Opportunity Information: Apply for W81XWH 16 BMFRP IDA
Apply for W81XWH 16 BMFRP IDA
- The DOD-AMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "Bone Marrow Failure Idea Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Feb 11, 2016 and posted on Feb 11, 2016.
- Applicants must submit their applications by Jul 13, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Bone Marrow Failure (BMF) Idea Development Award, offered through the Department of Defense Bone Marrow Failure Research Program (BMFRP), is designed to push the field toward the program's broader mission of understanding and curing bone marrow failure syndromes. The emphasis is on genuinely new and creative research directions rather than incremental next steps. Projects are expected to be built around a clear, testable hypothesis supported by a strong scientific rationale, with a research plan that is developed enough to show the work can realistically be carried out and can generate meaningful new avenues for BMF investigation.
A central expectation of this opportunity is a rigorous research approach that demonstrates deep knowledge of bone marrow failure biology and/or clinical challenges. Applicants are expected to lay out well-justified experimental strategies, whether those strategies are entirely novel or based on compelling prior evidence from published findings, literature synthesis, or any preliminary observations. The application should spell out feasibility in practical terms, including access to needed resources and documentation to support that access. Reviewers are also looking for thoughtful planning around what could go wrong: identifying likely pitfalls, proposing alternative strategies, and, where appropriate, including statistical and power analyses to justify study design and sample size.
Unlike some mechanisms that require extensive pilot results, preliminary data are optional here. Applicants can include unpublished data from the principal investigator or named collaborators, along with relevant published literature, but the program explicitly allows proposals that do not have new pilot results as long as the underlying rationale is logically strong and well supported by existing evidence. This structure is meant to encourage earlier-stage, high-potential concepts that may not yet have a large internal dataset but are still grounded in sound science.
Innovation and impact are major review drivers. The program is looking for work that introduces a new paradigm, challenges prevailing assumptions, or reframes a persistent problem in a way that could open up more effective prevention, detection, diagnosis, or treatment strategies for BMF. High-risk, high-reward ideas are acceptable and even encouraged, but the application must make a convincing case that success would matter in a substantial way for the field and, ideally, for patient care or quality of life. Proposals that amount to modest or incremental advances are not aligned with the intent of the award.
Team qualifications are treated as a critical component. The proposed personnel must collectively demonstrate strong bone marrow failure expertise, either through the principal investigator's background, the assembled research team, or clearly documented collaborations that fill any gaps. The opportunity is open to both established investigators and early career investigators, with different expectations for each. Established investigators are expected to be at least at the Associate Professor level (or equivalent) and to show BMF-related expertise backed by funding and publication history, along with appropriate effort and a collaboration plan that supports successful execution of the work.
Early career investigators are eligible as long as they are independent faculty at the Assistant Professor, Instructor, or Assistant Research Professor level (or equivalent), and within 10 years of completing a terminal degree (doctoral or medical). Time in medical residency and periods of family medical leave do not count toward the 10-year window, but postdoctoral time does count and must fall within the 10-year span. Applicants need to clearly document eligibility in their biographical sketch. Postdoctoral fellows are explicitly not eligible to apply as early career investigators under this mechanism. For early career applicants, reviewers also weigh evidence of readiness and support, including training that indicates the investigator can complete the proposed work and institutional commitment beyond money, such as protected research time, independent lab space, and meaningful collaboration opportunities. The FY16 program also set aside the possibility of funding one or more highly meritorious early career applications, and early career applicants are assessed using different personnel criteria during review.
Administratively, this opportunity (Funding Opportunity Number W81XWH-16-BMFRP-IDA) was posted on February 11, 2016, with an application deadline of July 13, 2016. It falls under science and technology research and development (CFDA 12.420) and supports awards via grants and cooperative agreements. Eligibility is broadly described as unrestricted, meaning a wide range of entity types may apply as long as they meet any specific requirements stated in the full announcement. The posting indicated an expectation of about five awards, and an explicit award ceiling was not listed in the provided data.
Frequently Asked Questions (FAQs): Bone Marrow Failure (BMF) Idea Development Award (BMFRP)
What is the Bone Marrow Failure (BMF) Idea Development Award?
The Bone Marrow Failure (BMF) Idea Development Award is a funding opportunity under the Department of Defense Bone Marrow Failure Research Program (BMFRP). It is intended to push the field toward the broader mission of understanding and curing bone marrow failure syndromes by supporting genuinely new and creative research directions.
What types of projects is this award trying to fund?
This mechanism is aimed at ideas that are innovative and potentially transformative, rather than projects that represent modest or incremental next steps. The program is looking for research that could introduce a new paradigm, challenge prevailing assumptions, or reframe a persistent problem in a way that could meaningfully improve prevention, detection, diagnosis, or treatment strategies for bone marrow failure.
Are incremental or continuation projects a good fit for this award?
No. Proposals that amount to modest or incremental advances are not aligned with the intent of the Idea Development Award. The emphasis is on genuinely new and creative research directions with clear potential for high impact.
Does the application need a hypothesis?
Yes. Projects are expected to be built around a clear, testable hypothesis that is supported by a strong scientific rationale.
How developed does the research plan need to be?
The research plan should be developed enough to show that the work can realistically be carried out and can generate meaningful new avenues for bone marrow failure investigation. The application should demonstrate feasibility in practical terms, including access to needed resources and documentation supporting that access.
Is preliminary data required?
No. Preliminary data are optional. The program allows proposals that do not include new pilot results as long as the underlying rationale is logically strong and well supported by existing evidence.
If preliminary data are optional, what kinds of support can be used to justify the idea?
Applicants may support the rationale using published findings, literature synthesis, or preliminary observations. Unpublished data from the principal investigator or named collaborators may also be included.
What does the program expect in terms of research rigor?
A central expectation is a rigorous research approach demonstrating deep knowledge of bone marrow failure biology and/or clinical challenges. Applicants are expected to lay out well-justified experimental strategies, whether entirely novel or based on compelling prior evidence.
Are applicants expected to include alternative approaches if something goes wrong?
Yes. Reviewers are looking for thoughtful planning around what could go wrong. Applications are expected to identify likely pitfalls and propose alternative strategies.
Are statistical and power analyses expected?
Where appropriate, applications should include statistical and power analyses to justify study design and sample size.
How important are innovation and impact in review?
Innovation and impact are major drivers in review. High-risk, high-reward ideas are acceptable and encouraged, but the application must make a convincing case that success would matter substantially for the field and, ideally, for patient care or quality of life.
Who can apply?
Eligibility is broadly described as unrestricted, meaning a wide range of entity types may apply as long as they meet any specific requirements stated in the full announcement.
Are both established and early career investigators eligible?
Yes. The opportunity is open to both established investigators and early career investigators, but expectations and review considerations differ for each.
What are the expectations for established investigators?
Established investigators are expected to be at least at the Associate Professor level (or equivalent). They should demonstrate bone marrow failure-related expertise supported by funding and publication history, and they should propose appropriate effort and a collaboration plan that supports successful execution of the work.
Who qualifies as an early career investigator under this award?
Early career investigators must be independent faculty at the Assistant Professor, Instructor, or Assistant Research Professor level (or equivalent), and must be within 10 years of completing a terminal degree (doctoral or medical), with specific rules about what time counts toward that window.
How is the 10-year early career window calculated?
Time in medical residency and periods of family medical leave do not count toward the 10-year window. Postdoctoral time does count and must fall within the 10-year span.
Are postdoctoral fellows eligible to apply as early career investigators?
No. Postdoctoral fellows are explicitly not eligible to apply as early career investigators under this mechanism.
How should early career investigators document eligibility?
Applicants need to clearly document early career eligibility in their biographical sketch.
What additional factors are considered for early career applicants?
Reviewers weigh evidence of readiness and support, including training indicating the investigator can complete the proposed work and institutional commitment beyond money, such as protected research time, independent lab space, and meaningful collaboration opportunities.
Does the program indicate any special consideration for early career applications?
Yes. The FY16 program indicated the possibility of funding one or more highly meritorious early career applications, and early career applicants are assessed using different personnel criteria during review.
How important is the research team and collaboration plan?
Team qualifications are a critical component. The proposed personnel must collectively demonstrate strong bone marrow failure expertise through the principal investigator, the research team, or clearly documented collaborations that fill any gaps.
What is the Funding Opportunity Number for this award?
The Funding Opportunity Number is W81XWH-16-BMFRP-IDA.
When was this opportunity posted and when was the application deadline?
It was posted on February 11, 2016, and the application deadline was July 13, 2016.
What CFDA number is associated with this opportunity?
The opportunity is under CFDA 12.420 (science and technology research and development).
What types of awards are used (grant vs. cooperative agreement)?
The program supports awards via grants and cooperative agreements.
How many awards were expected?
The posting indicated an expectation of about five awards.
Is there an award ceiling listed?
An explicit award ceiling was not listed in the provided data.
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