Opportunity Information: Apply for PAS 10 183
Apply for PAS 10 183
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Validation of Novel Therapeutic Targets for Huntingtons Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Apr 30, 2010 and posted on Apr 30, 2010.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Independent school districts State governments County governments Public housing authorities/Indian housing authorities Small businesses Special district governments Private institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Validation of Novel Therapeutic Targets for Huntingtons Disease (R01) opportunity (Funding Opportunity Number PAS 10-183) is a National Institutes of Health program led by the National Institute of Neurological Disorders and Stroke (NINDS) that focuses specifically on moving potential Huntington's disease treatments closer to reality by validating new molecular targets. The central goal is to support research that can convincingly show that a particular gene, protein, pathway, or other molecular mechanism is not just associated with the disease, but is a credible, disease-modifying intervention point. In practice, this means projects are expected to generate strong evidence that manipulating the target can alter disease-relevant biology in a meaningful way, which is a key step before the field can justify major drug discovery or translational development efforts.
This funding announcement uses the NIH R01 mechanism, which is the standard research project grant intended for well-scoped, hypothesis-driven or milestone-driven biomedical research programs. A defining feature of this FOA is that it is intended to support new projects rather than continuing work that has already been started with NIH funds. In other words, the program is positioned to stimulate fresh, target-validation efforts rather than simply extending existing NIH-supported studies under a new umbrella.
The financial plan described in the announcement set aside an estimated total of $4.5 million in fiscal year 2011 to support approximately 3 to 4 awards, assuming an average of $250,000 per year in direct costs per project and an average project duration of four years. Like most NIH opportunities, actual awards depend on the availability of appropriated funds and the number and quality of applications received; the FOA notes that funding in later years would be contingent on future budgets and would be communicated through notices in the NIH Guide for Grants and Contracts.
The opportunity is categorized as discretionary grant funding in the health area and is listed under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). It does not require cost sharing or matching funds, which lowers administrative and financial barriers for many applicants and is typical for NIH research grants.
Eligibility is broad and includes many types of U.S. organizations and governmental entities, as well as certain non-U.S. entities. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and a range of government bodies such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities including Indian housing authorities. The FOA also explicitly includes a wide set of additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), tribal governments and tribal organizations (including some categories beyond federally recognized tribes), eligible federal agencies, regional organizations, and U.S. territories or possessions. Importantly, the eligibility list also includes non-domestic (non-U.S.) entities (foreign organizations), indicating that international research teams could apply if they meet NIH requirements and the project is aligned with program priorities.
From an administrative timeline perspective, the FOA was posted and created on April 30, 2010, with an original closing date of May 7, 2013, and a current closing date also listed as May 7, 2013. The archive date is June 7, 2013, meaning it is no longer an active open solicitation, but the record provides a clear snapshot of what NINDS was seeking during that period and how it structured support for target validation in Huntington's disease.
For applicants or readers looking for the full archived announcement, the FOA points to the NIH Grants Guide page (http://grants.nih.gov/grants/guide/pa-files/PAS-10-183.html). The contact information provided is for the NIH Office of Extramural Research (OER) webmaster, intended for technical problems accessing or linking to the announcement rather than scientific questions about project fit.
FAQs: Validation of Novel Therapeutic Targets for Huntington's Disease (R01) (PAS 10-183)
What is this funding opportunity?
This is an NIH Funding Opportunity Announcement (FOA) titled "Validation of Novel Therapeutic Targets for Huntington's Disease (R01)" with Funding Opportunity Number PAS 10-183. It is a National Institutes of Health program led by the National Institute of Neurological Disorders and Stroke (NINDS).
What is the main purpose of PAS 10-183?
The purpose is to move potential Huntington's disease treatments closer to reality by supporting research that validates new molecular therapeutic targets. The FOA emphasizes generating convincing evidence that a proposed target is a credible, disease-modifying intervention point, not merely associated with the disease.
What kinds of "targets" does the FOA focus on?
The FOA focuses on molecular targets such as genes, proteins, pathways, or other molecular mechanisms that could serve as intervention points for Huntington's disease.
What does "target validation" mean in this FOA?
In this FOA, target validation means producing strong evidence that manipulating the proposed target can alter disease-relevant biology in a meaningful way. The goal is to demonstrate credibility as a disease-modifying intervention point, helping justify later-stage drug discovery or translational development.
What grant mechanism is used?
This FOA uses the NIH R01 mechanism, which is the standard NIH research project grant mechanism for well-scoped, hypothesis-driven or milestone-driven biomedical research programs.
Is this FOA intended for new projects or ongoing NIH-funded work?
It is intended to support new projects rather than continuing work that has already been started with NIH funds. The FOA is positioned to stimulate fresh target-validation efforts rather than extend existing NIH-supported studies under a new umbrella.
How much funding was expected to be available?
The financial plan described an estimated total of $4.5 million in fiscal year 2011 to support the program.
How many awards were anticipated?
The FOA anticipated approximately 3 to 4 awards, depending on the number and quality of applications and the availability of appropriated funds.
What was the expected project budget and duration?
The FOA assumed an average of $250,000 per year in direct costs per project and an average project duration of four years.
Are future-year awards guaranteed?
No. Like most NIH opportunities, actual awards depend on the availability of appropriated funds and the number and quality of applications received. The FOA also notes that funding in later years would be contingent on future budgets and would be communicated through notices in the NIH Guide for Grants and Contracts.
Does this opportunity require cost sharing or matching funds?
No. The FOA states that it does not require cost sharing or matching funds.
What type of funding is this categorized as?
It is categorized as discretionary grant funding in the health area.
What CFDA number is associated with this opportunity?
The opportunity is listed under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Who can apply?
Eligibility is broad. Eligible applicants include many types of U.S. organizations and governmental entities, as well as certain non-U.S. entities. The FOA includes public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations); for-profit organizations (including small businesses and other for-profits); and multiple government bodies.
Which U.S. government entities are listed as eligible?
The FOA lists state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities (including Indian housing authorities) as eligible.
Are tribal entities and tribal-serving organizations eligible?
Yes. The FOA explicitly includes tribal governments and tribal organizations (including some categories beyond federally recognized tribes), along with tribally controlled colleges and universities (TCCUs).
Are minority-serving institutions included?
Yes. The FOA explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), and tribally controlled colleges and universities (TCCUs).
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among eligible applicant types.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list includes non-domestic (non-U.S.) entities (foreign organizations), indicating that international research teams could apply if they meet NIH requirements and the project aligns with program priorities.
When was the FOA posted, and what were the closing and archive dates?
The FOA was posted/created on April 30, 2010. The original closing date was May 7, 2013, and the current closing date is also listed as May 7, 2013. The archive date is June 7, 2013.
Is PAS 10-183 currently open for applications?
No. Because the archive date is June 7, 2013, this FOA is no longer an active open solicitation. The archived record provides a snapshot of what NINDS sought during that period.
Where can I find the full archived FOA announcement?
The FOA points to the NIH Grants Guide page: http://grants.nih.gov/grants/guide/pa-files/PAS-10-183.html
Who is the listed contact, and what are they for?
The contact information provided is for the NIH Office of Extramural Research (OER) webmaster. It is intended for technical problems accessing or linking to the announcement, not for scientific questions about project fit.
What disease area does this FOA address?
The FOA specifically targets Huntington's disease, with the aim of validating novel therapeutic targets that could support disease-modifying interventions.
What NIH institute leads this program?
The program is led by the National Institute of Neurological Disorders and Stroke (NINDS).
What is the key outcome the FOA is trying to enable for the field?
The FOA aims to produce enough credible evidence around specific targets so the field can justify major drug discovery or translational development efforts focused on those validated intervention points.
Browse more opportunities from the same agency: National Institutes of Health
Browse more opportunities from the same category: Health
Next opportunity: Disability and Rehabilitation Research Projects and Centers Program Disability Rehabilitation Research Projects (DRRPs) Transition to Employment CFDA Number 84.133A 1
Previous opportunity: Civic Participation Program
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAS 10 183
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAS 10 183) also looked into and applied for these:
| Funding Opportunity |
|---|
| Surveillance of Neural Tube Defects (NTDs) and Other Birth Defects in Low and Middle Income Countries Apply for CDC RFA DD10 1010 Funding Number: CDC RFA DD10 1010 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $150,000 |
| Increase Awareness of Alveolar Capillary Dysplasia (ACD) Among Health Care Providers Apply for CDC RFA DD10 1008 Funding Number: CDC RFA DD10 1008 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $200,000 |
| Partnerships for Development of New Therapeutic Classes for Select Viral and Bacterial Pathogens (R01) Apply for RFA AI 10 010 Funding Number: RFA AI 10 010 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Innovative Strategies for Serving Children and Youth with Epilepsy (Project Access) Apply for HRSA 10 100 Funding Number: HRSA 10 100 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Service Area Competition Additional Areas (SAC AA) Apply for HRSA 10 223 Funding Number: HRSA 10 223 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| American Red Cross, San Juan Puerto Rico Apply for CDC RFA CK 10 006E Funding Number: CDC RFA CK 10 006E Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Asthma and Indoor and Outdoor Air Quality Education Program Apply for CDC RFA EH10 1007 Funding Number: CDC RFA EH10 1007 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $125,000 |
| Teenage Pregnancy Prevention Integrating Services, Programs, and Strategies through Community wide Initiatives Apply for CDC RFA DP10 1009 Funding Number: CDC RFA DP10 1009 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,500,000 |
| NIAID Clinical Trial Planning Grant (R34) Apply for PAR 10 185 Funding Number: PAR 10 185 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAID Clinical Trial Implementation Cooperative Agreement (U01) Apply for PAR 10 186 Funding Number: PAR 10 186 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAID Clinical Trial Implementation Grant (R01) Apply for PAR 10 184 Funding Number: PAR 10 184 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Program Project on Alcohol Related Research (P01) Apply for PAR 10 187 Funding Number: PAR 10 187 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tribal Tobacco Control Programs to Reduce Commercial Tobacco Use Among American Indians and Alaska Natives Apply for CDC RFA DP10 1002 Funding Number: CDC RFA DP10 1002 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $340,000 |
| Telehealth Resource Center Grant Program Apply for HRSA 10 151 Funding Number: HRSA 10 151 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| First Time Motherhood/New Parents Initiative Apply for HRSA 10 035 Funding Number: HRSA 10 035 Agency: Health Resources and Services Administration Category: Health Funding Amount: $500,000 |
| Telehealth Network Grant Program Apply for HRSA 10 213 Funding Number: HRSA 10 213 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| MCH Research Network Programs Apply for HRSA 10 163 Funding Number: HRSA 10 163 Agency: Health Resources and Services Administration Category: Health Funding Amount: $150,000 |
| Funded Community Health Centers and Title X Programs Apply for CDC RFA DD10 1006 Funding Number: CDC RFA DD10 1006 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $275,000 |
| Occupational Safety and Health Research (R01) Apply for PAR 10 188 Funding Number: PAR 10 188 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Public Health Training Center Apply for HRSA 10 270 Funding Number: HRSA 10 270 Agency: Health Resources and Services Administration Category: Health Funding Amount: $650,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAS 10 183", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.