Opportunity Information: Apply for RFA MH 11 020
Apply for RFA MH 11 020
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Viral and Host Genetic Factors Regulating HIV Associated CNS Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Jul 29, 2010 and posted on Jul 29, 2010.
- Applicants must submit their applications by Jan 6, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses State governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Special district governments Small businesses County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This NIH funding opportunity, RFA MH 11 020 titled "Viral and Host Genetic Factors Regulating HIV Associated CNS Disease (R01)," supports research aimed at understanding why HIV 1 Associated Neurocognitive Disorders (HAND) continue to affect a large share of people living with HIV even in the era of highly active antiretroviral therapy (HAART). The core problem the FOA highlights is that clinical studies show more than half of HIV infected patients may still show signs of neurocognitive impairment despite treatment. NIMH and NINDS are looking for projects that dig into the genetic and genomic reasons behind this persistence, with special emphasis on how viral factors, host factors, and antiretroviral drugs interact within the central nervous system (CNS) to shape disease development, progression, and clinical symptoms.
The scientific focus is on discovering and testing "novel genetic paradigms" that explain HAND in treated patients, rather than simply describing clinical outcomes. Applicants are encouraged to use modern, high resolution genetics and genomics tools such as transcriptomics, phenomics, epigenomics, genome wide association studies, next generation sequencing, exome sequencing, and systems biology. The FOA also makes clear that identifying candidate factors is not enough on its own; it encourages validation work using appropriate experimental and translational platforms, including in vitro systems, animal models, and human samples. In practice, this means proposals should be positioned to connect genetic variation or gene regulation patterns to mechanisms in the CNS that plausibly drive inflammation, neuronal injury, viral persistence, drug effects, or other pathways that could explain ongoing neurocognitive dysfunction under HAART.
The mechanism is the NIH R01 research project grant, intended for more mature, hypothesis driven projects with substantial scope. This announcement runs alongside a companion FOA with the same scientific topic using the R21 exploratory/developmental mechanism (MH 11 021), which is generally geared toward earlier stage or higher risk concept testing. For this R01 FOA and the companion announcement together, NIMH set aside 2.0 million dollars in fiscal year 2011 and NINDS set aside 1.0 million dollars, for an estimated total of 3.0 million dollars. Across the effort, NIH anticipated funding about 5 to 7 R01 awards, reflecting a competitive program with a limited number of funded projects.
Eligibility is broad and includes many types of U.S. and non U.S. organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for profit organizations (including small businesses and other for profits), state, county, city or township governments, special district governments, independent school districts, and public housing or Indian housing authorities. The FOA also explicitly includes a wide range of mission focused institutions and community based entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, faith based or community based organizations, U.S. territories or possessions, and foreign organizations or other non domestic entities, as well as tribal governments and tribal organizations (both federally recognized and other than federally recognized, as specified). The announcement states there is no cost sharing or matching requirement.
Administratively, the opportunity was posted July 29, 2010, with an application closing date of January 6, 2011, and it was archived February 6, 2011. The program is administered by the National Institutes of Health, led scientifically by NIMH and NINDS, and it is tied to CFDA numbers 93.242 (Mental Health Research Grants) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The full announcement was provided through the NIH grants guide at the linked RFA page, and NIH Office of Extramural Research support contacts were listed for access or linking issues.
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Viral and Host Genetic Factors Regulating HIV Associated CNS Disease (R01)" and is identified as RFA MH 11 020.
What is the main goal of this FOA?
The FOA supports research aimed at understanding why HIV-1 Associated Neurocognitive Disorders (HAND) continue to affect a large share of people living with HIV even in the era of highly active antiretroviral therapy (HAART), including why more than half of HIV-infected patients may still show signs of neurocognitive impairment despite treatment.
What problem is this opportunity trying to address?
The FOA highlights that clinical studies indicate persistent neurocognitive impairment in many treated patients, and it calls for research into genetic and genomic explanations for this persistence within the central nervous system (CNS).
Which NIH Institutes are leading this opportunity?
The opportunity is administered by the National Institutes of Health (NIH) and led scientifically by the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS).
What research areas or themes does the FOA emphasize?
The FOA emphasizes genetic and genomic reasons for HAND persistence under HAART, with special focus on how viral factors, host factors, and antiretroviral drugs interact within the CNS to influence disease development, progression, and clinical symptoms.
What does the FOA mean by "novel genetic paradigms"?
Based on the FOA description, the emphasis is on discovering and testing new genetic or genomic frameworks that can explain HAND in treated patients, rather than simply reporting or describing clinical outcomes.
Is it enough to identify candidate genes or genetic factors?
No. The FOA indicates that identifying candidate factors alone is not sufficient, and it encourages validation using appropriate experimental and translational platforms.
What kinds of tools and approaches are encouraged?
The FOA encourages modern, high-resolution genetics and genomics approaches, including transcriptomics, phenomics, epigenomics, genome-wide association studies (GWAS), next-generation sequencing, exome sequencing, and systems biology.
What types of validation platforms are mentioned?
The FOA encourages validation work using in vitro systems, animal models, and human samples.
What types of biological mechanisms should proposals aim to connect to genetics or genomics findings?
Proposals are expected to connect genetic variation or gene regulation patterns to plausible CNS mechanisms that could drive outcomes such as inflammation, neuronal injury, viral persistence, drug effects, or other pathways that may explain ongoing neurocognitive dysfunction under HAART.
What grant mechanism is being used?
This opportunity uses the NIH R01 research project grant mechanism, described as intended for more mature, hypothesis-driven projects with substantial scope.
Is there a related or companion funding opportunity?
Yes. The FOA notes a companion announcement on the same scientific topic using the R21 exploratory/developmental mechanism (MH 11 021), which is generally geared toward earlier-stage or higher-risk concept testing.
How much funding was set aside for this effort?
For this R01 FOA and the companion announcement together, NIMH set aside $2.0 million (FY 2011) and NINDS set aside $1.0 million, for an estimated total of $3.0 million.
How many awards did NIH anticipate making?
Across the effort, NIH anticipated funding about 5 to 7 R01 awards, indicating a competitive program with a limited number of funded projects.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations, including (as listed in the FOA summary): public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses); state, county, city, township, and special district governments; independent school districts; and public housing or Indian housing authorities.
Are community-based and mission-focused institutions included in eligibility?
Yes. The FOA explicitly includes mission-focused and community-based entities such as HBCUs, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, and tribal governments and tribal organizations (as specified in the announcement).
Are foreign (non-U.S.) organizations allowed to apply?
Yes. The FOA summary explicitly includes foreign organizations and other non-domestic entities among eligible applicants.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
When was this funding opportunity posted?
The opportunity was posted on July 29, 2010.
What was the application due date?
The application closing date was January 6, 2011.
What does it mean that the opportunity was archived?
The FOA was archived on February 6, 2011, meaning it was no longer active after that date as an open funding opportunity.
What CFDA numbers are associated with this FOA?
The FOA is tied to CFDA 93.242 (Mental Health Research Grants) and CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Where was the full announcement provided?
The full announcement was provided through the NIH grants guide at the linked RFA page referenced in the opportunity description.
Who should be contacted for technical issues accessing the announcement?
The opportunity notes that NIH Office of Extramural Research support contacts were listed for access or linking issues.
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