Opportunity Information: Apply for PA 06 377
Apply for PA 06 377
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Women s Mental Health in Pregnancy and the Postpartum Period (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Apr 28, 2006.
- Applicants must submit their applications by May 7, 2009 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts State governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Special district governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification).
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The National Institutes of Health (NIH) grant opportunity PA-06-377, titled "Women s Mental Health in Pregnancy and the Postpartum Period (R21)," supports exploratory and early-stage research focused on mental health conditions that occur during pregnancy and after childbirth. It uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is designed for innovative projects that may be at a preliminary stage but have the potential to open up promising new directions. In practice, this FOA is aimed at helping researchers test new ideas, generate pilot data, develop new methods, or explore emerging hypotheses related to perinatal mental health within a shorter project window.
Scientifically, the announcement targets both perinatal non-psychotic mood disorders (such as depression and anxiety conditions occurring during pregnancy or postpartum) and psychotic disorders (including postpartum psychosis and related severe conditions). NIH highlights four broad research areas. First, it encourages studies on clinical course, epidemiology, and risk factors, meaning projects that clarify how these disorders begin, change over time, and differ across populations, as well as what biological, psychological, social, and environmental factors increase or reduce risk. Second, it calls for basic and clinical neuroscience research, which can include work on brain, hormonal, immune, genetic, and neurobiological mechanisms that may underlie vulnerability or resilience during the perinatal period. Third, it supports intervention research, which can range from developing or pilot-testing preventive approaches to evaluating treatments adapted for pregnancy and postpartum populations, including considerations of safety, feasibility, and acceptability. Fourth, it seeks services research, emphasizing real-world care delivery issues such as screening, referral pathways, access barriers, implementation strategies, and models of integrated care across obstetric, primary care, and mental health settings.
A notable emphasis in the FOA is the relationship between substance use and perinatal mental health. NIH explicitly encourages studies that examine how current or lifetime drug abuse affects the onset, severity, and course of mental disorders during pregnancy and postpartum. This includes attention to whether an individual is in treatment, what kind of treatment they receive, and how comorbid conditions (for example, co-occurring psychiatric diagnoses or medical complications) interact with substance use and perinatal mental health outcomes. This focus reflects the complexity of perinatal mental health, where overlapping risk factors can shape both maternal outcomes and family functioning.
In terms of structure and limits, the R21 projects under this announcement may last no more than two years. The budget cap is $275,000 in direct costs across the two-year period, with an additional constraint that no more than $200,000 in direct costs may be requested in any single year. NIH notes that the number of awards and total dollars ultimately committed depend on the number of applications received and their scientific merit, proposed duration, and requested costs. The FOA also runs in parallel with a companion announcement of the same scientific scope that uses the R01 mechanism (PA-06-376), which is typically more appropriate for larger or more mature research programs; the R21 version is positioned for smaller, faster, exploratory efforts.
Eligibility is broad and includes for-profit and non-profit organizations, public or private institutions such as universities, colleges, hospitals, and laboratories, and various government entities at the state and local level. Federal agencies may also apply, and the opportunity is open to domestic and foreign institutions. The FOA also explicitly welcomes applications from faith-based or community-based organizations and from Tribal governments and Tribal organizations, including both federally recognized and other-than-federally recognized entities, reflecting an intent to support research that can reach diverse communities and care settings.
For principal investigators, NIH keeps eligibility open: any individual with the expertise and resources to carry out the proposed work may serve as PD/PI, and the agency reiterates its longstanding encouragement for applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities. Applicants may submit more than one application as long as each proposal is scientifically distinct, which allows teams to pursue different lines of inquiry under the same overall perinatal mental health theme.
Administratively, the FOA is a discretionary grant opportunity in the areas of health, education, and social services, and it lists CFDA program areas tied to healthcare quality and outcomes, mental health research, drug abuse and addiction research, and child health and human development. There is no cost-sharing or matching requirement. The announcement was originally posted April 28, 2006, with multiple receipt dates and a final listed closing date of May 7, 2009, after which it was archived June 7, 2009. The full announcement and detailed instructions were provided through the NIH Grants Guide link (PA-06-377), with NIH Office of Extramural Research (OER) contact support for access or technical issues.
FAQs: NIH PA-06-377 - Women's Mental Health in Pregnancy and the Postpartum Period (R21)
What is NIH PA-06-377?
PA-06-377 is a National Institutes of Health (NIH) funding opportunity announcement titled "Women's Mental Health in Pregnancy and the Postpartum Period (R21)." It supports exploratory and early-stage research on mental health conditions that occur during pregnancy and after childbirth (the perinatal period).
What type of grant mechanism does this opportunity use?
This announcement uses the NIH Exploratory/Developmental Research Grant (R21) mechanism. The R21 is intended for innovative projects that may be preliminary but can open promising new research directions.
What is the main purpose of the R21 under this FOA?
The R21 under PA-06-377 is aimed at shorter, exploratory efforts such as testing new ideas, generating pilot data, developing new methods, or exploring emerging hypotheses related to perinatal mental health.
What mental health conditions are in scope?
The FOA targets both perinatal non-psychotic mood disorders (for example, depression and anxiety during pregnancy or postpartum) and psychotic disorders (including postpartum psychosis and related severe conditions).
What research areas does NIH emphasize in this announcement?
NIH highlights four broad research areas: (1) clinical course, epidemiology, and risk factors; (2) basic and clinical neuroscience; (3) intervention research; and (4) services research focused on real-world care delivery.
What kinds of studies fit under "clinical course, epidemiology, and risk factors"?
This category includes studies that examine how perinatal mental disorders begin and change over time, how they vary across populations, and what biological, psychological, social, or environmental factors may increase risk or provide protection.
What does "basic and clinical neuroscience" mean in the context of this FOA?
In this FOA, neuroscience research can include studies of brain, hormonal, immune, genetic, and other neurobiological mechanisms that may contribute to vulnerability or resilience during pregnancy and the postpartum period.
What types of intervention research are encouraged?
The FOA supports developing or pilot-testing prevention approaches and evaluating treatments adapted for pregnant and postpartum populations. It also points to practical considerations such as safety, feasibility, and acceptability.
What is meant by "services research" here?
Services research in this announcement focuses on real-world delivery of care, including screening approaches, referral pathways, barriers to access, implementation strategies, and models that integrate obstetric, primary care, and mental health services.
Is there a special emphasis on substance use?
Yes. NIH explicitly encourages studies examining how current or lifetime drug abuse affects the onset, severity, and course of mental disorders during pregnancy and postpartum.
What substance use-related factors does the FOA encourage applicants to consider?
The announcement encourages attention to whether an individual is in treatment, what kind of treatment they receive, and how comorbid conditions (such as additional psychiatric diagnoses or medical complications) interact with substance use and perinatal mental health outcomes.
How long can an R21 project last under this opportunity?
Projects may last no more than two years.
What is the budget limit for PA-06-377 (R21)?
The budget cap is $275,000 in direct costs total across the two-year project period, with an additional constraint of no more than $200,000 in direct costs in any single year.
How many awards will NIH make under this FOA?
The FOA states that the number of awards and total dollars committed depend on the number of applications received and factors such as scientific merit, proposed project duration, and requested costs.
Is there a related funding opportunity for larger studies?
Yes. The FOA runs in parallel with a companion announcement using the R01 mechanism (PA-06-376) with the same scientific scope. The R01 is generally more suitable for larger or more mature research programs, while the R21 is positioned for smaller, faster, exploratory efforts.
What organizations are eligible to apply?
Eligibility is broad and includes for-profit and non-profit organizations; public or private institutions such as universities, colleges, hospitals, and laboratories; and state and local government entities. Federal agencies may also apply, and both domestic and foreign institutions are eligible.
Are faith-based and community-based organizations eligible?
Yes. The FOA explicitly welcomes applications from faith-based or community-based organizations.
Are Tribal governments and Tribal organizations eligible?
Yes. Tribal governments and Tribal organizations are eligible, including both federally recognized and other-than-federally recognized entities.
Who can serve as the Principal Investigator (PD/PI)?
Any individual with the expertise and resources to carry out the proposed work may serve as PD/PI under this FOA.
Does NIH encourage applications from underrepresented groups?
Yes. NIH reiterates its encouragement for applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities.
Can an applicant submit more than one application?
Yes. Applicants may submit more than one application as long as each proposal is scientifically distinct.
Are cost sharing or matching funds required?
No. The FOA states there is no cost-sharing or matching requirement.
What program areas (CFDA) are associated with this FOA?
The announcement lists CFDA program areas tied to healthcare quality and outcomes, mental health research, drug abuse and addiction research, and child health and human development.
When was this opportunity posted and when did it close?
The announcement was originally posted on April 28, 2006. It listed multiple receipt dates and a final closing date of May 7, 2009. It was archived on June 7, 2009.
Where were the full instructions and announcement details provided?
The full announcement and detailed instructions were provided through the NIH Grants Guide link for PA-06-377.
Who is listed for support if there are access or technical issues?
The FOA notes NIH Office of Extramural Research (OER) contact support for access or technical issues.
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