Opportunity Information: Apply for PA 16 096
Apply for PA 16 096
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Accelerating Research on Intervertebral Disc (ARID) (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846.
- This funding opportunity was created on Feb 11, 2016 and posted on Feb 11, 2016.
- Applicants must submit their applications by Feb 16, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Accelerating Research on Intervertebral Disc (ARID) (R21) funding opportunity (PA 16-096) is a discretionary NIH grant program administered by the U.S. Department of Health and Human Services through the National Institutes of Health (NIH), specifically NIH11, with scientific interest led by NIAMS. It uses the R21 exploratory/developmental grant mechanism, which is generally meant to support early-stage, high-impact ideas, pilot studies, and proof-of-concept work that can open up new research directions rather than fund large, long-term projects.
The main goal of this FOA is to speed up basic research on the biology of the intervertebral disc. The program is centered on building fundamental understanding of how the disc functions at the cellular and molecular levels and on encouraging studies that can clarify the mechanisms and contributors to disc degeneration. NIAMS explicitly invites investigators across multiple disciplines, including cell biology, bioengineering, and orthopaedic research, and it welcomes either single-investigator projects or collaborative, team-based approaches. The announcement emphasizes applications that either (1) accelerate understanding of basic disc biology or (2) develop new directions for investigating factors that drive degenerative changes, reflecting an interest in innovative concepts, new tools, and fresh mechanistic hypotheses.
From an eligibility standpoint, the FOA is broadly open to many types of U.S.-based applicant organizations. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where specified); for-profit organizations (other than small businesses); small businesses; and additional entities as allowed under NIH policy and any clarification in the FOA text. This wide eligibility is meant to encourage participation from universities, research institutes, clinical and translational groups, engineering teams, and industry partners capable of contributing novel methods or platforms.
Administratively, the FOA falls under the NIH health research activity category (CFDA 93.846). The award ceiling listed is $200,000, indicating that the program is designed for relatively small, exploratory budgets consistent with the R21 mechanism. The opportunity was created and posted on February 11, 2016, and the closing date shown in the provided record is February 16, 2019. While the listing does not specify the expected number of awards in the supplied fields, the emphasis is clearly on catalyzing new lines of investigation rather than supporting a high volume of large projects.
In practical terms, this opportunity is a good fit for researchers proposing innovative, early-stage studies such as identifying and characterizing key biological pathways in disc cells, developing or refining model systems that better capture disc structure and function, testing new measurement approaches or bioengineering tools relevant to disc biology, or generating preliminary data on biological and mechanical factors that contribute to degeneration. The overall intent is to help the field move faster toward a stronger foundational understanding of intervertebral disc biology and the drivers of degeneration, setting the stage for future, more extensive research efforts.
Frequently Asked Questions (FAQs): Accelerating Research on Intervertebral Disc (ARID) (R21) - PA 16-096
What is the ARID (R21) funding opportunity?
The Accelerating Research on Intervertebral Disc (ARID) (R21) funding opportunity (PA 16-096) is a discretionary NIH grant program intended to speed up basic research on the biology of the intervertebral disc. It uses the NIH R21 exploratory/developmental mechanism, which supports early-stage, high-impact concepts, pilot studies, and proof-of-concept work rather than large, long-term projects.
Which federal agency administers this opportunity?
This program is administered by the U.S. Department of Health and Human Services through the National Institutes of Health (NIH). Scientific interest for this FOA is led by NIAMS.
What is the primary goal of this FOA?
The main goal is to accelerate basic research on intervertebral disc biology by building foundational understanding of disc function at the cellular and molecular levels and encouraging studies that clarify mechanisms and contributors to disc degeneration.
What types of research does the FOA emphasize?
The announcement emphasizes applications that either (1) accelerate understanding of basic disc biology or (2) develop new directions for investigating factors that drive degenerative changes. This reflects an interest in innovative concepts, new tools, and fresh mechanistic hypotheses.
Is this funding intended for large, long-term projects?
No. Because it uses the R21 exploratory/developmental mechanism, it is designed to support early-stage, exploratory, and proof-of-concept research rather than large, long-term efforts.
What kinds of projects are a good fit for this opportunity?
Good fits include innovative early-stage studies such as identifying and characterizing key biological pathways in disc cells, developing or refining model systems that better capture disc structure and function, testing new measurement approaches or bioengineering tools relevant to disc biology, or generating preliminary data on biological and mechanical factors that contribute to degeneration.
Which scientific disciplines are encouraged to apply?
NIAMS explicitly invites investigators across multiple disciplines, including cell biology, bioengineering, and orthopaedic research.
Are collaborative or team-based projects allowed?
Yes. The FOA welcomes either single-investigator projects or collaborative, team-based approaches.
Who is eligible to apply?
Eligibility is broadly open to many types of U.S.-based applicant organizations, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where specified); for-profit organizations (other than small businesses); small businesses; and additional entities as allowed under NIH policy and any clarification in the FOA text.
Can for-profit organizations apply?
Yes. The eligibility description includes for-profit organizations (other than small businesses) and also includes small businesses.
Can universities and research institutes apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education, which covers many universities and academic research environments.
Does the FOA encourage participation beyond traditional biomedical labs?
Yes. The broad eligibility is intended to encourage participation from universities, research institutes, clinical and translational groups, engineering teams, and industry partners capable of contributing novel methods or platforms.
What is the NIH mechanism used for this opportunity?
This FOA uses the R21 exploratory/developmental grant mechanism.
What is the funding cap (award ceiling) for this opportunity?
The award ceiling listed is $200,000, consistent with relatively small, exploratory budgets aligned with the R21 mechanism.
What is the CFDA number (health research activity category) for this opportunity?
The FOA is listed under the NIH health research activity category CFDA 93.846.
When was this opportunity created and posted?
The opportunity was created and posted on February 11, 2016.
What closing date is shown for this opportunity in the provided record?
The closing date shown in the provided record is February 16, 2019.
How many awards will be made?
The provided fields do not specify the expected number of awards. The emphasis described is on catalyzing new lines of investigation rather than supporting a high volume of large projects.
What research outcomes is this FOA trying to enable?
The overall intent is to help the field move faster toward a stronger foundational understanding of intervertebral disc biology and the drivers of degeneration, helping position successful ideas and preliminary findings for future, more extensive research efforts.
Is the FOA focused on basic research or clinical trials?
Based on the information provided, the FOA is centered on basic research into intervertebral disc biology and mechanisms of degeneration, with an emphasis on cellular and molecular understanding and exploratory, proof-of-concept studies.
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