Opportunity Information: Apply for PA 07 331
Apply for PA 07 331
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Apr 7, 2010 and posted on Mar 15, 2007.
- Applicants must submit their applications by Sep 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Private institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH grant opportunity "Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R21)" (Funding Opportunity Number PA-07-331) is a discretionary federal funding announcement focused on improving what is known about women and about sex- and gender-based differences in drug and alcohol abuse and dependence. In practical terms, the program is meant to push the science beyond one-size-fits-all addiction models by encouraging studies that examine how biological sex factors (such as hormones, reproductive status, and sex-linked biology) and gender-related factors (such as social roles, stress exposure, stigma, and access to care) may shape risk, progression, consequences, and responses to prevention or treatment for substance use disorders. While the announcement is framed broadly, its central goal is to generate findings that help explain why addiction-related patterns and outcomes may differ for women compared with men, and among subgroups of women, so that interventions and services can be better tailored and more effective.
This FOA uses the NIH R21 mechanism, which is designed for exploratory or early-stage projects that can open up new directions, test novel ideas, develop methods, or produce preliminary data that supports later, larger studies. The R21 mechanism typically fits projects that are innovative and focused, rather than long, multi-year definitive trials. The announcement also notes that it runs in parallel with two related opportunities that cover the same scientific scope but different grant mechanisms: PA-07-329 (R01) for larger research projects, and PA-07-330 (R03) for smaller exploratory/developmental projects. Applicants are expected to choose the mechanism that best matches the maturity and scale of their proposed work, with PA-07-331 being the R21 option.
The funding falls under NIH health research programs, specifically connected to CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs). The awarding agency is the National Institutes of Health. As with many NIH announcements, the number of awards and the total funding available are not guaranteed in advance; awards depend on congressional appropriations, NIH priorities, and whether enough high-quality, meritorious applications are submitted in the relevant receipt cycles. The opportunity explicitly states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving the award.
Eligibility is intentionally broad and includes many types of domestic and non-domestic institutions and organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a wide range of governmental bodies such as state, county, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Federally recognized Native American tribal governments and other Native American tribal organizations are eligible. The announcement also clarifies that foreign institutions may apply, eligible federal agencies may apply, and faith-based or community-based organizations may apply, expanding the pool to include organizations that may be closely connected to affected communities and real-world service settings.
From an administrative standpoint, the opportunity was posted on March 15, 2007, with a listed current closing date of September 7, 2010, and multiple receipt dates, meaning NIH accepted applications on several standard submission cycles rather than a single one-time deadline. The archive date is October 7, 2010, indicating the announcement is historical/archived rather than currently open. The full announcement was hosted on the NIH Grants Guide website at the link provided (http://grants.nih.gov/grants/guide/pa-files/PA-07-331.html). For access problems or technical issues with the listing, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PA-07-331 is best understood as an NIH invitation for concise, high-impact exploratory research projects that clarify women-specific issues and sex/gender differences in substance abuse and dependence, with the broader intent of improving prevention, treatment, and public health responses by grounding them in evidence that reflects real biological and social differences rather than assuming uniform addiction pathways across populations.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R21)."
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is PA-07-331.
Which federal agency is offering this grant opportunity?
The awarding agency is the National Institutes of Health (NIH).
What is the main purpose of PA-07-331?
The purpose is to improve what is known about women and about sex- and gender-based differences in drug and alcohol abuse and dependence. The announcement encourages research that examines how biological sex factors and gender-related factors may shape risk, progression, consequences, and responses to prevention or treatment for substance use disorders.
What kinds of differences does the FOA want researchers to study?
The FOA highlights both biological sex factors (for example, hormones, reproductive status, and sex-linked biology) and gender-related factors (for example, social roles, stress exposure, stigma, and access to care) as influences that may contribute to differences in substance use disorder patterns and outcomes.
How does this opportunity aim to improve prevention and treatment?
By generating findings that help explain why addiction-related patterns and outcomes may differ for women compared with men, and among subgroups of women, the FOA aims to support better-tailored and more effective interventions and services.
What grant mechanism does PA-07-331 use?
PA-07-331 uses the NIH R21 mechanism.
What is the NIH R21 mechanism designed for?
The R21 mechanism is designed for exploratory or early-stage projects that can open up new directions, test novel ideas, develop methods, or produce preliminary data that supports later, larger studies.
Is this intended for large, long-term definitive trials?
The announcement indicates the R21 typically fits innovative and focused projects rather than long, multi-year definitive trials.
Are there related opportunities with the same scientific scope but different grant mechanisms?
Yes. The announcement notes two related opportunities covering the same scientific scope: PA-07-329 (R01) for larger research projects and PA-07-330 (R03) for smaller exploratory/developmental projects.
How should an applicant choose between the R21, R01, and R03 options mentioned?
Applicants are expected to choose the mechanism that best matches the maturity and scale of the proposed work, with PA-07-331 being the R21 option.
Which CFDA numbers are associated with this opportunity?
The FOA is connected to CFDA 93.273 (Alcohol Research Programs) and CFDA 93.279 (Drug Abuse and Addiction Research Programs).
Is cost sharing or matching required to apply or receive an award?
No. The opportunity explicitly states there is no cost sharing or matching requirement.
Is the amount of funding or the number of awards guaranteed?
No. The FOA states that the number of awards and total funding available are not guaranteed in advance and depend on factors such as congressional appropriations, NIH priorities, and the number of high-quality, meritorious applications submitted in the relevant receipt cycles.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic institutions and organizations, including higher education institutions, nonprofits, for-profit organizations (including small businesses), and multiple types of governmental bodies.
Can colleges and universities apply?
Yes. Public and private institutions of higher education are listed as eligible applicants.
Can nonprofit organizations apply?
Yes. Eligible applicants include nonprofits, including both 501(c)(3) and non-501(c)(3) entities.
Can for-profit organizations or small businesses apply?
Yes. The eligible applicant types include for-profit organizations, including small businesses and other for-profits.
What types of government entities are eligible?
Eligible governmental bodies include state governments, county governments, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are Native American tribal governments or organizations eligible?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are eligible.
Can foreign institutions apply?
Yes. The announcement clarifies that foreign institutions may apply.
Can federal agencies apply?
Yes. The announcement states that eligible federal agencies may apply.
Can faith-based or community-based organizations apply?
Yes. The announcement specifies that faith-based or community-based organizations may apply.
When was the opportunity posted?
The opportunity was posted on March 15, 2007.
What was the listed closing date for this announcement?
The listed current closing date is September 7, 2010.
Did this FOA have multiple submission deadlines?
Yes. The announcement notes multiple receipt dates, meaning NIH accepted applications on several standard submission cycles rather than using a single one-time deadline.
Is this opportunity still open?
No. The archive date is October 7, 2010, indicating the announcement is historical/archived rather than currently open.
Where can the full original announcement be found?
The full announcement was hosted on the NIH Grants Guide website at: http://grants.nih.gov/grants/guide/pa-files/PA-07-331.html
Who should be contacted for access problems or technical issues with the listing?
For access problems or technical issues with the listing, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
In plain terms, what kind of projects was NIH trying to encourage under PA-07-331?
Concise, high-impact exploratory studies that push beyond one-size-fits-all addiction models by clarifying women-specific issues and sex/gender differences in substance abuse and dependence, with the broader goal of improving prevention, treatment, and public health responses.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 331) also looked into and applied for these:
| Funding Opportunity |
|---|
| Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R03) Apply for PA 07 330 Funding Number: PA 07 330 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Medications Development for the Treatment of Amphetamine and Amphetamine Like Related Disorders (R01) Apply for PA 07 333 Funding Number: PA 07 333 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Medications Development for the Treatment of Amphetamine and Amphetamine Like Related Disorders (R21) Apply for PA 07 334 Funding Number: PA 07 334 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development of Animal Models and Related Biological Materials For Research (R21) Apply for PA 07 336 Funding Number: PA 07 336 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| HIV Treatment Adherence Research (R01) Apply for PA 07 338 Funding Number: PA 07 338 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| HIV Treatment Adherence Research (R03) Apply for PA 07 339 Funding Number: PA 07 339 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| HIV Treatment Adherence Research (R21) Apply for PA 07 340 Funding Number: PA 07 340 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Developing And Improving Institutional Animal Resources (G20) Apply for PAR 07 342 Funding Number: PAR 07 342 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| AIDS Science Track Award for Research Transition (R03) Apply for PA 07 349 Funding Number: PA 07 349 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Bioengineering and Obesity (R01) Apply for PA 07 354 Funding Number: PA 07 354 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Improving Heart Failure Disease Management (R01) Apply for PA 07 355 Funding Number: PA 07 355 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Clinical Cancer Therapy and Prevention Research (R01) Apply for PA 07 356 Funding Number: PA 07 356 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exploratory Cancer Prevention Studies Involving Molecular Targets for Bioactive Food Components (R21) Apply for PA 07 362 Funding Number: PA 07 362 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Medications Development for the Treatment of Cannabis Related Disorders (R01) Apply for PA 07 365 Funding Number: PA 07 365 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Medications Development for the Treatment of Cannabis Related Disorders (R21) Apply for PA 07 366 Funding Number: PA 07 366 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Omics and Variable Responses to CAM Secondary Analysis of CAM Clinical Trials (R01) Apply for PAR 07 377 Funding Number: PAR 07 377 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Omics and Variable Responses to CAM Secondary Analysis of CAM Clinical Trials (R21) Apply for PAR 07 378 Funding Number: PAR 07 378 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Nutrition and Alcohol Related Health Outcomes (R01) Apply for PA 07 403 Funding Number: PA 07 403 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Nutrition and Alcohol Related Health Outcomes (R03) Apply for PA 07 404 Funding Number: PA 07 404 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Genetic Epidemiology of Substance Use Disorders(R01) Apply for PA 07 413 Funding Number: PA 07 413 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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