Opportunity Information: Apply for RFA DK 14 003
Apply for RFA DK 14 003
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Apr 25, 2014 and posted on Apr 25, 2014.
- Applicants must submit their applications by Jul 18, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities County governments Native American tribal governments (Federally recognized) Special district governments City or township governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (U01)" (Funding Opportunity Number RFA-DK-14-003) is an NIH discretionary grant offered as a cooperative agreement (U01) focused on advancing the understanding of the genetic basis of type 2 diabetes. It is part of the Accelerating Medicines Partnership framework and supports the AMP T2D GENES consortium, which is intended to build directly on and expand prior work conducted under the earlier T2D GENES consortium. The core scientific purpose is to more precisely characterize genetic variation within human genomic regions that have already been flagged as potentially associated with type 2 diabetes risk, and then to move beyond association signals by carrying out functional follow-up studies on selected variants to determine how, where, and why they influence disease biology. In practice, this means taking regions identified through prior human genetic studies, refining the list of plausible causal variants, and performing experimental or computational work to understand the biological mechanisms linking those variants to type 2 diabetes-relevant pathways, cell types, or phenotypes.
Because this is a cooperative agreement rather than a standard research project grant, awardees are expected to operate as part of a coordinated consortium with substantial scientific interaction and involvement across sites, typically including shared milestones, common data and sample standards, harmonized analysis plans, and regular coordination with NIH program staff and other consortium members. A key operational detail in this announcement is that the consortiums data coordinating center is not being funded through this FOA; instead, the coordinating center is being solicited under a separate companion FOA. This setup signals that funded research teams under RFA-DK-14-003 would be expected to interface with an external coordinating hub for data submission, quality control, integration, and dissemination, rather than building independent, siloed infrastructure.
The FOA falls under the NIH program for Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) and is categorized under the activity area of Food and Nutrition Health. The total estimated funding level listed is $3,000,000, with an award ceiling of $300,000, and there is no cost sharing or matching requirement. The opportunity was posted on April 25, 2014, with an original and current closing date of July 18, 2014, and an archive date of August 18, 2014, indicating it is a historical, time-limited solicitation rather than an ongoing open call.
Eligibility is broad and includes a wide range of domestic and non-domestic entities. Eligible applicants include state and local governments (such as city or township governments, county governments, special district governments), public housing authorities/Indian housing authorities, and independent school districts. Both nonprofit and for-profit organizations are eligible, including nonprofits with 501(c)(3) status and those without 501(c)(3) status, as well as small businesses and for-profit organizations other than small businesses. Institutions of higher education are eligible in both public/state-controlled and private categories. The announcement also explicitly allows applications from federally recognized Native American tribal governments and non-federally recognized tribal organizations, and it highlights eligibility for a variety of mission-serving institutions and community-based groups, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations. Importantly, foreign organizations and foreign institutions are eligible to apply, and non-U.S. components of U.S. organizations may participate; foreign components are allowed consistent with the NIH Grants Policy Statement.
Overall, this FOA is designed to push type 2 diabetes genetics from discovery toward biological interpretation by organizing multiple awardees into a consortium that systematically interrogates putative T2D-associated genomic regions and performs functional studies on prioritized variants. The expectation is that participants will contribute data and analyses in a coordinated way, aligned with consortium governance and the separately funded data coordinating center. For applicants, the opportunity is best viewed as a collaborative, milestone-driven effort where scientific value comes from standardization, shared resources, and collective generation of genetic and functional evidence that can clarify disease mechanisms and ultimately inform therapeutic target discovery.
For full details, the announcement points to the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-003.html, and it lists NIH OER support contacts (FBOWebmaster@OD.NIH.GOV) for access or linking issues.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the NIH funding announcement titled "Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (U01)" with Funding Opportunity Number RFA-DK-14-003. It is a discretionary NIH grant mechanism offered as a cooperative agreement (U01).
What is the main scientific goal of RFA-DK-14-003?
The core goal is to advance understanding of the genetic basis of type 2 diabetes by more precisely characterizing genetic variation in human genomic regions already flagged as potentially associated with type 2 diabetes risk, and then performing functional follow-up studies on selected variants to determine how, where, and why they influence disease biology.
What does "moving beyond association signals" mean in this FOA?
Based on the description provided, it means taking genomic regions identified through prior human genetic studies, narrowing down the list of plausible causal variants, and then conducting experimental or computational studies to understand the biological mechanisms linking those variants to type 2 diabetes-relevant pathways, cell types, or phenotypes.
What consortium is supported through this FOA?
This FOA supports the AMP T2D GENES consortium. The consortium is intended to build directly on and expand prior work conducted under an earlier T2D GENES consortium.
What type of award mechanism is being used, and why does it matter?
The mechanism is a cooperative agreement (U01), not a standard research project grant. That matters because awardees are expected to operate as part of a coordinated consortium with substantial scientific interaction and involvement across sites, including shared milestones, common data and sample standards, harmonized analysis plans, and regular coordination with NIH program staff and other consortium members.
How is coordination and data management handled for the consortium?
A key operational detail is that the consortium's data coordinating center is not funded through this FOA. Instead, the coordinating center is being solicited under a separate companion FOA. Funded teams under RFA-DK-14-003 are expected to interface with an external coordinating hub for data submission, quality control, integration, and dissemination rather than building independent, siloed infrastructure.
Is the data coordinating center funded as part of this announcement?
No. The data coordinating center is not being funded through RFA-DK-14-003; it is being solicited under a separate companion FOA.
Which NIH program area is associated with this FOA?
The FOA falls under the NIH program for Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) and is categorized under the activity area of Food and Nutrition Health.
How much funding is available under this opportunity?
The total estimated funding level listed is $3,000,000.
What is the maximum award amount (award ceiling)?
The award ceiling listed is $300,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
When was the opportunity posted, and what were the key dates?
The opportunity was posted on April 25, 2014. The original and current closing date is July 18, 2014. The archive date is August 18, 2014.
Is this an active funding opportunity?
Based on the listed closing date (July 18, 2014) and archive date (August 18, 2014), this appears to be a historical, time-limited solicitation rather than an ongoing open call.
Who is eligible to apply?
Eligibility is broad and includes domestic and non-domestic entities. Eligible applicants include state and local governments (including city or township governments, county governments, and special district governments), public housing authorities/Indian housing authorities, and independent school districts. Nonprofit and for-profit organizations are eligible, including 501(c)(3) nonprofits and nonprofits without 501(c)(3) status, as well as small businesses and for-profit organizations other than small businesses. Institutions of higher education (public/state-controlled and private) are also eligible.
Are tribal governments and tribal organizations eligible?
Yes. The announcement explicitly allows applications from federally recognized Native American tribal governments and non-federally recognized tribal organizations.
Are mission-serving and community-based organizations eligible?
Yes. The FOA highlights eligibility for a variety of mission-serving institutions and community-based groups, including HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations.
Are foreign organizations eligible to apply?
Yes. Foreign organizations and foreign institutions are eligible to apply, and non-U.S. components of U.S. organizations may participate. Foreign components are allowed consistent with the NIH Grants Policy Statement.
What kind of work is this FOA designed to support?
It is designed to push type 2 diabetes genetics from discovery toward biological interpretation by organizing multiple awardees into a consortium that systematically interrogates putative type 2 diabetes-associated genomic regions and performs functional studies on prioritized variants.
What operational expectations should applicants anticipate under a U01 consortium model?
Applicants should anticipate coordinated, milestone-driven work with substantial cross-site interaction, including shared milestones, common data and sample standards, harmonized analysis plans, and regular coordination with NIH program staff and other consortium members, plus integration with a separately funded data coordinating center.
Where can applicants find the full official announcement?
The FOA points to the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-003.html
Who can be contacted for access or linking issues related to the NIH posting?
The announcement lists NIH OER support contacts for access or linking issues at: FBOWebmaster@OD.NIH.GOV
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| Limited Competition for the Data Coordinating Center of Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (U01) Apply for RFA DK 14 503 Funding Number: RFA DK 14 503 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $2,500,000 |
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| Diabetes Impact Award Closed Loop Technologies Clinical, Physiological and Behavioral Approaches to Improve Type 1 Diabetes Outcomes (DP3) Apply for RFA DK 14 014 Funding Number: RFA DK 14 014 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Diabetes Impact Award Closed Loop Technologies Development and Integration of Novel Components for an Automated Artificial Pancreas System (DP3) Apply for RFA DK 14 015 Funding Number: RFA DK 14 015 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Nutrition Obesity Research Centers (NORCs) (P30) Apply for RFA DK 14 002 Funding Number: RFA DK 14 002 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Silvio O. Conte Digestive Diseases Research Core Centers (P30) Apply for RFA DK 14 012 Funding Number: RFA DK 14 012 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Increasing the Quality and Efficiency of Clinical Trials (R18) Apply for RFA FD 14 017 Funding Number: RFA FD 14 017 Agency: Food Drug Administration Category: Food and Nutrition Health Funding Amount: $7,500,000 |
| U.S. India Bilateral Collaborative Research Partnerships (CRP) on Diabetes Research (R21) Apply for RFA DK 14 006 Funding Number: RFA DK 14 006 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $275,000 |
| Polycystic Kidney Disease (PKD) Research and Translation Core Centers (P30) Apply for RFA DK 14 013 Funding Number: RFA DK 14 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Research Using Biosamples From Selected Type 1 Diabetes Clinical Studies (DP3) Apply for PAR 14 257 Funding Number: PAR 14 257 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $4,000,000 |
| Research Using Subjects From Selected Type 1 Diabetes Clinical Studies (Living Biobank) (DP3) Apply for PAR 14 258 Funding Number: PAR 14 258 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $7,000,000 |
| Chronic Kidney Disease Biomarkers Consortium (CKD BioCon) (U01) Apply for RFA DK 14 011 Funding Number: RFA DK 14 011 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $450,000 |
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| NIDDK Mentored Research Scientist Development Award (K01) Apply for PAR 14 266 Funding Number: PAR 14 266 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4) Apply for RFA DK 14 505 Funding Number: RFA DK 14 505 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $20,000,000 |
| NIAID SBIR Technology Transfer Direct Phase II (SBIR TT) (R44) Apply for RFA AI 14 049 Funding Number: RFA AI 14 049 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $1,000,000 |
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| Limited Competition for the Continuation of the Adult Acute Liver Failure Study Group (U01) Apply for RFA DK 14 504 Funding Number: RFA DK 14 504 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $3,500,000 |
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