Opportunity Information: Apply for RFA HD 17 011
Apply for RFA HD 17 011
- The HHS-NIH11 in the health, income security and social services sector is offering a public funding opportunity titled "Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865,.
- This funding opportunity was created on Jun 07, 2016 and posted on Jun 07, 2016.
- Applicants must submit their applications by Aug 17, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R01)" (Funding Opportunity Number RFA-HD-17-011) is a discretionary NIH research grant that supports studies aimed at clarifying how sexually transmitted infections (STIs) and HIV influence one another in adolescents and young adults. The central scientific focus is on what happens at mucosal surfaces, specifically in the genital tract and the gastrointestinal (GI) tract, because these tissues are major sites of exposure, transmission risk, and early immune responses. By encouraging research that examines these local tissue environments, the FOA is intended to build a clearer mechanistic picture of why STI co-infections can increase vulnerability to HIV acquisition, affect HIV replication or persistence, and potentially shape disease progression in youth.
A key emphasis of this announcement is improving understanding of HIV and STI interactions in populations that are either at risk for HIV or already living with HIV, with an explicit focus on adolescents and young adults. This matters because adolescents are not simply "small adults" biologically or behaviorally: puberty-associated hormonal changes, evolving mucosal immunity, differences in genital tract microbiology, and developmental and social factors can all influence susceptibility to infection and the course of co-infections. The FOA highlights the adolescent genital and GI mucosa because these compartments can differ substantially in immune cell composition, inflammatory responses, epithelial integrity, and microbial communities, all of which may be altered by STIs and in turn affect HIV transmission dynamics and local viral activity.
The funding mechanism is an NIH R01, meaning applicants are expected to propose a substantial, hypothesis-driven research project with clear aims, rigorous methods, and a plan for producing generalizable knowledge. The agency listed is HHS-NIH (AgencyName: HHS-NIH11), and the activity category is Health, Income Security, and Social Services. The associated CFDA numbers are 93.865, indicating the program area under which the award is cataloged. The opportunity was created and posted on June 7, 2016, with an original and current closing date of August 17, 2016, reflecting a single application due date for that cycle.
In terms of budget, the award ceiling is listed as $300,000, which typically signals the maximum direct costs allowed per year or per project (depending on the specific FOA instructions), and applicants would need to design a project that fits within that cap while still being scientifically compelling and feasible. The FOA also lists "ExpectedAwards:" without a number provided in the source data here, so the announcement did not specify in this excerpt how many awards NIH anticipated making, which can vary year to year based on available funds and application quality.
Eligibility is broad and includes a wide range of domestic applicant organizations. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and additional entities described under an "Others" category referenced in the FOA text for clarification. This wide eligibility scope suggests NIH was seeking to attract multidisciplinary teams from academic medical centers, public health entities, community-linked organizations, and potentially industry partners capable of contributing specialized assays, diagnostics, or translational approaches.
Overall, the purpose of the FOA is to stimulate research that can explain the biological and immunological interplay between HIV and other STIs in young people at the mucosal level, with the longer-term implication that better mechanistic understanding can inform prevention strategies, diagnostic approaches, and interventions tailored to adolescents and young adults. By centering on the genital and GI mucosa, the opportunity points investigators toward studying local inflammation, mucosal immune activation, epithelial barrier function, and other tissue-specific processes that are directly relevant to HIV susceptibility and transmission in the context of common STI co-infections.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-HD-17-011.
What type of grant is this (mechanism)?
This is an NIH R01 research project grant, intended for substantial, hypothesis-driven studies with clear aims and rigorous methods.
Which agency is offering this grant?
The agency listed is HHS-NIH (AgencyName: HHS-NIH11).
What is the overall purpose of this funding opportunity?
The purpose is to support studies that clarify how sexually transmitted infections (STIs) and HIV influence one another in adolescents and young adults, with an emphasis on understanding these interactions at mucosal surfaces.
What scientific areas or research themes does the FOA emphasize?
The FOA emphasizes mechanistic research on HIV/STI interactions at mucosal surfaces, especially how STI co-infections may increase vulnerability to HIV acquisition, affect HIV replication or persistence, and potentially shape disease progression in youth.
Which tissues or body compartments are the main focus of the research?
The central focus is on mucosal surfaces, specifically the genital tract and the gastrointestinal (GI) tract, because these are major sites of exposure, transmission risk, and early immune responses.
Why does the FOA focus on the genital and GI mucosa?
These compartments are highlighted because they can differ substantially in immune cell composition, inflammatory responses, epithelial integrity, and microbial communities, and these local factors may be altered by STIs and can influence HIV transmission dynamics and local viral activity.
Who is the intended population for the research supported by this grant?
The intended populations are adolescents and young adults who are either at risk for HIV or already living with HIV, with a specific emphasis on understanding HIV and STI interactions in these youth populations.
Why are adolescents and young adults treated as a distinct focus in this FOA?
The FOA notes that adolescents are not simply "small adults." Puberty-associated hormonal changes, evolving mucosal immunity, differences in genital tract microbiology, and developmental and social factors can affect susceptibility to infection and the course of co-infections.
What kinds of biological processes does the FOA suggest investigators examine?
It points investigators toward studying tissue-specific processes such as local inflammation, mucosal immune activation, epithelial barrier function, and other mechanisms at genital and GI mucosal sites that are directly relevant to HIV susceptibility and transmission in the context of STIs.
What is the application due date for this opportunity?
The original and current closing date listed is August 17, 2016, reflecting a single application due date for that cycle.
When was this opportunity created and posted?
The opportunity was created and posted on June 7, 2016.
What is the award ceiling (maximum budget) listed in the excerpt?
The award ceiling is listed as $300,000. This typically signals a maximum direct cost amount per year or per project, depending on the specific FOA instructions.
Does the excerpt specify how many awards NIH expects to make?
No. The excerpt shows "ExpectedAwards:" without a number, so the number of anticipated awards is not specified in the provided source data.
What is the CFDA number associated with this opportunity?
The associated CFDA number listed is 93.865.
What is the activity category associated with this opportunity?
The activity category is listed as Health, Income Security, and Social Services.
Which types of organizations are eligible to apply?
Eligibility is broad and includes many domestic organization types, including state, county, city, or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and additional entities described under an "Others" category referenced in the FOA text.
Are for-profit organizations eligible to apply?
Yes. The eligibility list includes for-profit organizations other than small businesses, as well as small businesses.
Are colleges and universities eligible to apply?
Yes. Eligible applicants include both public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal entities included in the eligibility list?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are included as eligible applicants.
Are local government entities eligible to apply?
Yes. The eligibility list includes state governments, county governments, and city or township governments, as well as special district governments.
Are nonprofits eligible to apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are included, with a note that those nonprofit categories exclude institutions of higher education.
Does the FOA indicate what kinds of teams or partners NIH hopes to attract?
Based on the wide eligibility scope described, the FOA appears intended to attract multidisciplinary teams from academic medical centers, public health entities, community-linked organizations, and potentially industry partners that can contribute specialized assays, diagnostics, or translational approaches.
What longer-term impact does the FOA aim to support?
By improving mechanistic understanding of HIV and STI interactions at mucosal sites in youth, the FOA aims to generate knowledge that can inform prevention strategies, diagnostic approaches, and interventions tailored to adolescents and young adults.
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