Opportunity Information: Apply for RFA DK 14 503
Apply for RFA DK 14 503
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Limited Competition for the Data Coordinating Center of Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Apr 25, 2014 and posted on Apr 25, 2014.
- Applicants must submit their applications by Jul 18, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $2,500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Only the current awardee serving as the Data Coordinating Center of Multiethnic Study of Type 2 Diabetes Genes consortium (T2D GENES) is eligible to apply for this Funding Opportunity Announcement. Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
This grant opportunity (RFA-DK-14-503) is a limited, one-time NIH cooperative agreement (U01) meant to keep the Data Coordinating Center (DCC) for the Accelerating Medicines Partnership (AMP) in Type 2 Diabetes running and expanding for up to five years, as long as progress is satisfactory. The DCC sits at the center of the AMP T2D GENES consortium, which is a multi-site effort focused on identifying and understanding genetic variants in human genomic regions believed to be linked to type 2 diabetes, and then supporting follow-up functional studies to learn how specific variants may influence disease biology. In practical terms, the FOA is designed to ensure the consortium has a stable hub that can manage data and coordination needs while multiple participating research sites generate new datasets and analyses under a companion FOA.
The core purpose of the award is to fund the DCC to continue building and improving the consortiums web portal and to handle end-to-end data responsibilities. That includes depositing data, aggregating it across sites, processing it into usable forms, and making it accessible in ways that support both the AMP T2D GENES investigators and the broader T2D GENES research community. The DCC is also expected to provide the administrative and operational infrastructure for the NIDDK-funded consortium: coordinating activities across centers, supporting consistent workflows, helping manage timelines and deliverables, and generally keeping the consortium functioning as a coherent program rather than a set of disconnected projects. The announcement emphasizes that the DCC should build on and expand what was previously developed under the T2D GENES consortium, rather than starting from scratch.
From a funding and structure standpoint, this is a discretionary award using the cooperative agreement mechanism, which typically means NIH staff will have substantial involvement in oversight and coordination compared to a standard grant. The opportunity anticipates a single award (Expected Awards: 1), with an estimated total funding amount of $2.5 million and an award ceiling of $2.5 million, and it does not require cost sharing or matching. The activity category is listed under health (with a food and nutrition/health label in the record), and it falls under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), aligning it with NIDDKs research mission.
Eligibility is extremely restricted. Only the current awardee serving as the Data Coordinating Center for the Multiethnic Study of Type 2 Diabetes Genes consortium (T2D GENES) is allowed to apply. Foreign institutions cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. In other words, the FOA is essentially a continuation/transition vehicle intended for the incumbent DCC to carry forward the coordination role into the AMP T2D GENES phase.
Key dates reflect that this was posted on April 25, 2014, with an original (and final) closing date of July 18, 2014, and an archive date of August 18, 2014. The administering agency is the National Institutes of Health (with the program aligned to NIDDK), and the full announcement was made available through the NIH Grants Guide. Contact details in the listing point to the NIH Office of Extramural Research (OER) webmaster for technical issues accessing or linking to the announcement, indicating the public notice is primarily informational and that scientific/programmatic engagement would occur through the cooperative agreement structure once awarded.
In summary, this FOA is best understood as a targeted, limited competition to keep a specialized, incumbent data coordinating center in place so the AMP T2D GENES consortium can reliably collect, standardize, process, share, and manage complex genetics and functional follow-up data at scale, supported by a dedicated portal and coordinated administrative infrastructure, for up to five years.
Frequently Asked Questions (FAQs)
What is the grant opportunity RFA-DK-14-503?
RFA-DK-14-503 is a limited, one-time NIH funding opportunity that uses a cooperative agreement mechanism (U01) to support the continued operation and expansion of the Data Coordinating Center (DCC) for the Accelerating Medicines Partnership (AMP) Type 2 Diabetes effort (AMP T2D GENES). The intent is to keep the consortiums central coordinating and data hub running while multiple research sites generate new datasets and analyses under a companion funding opportunity.
What is the purpose of this award?
The core purpose is to fund the DCC to continue building and improving the T2D GENES consortium web portal and to provide end-to-end data coordination services. This includes data deposition, aggregation across sites, processing into usable formats, and making the data accessible to AMP T2D GENES investigators and the broader T2D GENES research community. The DCC is also expected to provide administrative and operational infrastructure that helps the consortium function as a coordinated program.
What does the DCC do for the AMP T2D GENES consortium?
Based on the announcement description, the DCC serves as the central hub responsible for both data and coordination needs. Responsibilities include supporting consistent workflows across participating sites, coordinating activities across centers, helping manage timelines and deliverables, and maintaining the infrastructure needed for the consortium to operate coherently rather than as disconnected projects.
What kinds of data responsibilities are included?
The opportunity describes end-to-end data responsibilities, including depositing data, aggregating data across consortium sites, processing data into usable forms, and enabling access in ways that support consortium investigators and the broader research community aligned with T2D GENES.
Is this opportunity meant to create a new DCC or continue an existing one?
It is explicitly designed to continue and expand an existing DCC capability. The announcement emphasizes building on and expanding what was previously developed under the T2D GENES consortium rather than starting from scratch.
What is the relationship between AMP T2D GENES and the T2D GENES consortium?
The DCC supported by this opportunity sits at the center of the AMP T2D GENES consortium. The work is described in the context of the broader T2D GENES effort focused on identifying and understanding genetic variants in regions believed to be linked to type 2 diabetes and supporting follow-up functional studies to understand how specific variants may influence disease biology.
What funding mechanism is used and what does it imply?
The award uses the NIH cooperative agreement mechanism (U01). As described in the listing, cooperative agreements typically involve substantial NIH staff involvement in oversight and coordination compared to a standard grant mechanism.
How many awards are expected under this FOA?
The opportunity anticipates a single award (Expected Awards: 1).
What is the estimated total funding and the award ceiling?
The estimated total funding amount is $2.5 million, and the award ceiling is also $2.5 million (as listed in the opportunity summary).
Is cost sharing or matching required?
No. The listing states that cost sharing or matching is not required.
How long can the project be supported?
The opportunity indicates support for up to five years, contingent on satisfactory progress.
Who is eligible to apply?
Eligibility is extremely restricted. Only the current awardee serving as the Data Coordinating Center for the Multiethnic Study of Type 2 Diabetes Genes consortium (T2D GENES) is eligible to apply under this FOA.
Are foreign institutions eligible to apply?
No. Foreign institutions cannot apply under this opportunity.
Are non-U.S. components of U.S. organizations eligible?
No. The listing indicates that non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this FOA?
No. The listing states that foreign components (as defined by NIH policy) are not allowed.
Which NIH institute or program area is associated with this opportunity?
The administering agency is the National Institutes of Health (NIH), and the opportunity is aligned with NIDDK (the National Institute of Diabetes and Digestive and Kidney Diseases) as indicated by the CFDA program alignment and description.
What CFDA program is associated with this opportunity?
The opportunity is listed under CFDA 93.847, which is Diabetes, Digestive, and Kidney Diseases Extramural Research.
What is the activity category or area of focus?
The listing places the activity category under health (with a food and nutrition/health label in the record) and ties it to type 2 diabetes genetics and related functional follow-up studies supported by consortium-scale data coordination.
When was this opportunity posted and when did it close?
It was posted on April 25, 2014. The original and final closing date was July 18, 2014.
Is this funding opportunity still active?
No. The archive date is August 18, 2014, indicating it has been archived.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide, as referenced in the listing.
What is the DCC expected to build or maintain?
The DCC is expected to continue building and improving the consortiums web portal, while also maintaining the broader administrative, operational, and data-management infrastructure needed to support consortium-wide work.
Does the FOA mention how the DCC interacts with other research sites?
Yes. The FOA frames the DCC as the stable hub that manages data and coordination needs while multiple participating research sites generate new datasets and analyses, including work conducted under a companion funding opportunity.
Who is listed as the contact for technical issues with the announcement posting?
The contact details in the listing point to the NIH Office of Extramural Research (OER) webmaster for technical issues accessing or linking to the announcement.
Is this a broad competition open to many applicants?
No. The FOA is best understood as a targeted, limited competition intended for the incumbent DCC to carry forward the coordination role into the AMP T2D GENES phase.
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