Opportunity Information: Apply for PAR 13 241
Apply for PAR 13 241
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Unveiling the Genome Genetic Architecture of Severe Mental Disorders Revealed (Collaborative U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Feb 20, 2015 and posted on Jun 7, 2013.
- Applicants must submit their applications by Feb 20, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Private institutions of higher education For profit organizations other than small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments State governments Independent school districts Native American tribal governments (Federally recognized) Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity PAR 13-241, titled "Unveiling the Genome Genetic Architecture of Severe Mental Disorders Revealed (Collaborative U01)," is a discretionary grant program offered as a cooperative agreement (U01) to support a consortium-style research effort focused on severe mental disorders. The central aim is to move beyond partial genetic signals and work toward a more complete picture of genetic susceptibility by generating and analyzing whole genome sequencing (WGS) data at high resolution. Projects funded under this announcement are expected to use modern, cutting-edge sequencing approaches and pair those data with innovative or novel statistical methods capable of extracting meaningful insights from genome-wide variation, including rare and structural variation that older genotyping approaches often miss.
A defining feature of this FOA is its emphasis on collaboration and scale. Applicants are expected to form a consortium of collaborative projects with a minimum of two research sites, reflecting the reality that large, well-characterized datasets and coordinated analytic pipelines are usually necessary to detect and interpret the complex genetic architecture of severe mental disorders. The scientific strategy envisioned here involves either case-control samples (comparing affected individuals to unaffected controls) or family-based samples (leveraging inheritance patterns within families). Both designs can be powerful for different reasons: case-control datasets can provide broad statistical power for association testing, while family samples can strengthen causal inference and help identify rare inherited or de novo variants that may contribute to disease risk.
The work supported is oriented around the concept of "full genetic architecture," meaning a comprehensive accounting of the different kinds of genetic variation that influence risk. With WGS, the consortium can interrogate common single-nucleotide variants, rare variants, insertions and deletions, and potentially larger structural changes across the entire genome, including noncoding and regulatory regions. The FOA underscores that progress will come not only from generating WGS data, but also from deploying state-of-the-art assays and advanced analytical frameworks. That includes developing or applying statistical methods designed for genome-wide rare variant analyses, multi-variant and gene-based testing, integrative models that combine different classes of variants, and approaches that can address heterogeneity across sites and populations.
Administratively, this opportunity is listed under CFDA 93.242 (Mental Health Research Grants) and is managed by the National Institutes of Health. The funding instrument is explicitly a cooperative agreement, which generally signals substantial NIH programmatic involvement during the life of the award, often through coordination, milestone tracking, data-sharing expectations, and harmonization of methods across participating sites. The estimated total funding amount listed is $4,000,000. The FOA indicates no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of receiving an award.
Eligibility is broad and includes many types of domestic applicants: public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, and small businesses. Various government entities are eligible as well, including city or township governments, county governments, state governments, independent school districts, and special district governments, along with public housing authorities/Indian housing authorities. The announcement also explicitly includes tribal organizations and tribal governments (federally recognized and other than federally recognized), as well as tribally controlled colleges and universities.
The FOA goes further by clarifying that additional eligible applicants include a wide set of institution types and community-oriented organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations. Importantly, the eligibility language allows non-U.S. entities and foreign institutions to apply, and it also allows foreign components of U.S. organizations, consistent with NIH policy definitions. Regional organizations and U.S. territories or possessions are also included. This broad eligibility supports the consortium model and encourages inclusion of diverse populations and international expertise, which can be essential for improving discovery and generalizability in psychiatric genomics.
In terms of timing and status, the FOA was posted June 7, 2013, and later archived, with an archive date of March 20, 2015. The original closing date is listed as October 15, 2015, while the dataset provided also lists a current closing date of February 20, 2015, along with a creation date of February 20, 2015, suggesting the record reflects archived or updated administrative metadata rather than an open competition today. Applicants seeking the full details were directed to the NIH Grants Guide page associated with PAR 13-241, and contact support for access or linking issues is handled through the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
Overall, this opportunity was designed to accelerate discovery in the genetics of severe mental disorders by funding multi-site teams that can produce high-quality WGS datasets and apply advanced, sometimes newly developed analytic approaches to identify risk-related genomic variation. The consortium structure, WGS focus, and emphasis on novel statistical methodology together signal a push toward deeper, more comprehensive genetic insight than earlier genome-wide association or candidate gene strategies could typically deliver.
FAQs: NIH PAR 13-241 - "Unveiling the Genome Genetic Architecture of Severe Mental Disorders Revealed (Collaborative U01)"
What is the name and number of this NIH funding opportunity?
The funding opportunity is NIH PAR 13-241, titled "Unveiling the Genome Genetic Architecture of Severe Mental Disorders Revealed (Collaborative U01)."
What type of award is PAR 13-241?
It is a discretionary grant program using the cooperative agreement mechanism, specifically a U01. A cooperative agreement generally indicates substantial NIH programmatic involvement during the award period.
What is the main scientific goal of this FOA?
The central aim is to move beyond partial genetic signals and work toward a more complete picture of genetic susceptibility to severe mental disorders by generating and analyzing high-resolution whole genome sequencing (WGS) data.
What does the FOA mean by "full genetic architecture"?
"Full genetic architecture" refers to a comprehensive accounting of different kinds of genetic variation that influence risk, including common variants, rare variants, insertions and deletions, and potentially larger structural changes across the genome, including noncoding and regulatory regions.
Why is whole genome sequencing (WGS) emphasized in this opportunity?
WGS allows the consortium to interrogate genome-wide variation at high resolution, including rare and structural variation that older genotyping approaches often miss, and it supports analysis of both coding and noncoding regions.
What kinds of genetic variation are projects expected to study using WGS?
Projects are expected to examine genome-wide variation, including common single-nucleotide variants, rare variants, insertions and deletions, and potentially larger structural changes, including variation in noncoding and regulatory regions.
What kinds of study designs are envisioned for the samples?
The FOA envisions either case-control samples (affected individuals compared to unaffected controls) or family-based samples (using inheritance patterns within families). Both approaches are described as powerful but for different reasons.
How does the FOA describe the strengths of case-control versus family-based samples?
Case-control datasets can provide broad statistical power for association testing, while family-based samples can strengthen causal inference and help identify rare inherited or de novo variants that may contribute to disease risk.
Is collaboration required?
Yes. A defining feature is collaboration and scale, with applicants expected to form a consortium of collaborative projects.
How many research sites are required for the consortium?
The consortium is expected to include a minimum of two research sites.
What kinds of methods and analyses does the FOA expect?
Projects are expected to pair cutting-edge sequencing approaches with innovative or novel statistical methods capable of extracting meaningful insights from genome-wide variation, including rare and structural variation.
What types of statistical approaches are specifically encouraged?
The FOA highlights advanced analytical frameworks such as genome-wide rare variant analyses, multi-variant and gene-based testing, integrative models combining different classes of variants, and approaches that can address heterogeneity across sites and populations.
Does the FOA focus only on generating data, or also on analytics?
It emphasizes both. Progress is framed as coming not only from generating WGS data, but also from deploying state-of-the-art assays and advanced analytical frameworks, including development or application of new methods.
What is the CFDA number associated with this opportunity?
The opportunity is listed under CFDA 93.242 (Mental Health Research Grants).
Which federal agency manages this program?
It is managed by the National Institutes of Health (NIH).
How much total funding is estimated under this FOA?
The estimated total funding amount listed is $4,000,000.
Is cost sharing or matching required?
No. The FOA indicates there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving an award.
What does it mean that this is a cooperative agreement (U01) rather than a standard grant?
The FOA notes that a cooperative agreement generally signals substantial NIH programmatic involvement during the award, often including coordination, milestone tracking, data-sharing expectations, and harmonization of methods across participating sites.
What types of organizations are eligible to apply?
Eligibility is broad and includes many types of domestic applicants, such as public and private institutions of higher education, nonprofit organizations (501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, and small businesses.
Are government entities eligible applicants?
Yes. Eligible government entities include city or township governments, county governments, state governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes tribal organizations and tribal governments (federally recognized and other than federally recognized), as well as tribally controlled colleges and universities.
Does the FOA encourage or allow applications from minority-serving institutions and community-based organizations?
Yes. The eligibility language includes Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations.
Are non-U.S. or foreign institutions eligible to apply?
Yes. The FOA allows non-U.S. entities and foreign institutions to apply, and it also allows foreign components of U.S. organizations, consistent with NIH policy definitions.
Are U.S. territories or possessions included in the eligibility?
Yes. Regional organizations and U.S. territories or possessions are included in the eligibility description.
When was this FOA posted, and what is its current status?
The FOA was posted on June 7, 2013, and it was later archived with an archive date of March 20, 2015.
What are the listed closing dates, and what do they suggest?
The original closing date is listed as October 15, 2015. The dataset also lists a current closing date of February 20, 2015, along with a creation date of February 20, 2015. This combination suggests the record reflects archived or updated administrative metadata rather than an open competition today.
Where were applicants directed to find full details about PAR 13-241?
Applicants were directed to the NIH Grants Guide page associated with PAR 13-241 for full details.
Who should be contacted for access or linking issues related to the FOA page?
Contact support for access or linking issues is handled through the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What overall impact was this opportunity designed to have?
It was designed to accelerate discovery in the genetics of severe mental disorders by funding multi-site teams to produce high-quality WGS datasets and apply advanced (and sometimes newly developed) analytic approaches to identify risk-related genomic variation, pushing beyond earlier genome-wide association or candidate gene strategies.
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