily as a record of the program call and its priorities at that time, though similar scientific priorities may appear in newer NIH announcements. The official announcement page was hosted on the NIH grants site at the provided link, and NIH Office of Extramural Research (OER) webmaster contacts were provided for technical access or linking issues.
Overall, this R01 FOA is designed to push alcohol research toward deeper mechanistic insight into ethanol metabolism as a driver of disease, especially where enzymes, metabolites, and cofactors play unexpected roles or intersect with other biological systems. It encourages research that is both creative and integrated, with the explicit goal of uncovering mechanisms that could later support better clinical tools and interventions for alcohol-induced disorders.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA 14-198.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What CFDA program is associated with this opportunity?
The CFDA number listed is 93.273, Alcohol Research Programs.
What type of grant mechanism does this opportunity use?
It uses the NIH R01 mechanism, which is intended to support substantial, hypothesis-driven research projects.
What kind of research does an NIH R01 typically support in the context of this FOA?
The FOA frames the R01 as support for integrated, hypothesis-driven projects that can generate strong, publishable findings and open new directions for the field.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
What is the main purpose of this FOA?
The purpose is to stimulate integrated and innovative research that looks beyond the classic view of alcohol processing by investigating novel and unconventional contributions of ethanol-metabolizing pathways, including enzymes, metabolites, and cofactors.
What does the FOA mean by "unconventional roles" in ethanol metabolism?
Based on the description provided, "unconventional roles" refers to research that goes beyond the well-known metabolic steps and instead examines unexpected functions and impacts of ethanol-metabolizing enzymes, the metabolites produced, and the cofactors that enable or regulate these reactions.
What scientific theme is emphasized across the FOA?
A key theme is interaction, specifically how ethanol metabolism connects with other biological pathways that may synergize with alcohol exposure to drive disease.
What kinds of biological pathways or processes are highlighted as relevant to cross-talk with ethanol metabolism?
The FOA encourages exploring connections to mechanisms such as oxidative stress, inflammation, mitochondrial dysfunction, lipid metabolism, epigenetic regulation, immune signaling, tissue repair, and other cellular systems that may amplify injury over time.
What public health problem is this FOA targeting?
It targets the broad range of alcohol-induced diseases and end-organ injuries that arise from excessive, long-term alcohol consumption.
What types of outcomes is NIH looking for from funded projects?
The FOA emphasizes generating data that could lead to breakthroughs in understanding alcohol-related pathology, including identifying key cellular and molecular components involved in the initiation, progression, and maintenance of alcohol-induced disorders.
Does the FOA focus on early disease triggers or later-stage disease progression?
It is framed broadly to include clarifying early triggers, understanding why damage worsens or becomes chronic, and explaining differential vulnerability across individuals or tissues.
Are specific organs or disease models required?
The excerpt provided does not list specific organs. It uses broad language (end-organ injuries) that is described as accommodating diverse disease models and mechanistic angles.
How does this FOA describe the longer-term impact of the research?
The longer-term payoff is described as translational: improved knowledge that could eventually support better diagnosis, treatment, and clinical management of patient populations affected by alcohol-induced conditions, with the ultimate aim of improving public health.
Does the FOA suggest projects should connect mechanistic findings to clinical applications?
Yes in spirit. The description indicates that proposals connecting mechanistic discoveries to potential biomarkers, therapeutic targets, or risk stratification strategies would fit the intent of the program.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, public/state-controlled institutions, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government (state, county, city/township, special district, independent school districts, and public housing authorities/Indian housing authorities).
Are community-based and faith-based organizations eligible?
Yes. The eligibility language explicitly includes faith-based and community-based organizations.
Are minority-serving institutions explicitly included?
Yes. The eligibility description explicitly includes HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and other minority-serving institutions, including Alaska Native and Native Hawaiian-serving institutions and AANAPISI institutions.
Can non-U.S. organizations apply?
Yes. The eligibility language includes non-U.S. entities (foreign organizations), and it also allows participation by U.S. territories or possessions and regional organizations, consistent with NIH policy.
Is this funding opportunity still open?
No. It is described as an archived NIH FOA.
When was the opportunity posted and when did it close?
It was posted May 1, 2014. The original closing date was January 7, 2015. The listing also notes a current closing date of December 9, 2014, and an archive date of January 8, 2015.
Why are there multiple dates listed (original closing date, current closing date, archive date)?
The provided information lists an original closing date (January 7, 2015), a current closing date (December 9, 2014), and an archive date (January 8, 2015). The excerpt does not explain the discrepancy, but it does clearly indicate the FOA is archived.
Where was the official announcement hosted?
The official announcement page was hosted on the NIH grants site (at the provided link in the source description).
Who was listed as a contact for technical or website issues?
NIH Office of Extramural Research (OER) webmaster contacts were provided for technical access or linking issues.
What is the main takeaway for applicants reviewing this archived FOA?
The FOA reflects NIH priorities at the time it was active: pushing alcohol research toward deeper mechanistic insight into ethanol metabolism, especially where enzymes, metabolites, and cofactors play unexpected roles or intersect with other biological systems, with an eye toward eventual clinical relevance.
Browse more opportunities from the same category: Health
Next opportunity: Bureau of Democracy, Human Rights and Labor Request for Proposals Democracy, Human Rights, and Religious Freedom in Nigeria.
Previous opportunity: National Park Service Upland Processes and Controls on Sept 2013 Mass Movements
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 14 198
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 14 198) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIAMS Clinical Trial Implementation Cooperative Agreement (U01) Apply for PAR 14 200 Funding Number: PAR 14 200 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAMS Clinical Trial Planning Cooperative Agreement (U34) Apply for PAR 14 199 Funding Number: PAR 14 199 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Sudden Death in the Young (SDY) Registry Apply for CDC RFA DP14 1403 Funding Number: CDC RFA DP14 1403 Agency: NCCDPHP Category: Health Funding Amount: $200,000 |
| NEI Administrative Supplements to Small Business Innovative Research (SBIR) Grants for the Procurement of Expertise in the Federal Regulatory Approval Process for New Drugs and/or Devices (Admin Supp) Apply for PA 14 205 Funding Number: PA 14 205 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Strengthening a network of immunization programs to support the NCIRD mission to prevent disease through immunization Apply for CDC RFA IP14 1402 Funding Number: CDC RFA IP14 1402 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $700,000 |
| Enhancing Cancer Registries for Early Case Capture (ECC) of Pediatric and Young Adult Cancer (PYAC) Cases Apply for CDC RFA DP14 1402 Funding Number: CDC RFA DP14 1402 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Enhancing Cancer Genomic Best Practices through Education, Surveillance, and Policy Apply for CDC RFA DP14 1407 Funding Number: CDC RFA DP14 1407 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $350,000 |
| HIV Vaccine Research and Design (HIVRAD) Program (P01) Apply for PAR 14 206 Funding Number: PAR 14 206 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Protecting and Improving Public Health Globally Building and Strengthening Public Health Impact, Systems, Capacity and Security Apply for CDC RFA GH14 1418 Funding Number: CDC RFA GH14 1418 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01) Apply for PAR 14 207 Funding Number: PAR 14 207 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Longitudinal Assessment of Post traumatic Syndromes (U01) Apply for RFA MH 15 110 Funding Number: RFA MH 15 110 Agency: National Institutes of Health Category: Health Funding Amount: $5,000,000 |
| Enhancing situational awareness, surveillance, detection, risk assessment and response activities using a mapping and visualization tool Apply for CDC RFA CK14 1404 Funding Number: CDC RFA CK14 1404 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,000,000 |
| NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre Clinical Research (R44) Apply for PAR 14 209 Funding Number: PAR 14 209 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Exploratory Clinical Trials and Clinical Research (R44) Apply for PAR 14 208 Funding Number: PAR 14 208 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Affordable Care Act SHIP and ADRC Options Counseling for Medicare Medicaid Individuals in States with Approved Financial Alignment Models Apply for CMS 1N1 14 001 Funding Number: CMS 1N1 14 001 Agency: Centers for Medicare Medicaid Services Category: Health Funding Amount: $1,000,000 |
| Pharmacogenomics Knowledge Base (R24) Apply for RFA GM 15 002 Funding Number: RFA GM 15 002 Agency: National Institutes of Health Category: Health Funding Amount: $1,600,000 |
| Local Nongovernmental Partnerships for Sustained Country Leadership in Rwanda under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH14 1414 Funding Number: CDC RFA GH14 1414 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| FY14 Minority Youth Violence Prevention Integrating Public Health and Community Policing Approaches Apply for MP YEP 14 001 Funding Number: MP YEP 14 001 Agency: Office of the Assistant Secretary for Health Category: Health Funding Amount: $400,000 |
| NIMHD Social, Behavioral, Health Services, and Policy Research on Minority Health and Health Disparities (R01) Apply for RFA MD 14 004 Funding Number: RFA MD 14 004 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| NIMHD Basic and Applied Biomedical Research on Minority Health and Health Disparities (R01) Apply for RFA MD 14 005 Funding Number: RFA MD 14 005 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 14 198", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.