Opportunity Information: Apply for PA 12 234
Apply for PA 12 234
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 8, 2014 and posted on Jul 10, 2012.
- Applicants must submit their applications by Dec 9, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) State governments County governments Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Independent school districts City or township governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R21)" (Funding Opportunity Number PA-12-234) is an NIH discretionary grant solicitation aimed at supporting early stage, innovative research that explores how alcohol (ethanol) metabolism contributes to disease in ways that go beyond the traditional or well-established mechanisms. The central focus is on ethanol-metabolizing pathways and the less commonly studied roles of the enzymes involved, the metabolic byproducts they generate, the cofactors required for these reactions, and how these elements interact with other biological pathways that may amplify or modify alcohol-related harm. In practical terms, the FOA is looking for research that connects biochemical and molecular events in ethanol metabolism to downstream cellular dysfunction and organ injury, especially where the mechanisms are novel, unconventional, or previously underappreciated.
A key scientific goal of the FOA is to encourage integrated approaches that can reveal new cellular and molecular components driving the initiation, progression, and persistence of alcohol-induced disorders. Rather than funding incremental work, this R21 mechanism is positioned to help investigators generate exploratory or proof-of-concept data that could open new lines of investigation. The expectation is that these studies will produce insights capable of reshaping how the field understands alcohol-related pathology, including the possibility of identifying previously unknown targets for intervention. The broader public health rationale is that long-term heavy alcohol use is linked to a wide range of medical problems and end-organ injuries, and improved mechanistic understanding can eventually translate into better diagnosis, treatment strategies, and clinical management for patient populations who are particularly vulnerable to alcohol-induced disease.
From an administrative standpoint, this is a grant (Funding Instrument Type: Grant) within the health research category, associated with CFDA number 93.273 (Alcohol Research Programs). The FOA does not require cost sharing or matching funds, which can reduce barriers for applicants who may not have access to institutional or third-party matching resources. The award ceiling listed is $200,000, reflecting the typical scale of an R21-style exploratory project budget cap (generally intended to support limited-scope, high-impact exploratory studies rather than large multi-year programs).
Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, for-profit organizations (other than small businesses), and multiple levels of government (state, county, city/township, special district governments, independent school districts, and certain housing authorities). The FOA explicitly includes tribal entities and tribal-serving institutions, such as Federally recognized Native American tribal governments, tribal organizations not federally recognized, and Tribally Controlled Colleges and Universities. It also recognizes a variety of mission-focused institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy, signaling that the NIH is open to internationally situated expertise where it advances the scientific aims.
Key dates in the source listing indicate the opportunity was posted on July 10, 2012, with administrative record dates showing creation on December 8, 2014, and closing windows around late 2014 to early 2015 (with a current closing date of December 9, 2014, an original closing date of January 7, 2015, and an archive date of January 8, 2015). The administering agency is the National Institutes of Health. For applicants or readers needing the full announcement text, the FOA provides an NIH guide link (http://grants.nih.gov/grants/guide/pa-files/PA-12-234.html) and directs technical access issues to the NIH Office of Extramural Research (OER) webmaster contacts.
Overall, this FOA is designed to seed creative, cross-cutting research that reframes ethanol metabolism as more than a linear detoxification process, emphasizing instead that ethanol-metabolizing enzymes, their metabolites, and required cofactors may have broader biological effects that interact with other pathways to drive complex disease outcomes. The intended long-term payoff is a stronger mechanistic foundation that can support future breakthroughs in clinical detection and therapeutic strategies for the wide spectrum of alcohol-induced pathologies, ultimately improving patient outcomes and advancing public health.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R21)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-12-234.
Which agency is administering this grant opportunity?
The administering agency is the National Institutes of Health (NIH).
What type of funding instrument is this?
This opportunity uses a Grant funding instrument.
What does the R21 mechanism imply for the type of projects being sought?
Based on the description provided, the R21 mechanism is intended to support early-stage, innovative, exploratory, or proof-of-concept research rather than incremental work or large, long-term programs. The emphasis is on generating insights and initial data that could open new research directions.
What scientific topic area does this opportunity focus on?
The central focus is ethanol (alcohol) metabolism and how ethanol-metabolizing pathways contribute to health and disease, particularly through roles that are novel, unconventional, or previously underappreciated.
What is meant by "unconventional roles" of ethanol-metabolizing enzymes, metabolites, and cofactors?
In this FOA, "unconventional roles" refers to functions and impacts beyond the traditional or well-established mechanisms of ethanol metabolism. This includes less commonly studied roles of ethanol-metabolizing enzymes, the metabolic byproducts (metabolites) they generate, the cofactors required for these reactions, and how these elements interact with other biological pathways that may amplify or modify alcohol-related harm.
What kinds of research approaches does the FOA encourage?
The FOA encourages integrated approaches that connect biochemical and molecular events in ethanol metabolism to downstream cellular dysfunction and organ injury, especially where the mechanisms are new, cross-cutting, or not widely recognized in the existing literature.
What kinds of outcomes or impacts are expected from projects funded under this FOA?
The stated expectation is that funded studies will produce insights that could reshape how the field understands alcohol-related pathology, potentially including identification of previously unknown targets for intervention and a stronger mechanistic basis for improved diagnosis, treatment strategies, and clinical management.
What health or public health problem is this FOA trying to address?
The public health rationale described is that long-term heavy alcohol use is linked to a wide range of medical problems and end-organ injuries, and better mechanistic understanding of alcohol-induced disease can support future advances in patient care and public health.
Is this opportunity limited to traditional mechanisms of alcohol-related harm?
No. The opportunity explicitly aims to go beyond traditional or well-established mechanisms by supporting research into less commonly studied enzymes, metabolites, cofactors, and pathway interactions connected to ethanol metabolism.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The listing indicates that cost sharing or matching funds are not required.
What is the maximum award amount (award ceiling) stated in the listing?
The award ceiling listed is $200,000.
Who is eligible to apply?
Eligibility is described as broad and includes domestic and international organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations (other than small businesses), and multiple levels of government (including state, county, city/township, special district governments, independent school districts, and certain housing authorities).
Are tribal entities and tribal-serving institutions eligible?
Yes. The FOA explicitly includes Federally recognized Native American tribal governments, tribal organizations not federally recognized, and Tribally Controlled Colleges and Universities.
Are specific institution types like HBCUs and Hispanic-serving Institutions eligible?
Yes. The eligibility description recognizes mission-focused institutions including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Can foreign (non-U.S.) institutions apply?
Yes. The information provided states that non-U.S. entities (foreign institutions) are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The listing states that non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed under NIH policy?
Yes. The information provided notes that foreign components are allowed as defined by NIH policy.
When was this opportunity posted?
The source listing indicates the opportunity was posted on July 10, 2012.
What dates are given for creation and closing/archiving in the listing?
The administrative record dates shown include a creation date of December 8, 2014, closing windows around late 2014 to early 2015 (including a current closing date of December 9, 2014, an original closing date of January 7, 2015), and an archive date of January 8, 2015.
Where can applicants find the full announcement text?
The FOA provides an NIH guide link to the full announcement text: http://grants.nih.gov/grants/guide/pa-files/PA-12-234.html
Where should technical access issues be directed?
The FOA directs technical access issues to the NIH Office of Extramural Research (OER) webmaster contacts.
Does this FOA focus on specific organs or disease endpoints?
The description emphasizes downstream cellular dysfunction and organ injury broadly, with an overall aim of understanding alcohol-induced disorders, but it does not list specific organs or named disease endpoints in the information provided.
Is the goal to fund incremental research or more exploratory work?
The FOA is positioned to support exploratory and innovative work and explicitly notes it is not intended to fund incremental research.
What is the broader scientific theme of the FOA?
The broader theme is reframing ethanol metabolism as more than a linear detoxification process by examining how ethanol-metabolizing enzymes, their metabolites, and required cofactors may have wider biological effects and interact with other pathways to drive complex disease outcomes.
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