Opportunity Information: Apply for PAS 08 048
Apply for PAS 08 048
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Understanding and Preventing Brain Tumor Dispersal (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 17, 2007.
- Applicants must submit their applications by Jan 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education For profit organizations other than small businesses County governments State governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Native American tribal governments (Federally recognized) Special district governments Public housing authorities/Indian housing authorities.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH funding opportunity titled "Understanding and Preventing Brain Tumor Dispersal (R01)" (Funding Opportunity Number PAS 08 048) supports research aimed at explaining why and how brain tumor cells spread through the brain, and how that knowledge can be turned into strategies that stop or reduce invasion. A major problem in malignant brain tumors is not only the growth of the primary mass, but the ability of tumor cells to migrate into surrounding normal brain tissue, making surgical removal and localized therapies far less effective. This announcement is designed to push the field toward a clearer, mechanistic understanding of dispersal and toward practical interventions that can specifically target the invasive cells that escape the main tumor.
The scientific goals are organized around three connected themes. First, the program seeks studies that identify the intrinsic properties of brain tumor cells that drive migration, meaning the cell-level features that make certain tumor cells especially capable of moving through brain tissue. This could include molecular pathways, cytoskeletal dynamics, adhesion properties, protease activity, metabolic adaptations, or other traits that enable motility in the unique brain environment. Second, the FOA emphasizes the role of the normal brain microenvironment in shaping tumor movement. That includes how tumor cells interact with normal brain elements such as neurons, glia (including astrocytes and oligodendrocytes), microglia/macrophages, endothelial cells and blood vessels, extracellular matrix components, and structural routes like white matter tracts. The underlying idea is that invasion is not only a tumor-cell program, but also a behavior influenced by the surrounding tissue. Third, the announcement explicitly encourages translation of these insights into interventions, meaning approaches that use what is learned about migration and microenvironmental interactions to design therapies or strategies that prevent, limit, or redirect dispersal, with a focus on targeting invading tumor cells rather than only shrinking the primary tumor core.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is generally intended for mature, hypothesis-driven projects with a well-developed research plan. It runs in parallel with a companion announcement (PAS 08 049) that uses the R21 Exploratory/Developmental mechanism and has the same scientific scope, offering a pathway for earlier-stage or higher-risk concept testing while this R01 supports more fully developed studies. The funding activity falls within health and research areas connected to cancer and neuroscience, reflected in the CFDA listings 93.393 (Cancer Cause and Prevention Research) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
In terms of funding, the National Institute of Neurological Disorders and Stroke (NINDS) set aside a combined total of $400,000 per year in total costs for this R01 announcement and the parallel R21 announcement. These set-aside funds are described as being in addition to funds available for applications that score within the standard NINDS payline, and awards ultimately depend on scientific merit, relevance, and funds availability over the life of the announcement. The National Cancer Institute (NCI) is also involved in funding decisions and indicates it will consider both programmatic priority and scientific merit. Because projects can vary widely in scope, model systems, and experimental approach, the announcement notes that award size, duration, total dollars, and number of awards are not fixed and will depend on the number of applications received, their quality, requested budgets, and project periods.
Eligibility is broad and includes many types of domestic organizations such as public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and various government entities (state, county, city/township, special districts, independent school districts, and public housing authorities/Indian housing authorities). The eligibility language also states that foreign institutions may apply, eligible federal agencies may apply, and faith-based or community-based organizations may apply. In addition, Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments) are listed among eligible applicants, along with other organizations as clarified in the full announcement.
Key administrative details place the opportunity historically in the 2007-2011 window: the opportunity was posted on December 17, 2007, with an original and current closing date of January 7, 2011, and an archive date of February 7, 2011. The sponsoring agency is the National Institutes of Health, and the full text of the announcement was made available through the NIH Grants Guide at the listed link. For access or technical issues related to the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): Understanding and Preventing Brain Tumor Dispersal (R01) - PAS 08 048
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Understanding and Preventing Brain Tumor Dispersal (R01)" and the Funding Opportunity Number is PAS 08 048.
What problem is this funding opportunity trying to address?
This program focuses on a major challenge in malignant brain tumors: tumor cells do not only grow as a primary mass, but also migrate into surrounding normal brain tissue. This dispersal makes surgical removal and localized therapies far less effective because invasive cells can escape beyond the main tumor core.
What is the overall purpose of the research supported by this FOA?
The FOA supports research aimed at explaining why and how brain tumor cells spread through the brain, and how that knowledge can be turned into strategies that stop or reduce invasion, with an emphasis on practical interventions that specifically target invasive cells.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Research Project Grant (R01) mechanism.
What types of projects are generally expected under an R01 for this topic?
The R01 mechanism is generally intended for mature, hypothesis-driven projects with a well-developed research plan. In the context of this FOA, that means well-formed studies designed to produce mechanistic understanding of dispersal and/or translate that understanding toward approaches that prevent, limit, or redirect invasion.
Is there a related opportunity for exploratory or earlier-stage work?
Yes. This announcement runs in parallel with a companion announcement (PAS 08 049) that uses the R21 Exploratory/Developmental mechanism and has the same scientific scope, offering a path for earlier-stage or higher-risk concept testing.
What are the main scientific themes of the FOA?
The scientific goals are organized around three connected themes: (1) intrinsic properties of brain tumor cells that drive migration, (2) the role of the normal brain microenvironment in shaping tumor movement, and (3) translating insights into interventions to prevent, limit, or redirect dispersal.
What does the FOA mean by "intrinsic properties" that drive tumor cell migration?
Intrinsic properties refer to cell-level features of brain tumor cells that make them capable of moving through brain tissue. Examples listed include molecular pathways, cytoskeletal dynamics, adhesion properties, protease activity, metabolic adaptations, and other traits that enable motility in the unique brain environment.
How does the FOA describe the importance of the normal brain microenvironment?
The FOA emphasizes that invasion is not only a tumor-cell program. It is also influenced by the surrounding brain tissue and how tumor cells interact with normal brain elements and structures.
Which brain microenvironment components are specifically mentioned as influencing dispersal?
The FOA mentions interactions with neurons, glia (including astrocytes and oligodendrocytes), microglia/macrophages, endothelial cells and blood vessels, extracellular matrix components, and structural routes such as white matter tracts.
What kind of "interventions" does the FOA encourage?
The FOA explicitly encourages translation of findings into interventions, meaning approaches that use what is learned about migration and microenvironmental interactions to design therapies or strategies that prevent, limit, or redirect dispersal. A stated focus is targeting invading tumor cells rather than only shrinking the primary tumor core.
Does the FOA focus only on reducing the main tumor mass?
No. A central emphasis is that effective strategies should address invasive tumor cells that escape the main tumor, not just treatments aimed at shrinking the tumor core.
Which NIH institutes are involved in funding decisions?
The National Institute of Neurological Disorders and Stroke (NINDS) set aside funds for this announcement (in combination with the parallel R21), and the National Cancer Institute (NCI) is also involved and indicates it will consider both programmatic priority and scientific merit.
How much funding was set aside for this announcement?
NINDS set aside a combined total of $400,000 per year in total costs for this R01 announcement and the parallel R21 announcement.
Is the set-aside funding the only money available for awards?
No. The set-aside funds are described as being in addition to funds available for applications that score within the standard NINDS payline.
Are award size, duration, or the number of awards fixed?
No. The FOA states that award size, duration, total dollars, and number of awards are not fixed and will depend on factors such as the number of applications received, their quality, requested budgets, project periods, scientific merit, relevance, and funds availability over the life of the announcement.
What research areas does this opportunity relate to?
The funding activity falls within health and research areas connected to cancer and neuroscience.
What CFDA listings are associated with this opportunity?
The CFDA listings provided are 93.393 (Cancer Cause and Prevention Research) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and various government entities (state, county, city/township, special districts, independent school districts, and public housing authorities/Indian housing authorities).
Can foreign institutions apply?
Yes. The eligibility language states that foreign institutions may apply.
Are U.S. federal agencies eligible to apply?
Yes. The eligibility language indicates that eligible federal agencies may apply.
Are faith-based or community-based organizations eligible?
Yes. The opportunity states that faith-based or community-based organizations may apply.
Are Native American tribal governments or tribal organizations eligible?
Yes. Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments) are listed among eligible applicants.
When was this funding opportunity posted?
The opportunity was posted on December 17, 2007.
What was the closing date for applications?
The original and current closing date listed is January 7, 2011.
When was the opportunity archived?
The archive date listed is February 7, 2011.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full text of the announcement made available?
The full text was made available through the NIH Grants Guide at the link referenced in the announcement description.
Who should be contacted for access or technical issues related to the announcement?
For access or technical issues, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAS 08 048) also looked into and applied for these:
| Funding Opportunity |
|---|
| Understanding and Preventing Brain Tumor Dispersal (R21) Apply for PAS 08 049 Funding Number: PAS 08 049 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Long Acting, Sustainable Therapies for Opiate Addiction (R01) Apply for PAS 08 061 Funding Number: PAS 08 061 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Alzheimer s Disease Pilot Clinical Trials (R01) Apply for PAR 08 062 Funding Number: PAR 08 062 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Decision Making in Cancer Single Event Decisions (R01) Apply for PA 08 063 Funding Number: PA 08 063 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Decision Making in Cancer Single Event Decisions (R21) Apply for PA 08 064 Funding Number: PA 08 064 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research on the Economics of Diet, Activity and Energy Balance (R21) Apply for PA 08 077 Funding Number: PA 08 077 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| NLM Express Research Grants in Biomedical Informatics (R01) Apply for PAR 08 080 Funding Number: PAR 08 080 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R21) Apply for PA 08 084 Funding Number: PA 08 084 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R03) Apply for PA 08 085 Funding Number: PA 08 085 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Functional Links between the Immune System, Brain Function and Behavior (R01) Apply for PA 08 097 Funding Number: PA 08 097 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Functional Links between the Immune System, Brain Function and Behavior (R21) Apply for PA 08 098 Funding Number: PA 08 098 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Cancer Education Grants Program (R25) Apply for PAR 08 120 Funding Number: PAR 08 120 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Symptom Interactions in Cancer and Immune Disorders (R01) Apply for PA 08 121 Funding Number: PA 08 121 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Symptom Interactions in Cancer and Immune Disorders (R21) Apply for PA 08 122 Funding Number: PA 08 122 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Epidemiology Of Drug Abuse (R01) Apply for PA 08 124 Funding Number: PA 08 124 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Epidemiology Of Drug Abuse (R21) Apply for PA 08 125 Funding Number: PA 08 125 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Epidemiology Of Drug Abuse (R03) Apply for PA 08 126 Funding Number: PA 08 126 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01) Apply for PA 08 131 Funding Number: PA 08 131 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R21) Apply for PA 08 132 Funding Number: PA 08 132 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Prescription Drug Misuse (R01) Apply for PA 08 127 Funding Number: PA 08 127 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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