Opportunity Information: Apply for PA 15 271
Apply for PA 15 271
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Understanding HIV Persistence in Infants (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jun 5, 2015 and posted on Jun 5, 2015.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments Native American tribal governments (Federally recognized) Small businesses State governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Understanding HIV Persistence in Infants (R01)" (Funding Opportunity Number PA-15-271) is a National Institutes of Health discretionary research grant designed to push forward basic and translational science on why HIV-1 can persist in infants who acquire infection around the time of birth. The central scientific focus is the pathogenesis of perinatal HIV-1 infection, with particular emphasis on how HIV-specific immune responses develop and function within an infant's rapidly evolving immune system, and how HIV establishes and maintains latent viral reservoirs early in life. By encouraging studies that clarify these immune and reservoir dynamics, the program aims to generate knowledge that can later be used to design and test strategies intended to induce HIV-1 remission, meaning durable control of the virus without continuous antiretroviral therapy.
This FOA sits within NIH's health research mission and is tied to two CFDA program areas: 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). It uses the R01 mechanism, which is NIH's standard investigator-initiated research project grant and typically supports a defined, hypothesis-driven set of aims led by a principal investigator. The announcement explicitly indicates there is no cost sharing or matching requirement, which means applicants are not expected to contribute non-federal funds as a condition of receiving an award.
In practical terms, the opportunity is aimed at researchers proposing projects that can shed light on two connected problems that are especially important in infants: first, how infant immune responses to HIV-1 emerge and operate in early life (a period when immune cells and immune regulation differ meaningfully from older children and adults), and second, how HIV-1 manages to seed, establish, and persist in latent reservoirs in that unique biological setting. Work supported under this FOA could reasonably include careful characterization of infant immune ontogeny as it relates to HIV infection, identification of immune correlates that might influence reservoir formation, and mechanistic studies of viral latency and persistence that take into account the distinctive features of neonatal and infant immunity. The long-term payoff NIH is signaling is to build a foundation for future interventions that move beyond lifelong suppression and toward remission-oriented approaches tailored to infants.
Eligibility is broad and includes a wide array of U.S. and non-U.S. organizations. Eligible applicants include nonprofit organizations (both with and without 501(c)(3) status), public and private institutions of higher education, for-profit organizations (including small businesses, and also for-profits other than small businesses), state and local governments (including county governments, city or township governments, and special district governments), independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and organizations (including federally recognized tribal governments and other tribal organizations). The FOA also calls out additional eligible applicants such as Historically Black Colleges and Universities, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions, faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, foreign organizations (non-U.S. entities), and regional organizations. This wide eligibility scope reflects the global and cross-sector nature of pediatric HIV research, and it allows collaborations that may be critical for accessing relevant cohorts, specimens, and clinical data.
From an administrative standpoint, the announcement was posted and created on June 5, 2015. The original and current closing date listed is January 7, 2016, and the archive date is February 7, 2016, indicating that this particular FOA is no longer active for new submissions under those dates. The sponsoring agency is the National Institutes of Health, and the full announcement was made available through an NIH grants guide link (http://grants.nih.gov/grants/guide/pa-files/PA-15-271.html). For access issues or technical problems reaching the online materials, the FOA directs applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PA-15-271 is a targeted R01 funding call meant to deepen the field's understanding of infant HIV persistence by connecting detailed immunology in early life with the biology of latent reservoir establishment and maintenance. NIH frames this as groundwork that can enable later development of remission-focused strategies, which is a particularly high-impact goal in perinatal infection where early-life treatment and immune development may create different opportunities and constraints than in adult infection.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Understanding HIV Persistence in Infants (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-15-271.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is used?
This FOA uses the R01 mechanism, NIH's standard investigator-initiated research project grant that typically supports a defined, hypothesis-driven set of aims led by a principal investigator.
What is the overall purpose of this FOA?
The purpose is to advance basic and translational research on why HIV-1 can persist in infants infected around the time of birth, with the goal of generating knowledge that can later support strategies aimed at HIV-1 remission (durable viral control without continuous antiretroviral therapy).
What is the central scientific focus of the program?
The central focus is the pathogenesis of perinatal HIV-1 infection, especially how HIV-specific immune responses develop and function in infants and how HIV establishes and maintains latent viral reservoirs early in life.
What two connected scientific problems does the FOA emphasize?
The FOA highlights two linked areas that are especially important in infants: (1) how infant immune responses to HIV-1 emerge and operate during early life, and (2) how HIV-1 seeds, establishes, and persists in latent reservoirs within that unique early-life immune environment.
How does infant biology factor into the research focus?
The FOA emphasizes that infancy is a period of rapidly evolving immune development, where immune cells and immune regulation can differ meaningfully from older children and adults, potentially shaping both immune responses to HIV and early reservoir formation.
What kinds of studies are considered responsive to this FOA?
Based on the description, responsive work could include research that clarifies infant immune ontogeny as it relates to HIV infection, identifies immune correlates that may influence reservoir formation, and conducts mechanistic studies of viral latency and persistence that account for distinctive features of neonatal and infant immunity.
Does the FOA support basic research, translational research, or both?
It is intended to push forward both basic and translational science related to HIV persistence and reservoir biology in infants.
What does the FOA mean by "HIV-1 remission"?
In this context, remission means durable control of HIV-1 without continuous antiretroviral therapy.
Is this FOA intended to directly fund remission-inducing interventions?
The FOA is framed as building the foundational knowledge needed to design and test future remission-oriented strategies, by first clarifying immune and reservoir dynamics in infants.
Which CFDA program areas are associated with this FOA?
This FOA is tied to two CFDA program areas: 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is there a cost sharing or matching requirement?
No. The announcement explicitly states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes a wide range of U.S. and non-U.S. organizations, including nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, for-profit organizations (including small businesses and other for-profits), and various government entities and other eligible organizations.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA explicitly includes foreign organizations (non-U.S. entities) as eligible applicants.
Are state and local government entities eligible?
Yes. Eligible applicants include state and local governments, including county governments, city or township governments, and special district governments.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes Native American tribal governments (including federally recognized tribal governments) and other tribal organizations as eligible applicants.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA calls out several categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The FOA lists U.S. territories or possessions as eligible applicants.
When was this FOA posted?
The announcement was posted and created on June 5, 2015.
What was the application closing date listed for this FOA?
The original and current closing date listed is January 7, 2016.
Is this funding opportunity still active?
Based on the listed dates, it appears to be archived. The archive date is February 7, 2016, indicating it is no longer active for new submissions under those dates.
Where can I find the full FOA text?
The full announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-15-271.html
Who should be contacted for technical issues accessing the online materials?
For access issues or technical problems, the FOA directs applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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