Opportunity Information: Apply for PAR 16 135

  • The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Using the NIMH Research Domain Criteria (RDoC) Approach to Understand Psychosis (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
  • This funding opportunity was created on Mar 17, 2016 and posted on Mar 17, 2016.
  • Applicants must submit their applications by Mar 16, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PAR 16 135

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Opportunity Summary:

The grant opportunity titled "Using the NIMH Research Domain Criteria (RDoC) Approach to Understand Psychosis (R21)" (Funding Opportunity Number PAR-16-135) is a National Institute of Mental Health (NIMH) research funding announcement that supports exploratory, early-stage studies aimed at improving scientific understanding of psychosis. The core focus is on psychotic symptoms such as hallucinations, delusions, disorganized behavior, and thought disorder, with projects expected to use the NIMH Research Domain Criteria (RDoC) framework as the organizing approach for the research. In practical terms, this means NIMH is looking for studies that move beyond traditional diagnostic categories and instead investigate underlying neurobehavioral mechanisms and functional constructs that cut across disorders, linking behavior to brain and biological systems in a more dimensional, mechanism-centered way.

The mechanism for this opportunity is the NIH R21 grant, which is generally designed to fund innovative, developmental, and higher-risk projects that can generate foundational data or new directions for later, larger-scale research. The award ceiling listed is $200,000, indicating the maximum amount of funding that can be requested under this announcement (typically interpreted within standard NIH R21 budget rules). The activity category is Health, and the associated CFDA number is 93.242, aligning it with NIMH research and training support. The opportunity is offered by the U.S. Department of Health and Human Services under NIH (Agency name shown as HHS-NIH11).

Eligibility is broad and includes many organizational types that commonly participate in NIH-funded research. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; non-federally recognized tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses. The listing also notes that additional categories may apply as described in the full eligibility text, which is typical for NIH announcements that allow a wide range of domestic organizations to apply as long as they meet standard NIH requirements.

In terms of timing, the opportunity was created and posted on March 17, 2016, with an original and current closing date of March 16, 2017. The announcement lists "Expected Awards:" without a number, suggesting the total number of anticipated awards was not specified in the provided excerpt. Overall, the intent of this funding opportunity is to stimulate RDoC-aligned research that clarifies the mechanisms that contribute to psychotic experiences and related behavioral and cognitive disruptions, ideally producing insights that can later inform improved measurement, prediction, prevention strategies, or intervention development grounded in neurobehavioral science rather than only symptom-based diagnostic groupings.

Frequently Asked Questions (FAQs)

What is the title of this grant opportunity?

The opportunity is titled "Using the NIMH Research Domain Criteria (RDoC) Approach to Understand Psychosis (R21)."

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is PAR-16-135.

Which agency is offering this grant?

This is a National Institute of Mental Health (NIMH) funding announcement under the National Institutes of Health (NIH), within the U.S. Department of Health and Human Services (HHS). The agency name is shown as HHS-NIH11.

What is the main purpose of this funding opportunity?

The purpose is to support exploratory, early-stage research that improves scientific understanding of psychosis by using the NIMH Research Domain Criteria (RDoC) framework as the organizing approach.

What kinds of psychosis-related symptoms are emphasized?

The announcement highlights psychotic symptoms such as hallucinations, delusions, disorganized behavior, and thought disorder.

What research framework is required or expected for projects under this opportunity?

Projects are expected to use the NIMH Research Domain Criteria (RDoC) framework as the organizing approach for the research.

What does it mean to use the RDoC approach in this context?

Using RDoC means moving beyond traditional diagnostic categories and instead investigating underlying neurobehavioral mechanisms and functional constructs that can cut across disorders, linking behavior to brain and biological systems in a more dimensional, mechanism-centered way.

What grant mechanism is used for this opportunity?

The mechanism is the NIH R21 grant.

What type of projects is the R21 mechanism designed to support?

R21 awards are generally intended for innovative, developmental, and higher-risk projects that can generate foundational data or open new research directions that may support later, larger-scale studies.

What is the maximum funding amount (award ceiling) listed?

The award ceiling listed is $200,000, described as the maximum amount that can be requested under this announcement (typically interpreted within standard NIH R21 budget rules).

What is the activity category for this opportunity?

The activity category is Health.

What is the CFDA number associated with this funding opportunity?

The CFDA number is 93.242.

Who is eligible to apply?

Eligibility is broad and includes many organization types that commonly participate in NIH-funded research, including:

  • State governments
  • County governments
  • Local governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Federally recognized Native American tribal governments
  • Non-federally recognized tribal organizations
  • Public housing authorities
  • Indian housing authorities
  • Nonprofit organizations with 501(c)(3) status (other than institutions of higher education in those categories)
  • Nonprofit organizations without 501(c)(3) status (other than institutions of higher education in those categories)
  • For-profit organizations other than small businesses
  • Small businesses

Does the announcement suggest there may be additional eligible applicant categories?

Yes. The listing notes that additional categories may apply as described in the full eligibility text, which is common in NIH announcements that allow a wide range of domestic organizations to apply as long as they meet standard NIH requirements.

When was this funding opportunity created and posted?

The opportunity was created and posted on March 17, 2016.

What is the closing date for this opportunity?

The original and current closing date listed is March 16, 2017.

How many awards are expected to be made?

The announcement lists "Expected Awards:" without providing a number, meaning the anticipated number of awards is not specified in the provided information.

What kinds of outcomes or longer-term goals does NIMH appear to be aiming for with this opportunity?

Based on the description, the intent is to stimulate RDoC-aligned research that clarifies mechanisms contributing to psychotic experiences and related behavioral and cognitive disruptions, ideally producing insights that could later support improved measurement, prediction, prevention strategies, or intervention development grounded in neurobehavioral science rather than only symptom-based diagnostic groupings.

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Previous opportunity: Advanced Rehabilitation Research Training (ARRT) Program - Employment

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