Opportunity Information: Apply for PA 13 141
Apply for PA 13 141
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Acute Kidney Injury in Older Adults (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Mar 14, 2013 and posted on Mar 14, 2013.
- Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts For profit organizations other than small businesses Special district governments Public and State controlled institutions of higher education Small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Private institutions of higher education Public housing authorities/Indian housing authorities County governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Acute Kidney Injury in Older Adults (R01)" (Funding Opportunity Number PA-13-141) supports investigator-initiated research focused on acute kidney injury (AKI) specifically as it occurs in older adults. The central aim is to build stronger scientific and clinical evidence around why AKI is becoming more common in older people, what makes this age group uniquely vulnerable, and which approaches actually improve outcomes both immediately and over the long term. The FOA is intentionally broad, inviting basic science, clinical research, translational studies, and health services or outcomes research, as long as the work is clearly tied to AKI in aging populations and leads toward better guidance for real-world diagnosis, prevention, and treatment.
The announcement highlights four major scientific areas that applications can address. First, it encourages studies on the epidemiology, causes, and risk factors for AKI in older adults. This can include work that clarifies how often AKI occurs in different care settings, identifies medical or social factors that raise risk (such as comorbidities, medications, frailty, or surgical exposures), and distinguishes age-related patterns in AKI triggers or clinical trajectories. Second, it calls for research on the pathophysiology of AKI in the aging kidney, including how aging biology changes kidney resilience, injury responses, and recovery. Importantly, it also emphasizes downstream effects, particularly how AKI contributes to the onset or progression of chronic kidney disease (CKD) and how kidney injury interacts with disease in other organs, recognizing that older adults often face multi-organ vulnerability.
Third, the FOA prioritizes early detection, diagnosis, and monitoring approaches for AKI in older patients. This includes efforts to improve how AKI is identified earlier or more accurately, whether through biomarkers, imaging, physiologic monitoring, electronic health record-based prediction tools, or refined clinical criteria that account for age-related baseline kidney changes. The underlying goal is to move beyond late recognition and toward timely, actionable detection that can change clinical decisions before injury becomes severe or irreversible. Fourth, the FOA invites prevention, treatment, and management strategies designed for older adults with AKI. Relevant topics could include testing interventions to prevent AKI in high-risk scenarios (for example, around procedures, infections, or medication exposures), optimizing supportive management once AKI occurs, improving post-AKI follow-up, and developing care pathways that reduce complications and readmissions.
A key feature of this opportunity is its emphasis on outcomes that matter for older adults, not only traditional clinical endpoints. While morbidity, mortality, and CKD progression are explicitly named, the FOA also calls attention to functional independence and quality of life, which are often central concerns in geriatric care. In other words, competitive applications are expected to connect AKI research to meaningful short- and long-term consequences, including whether patients regain prior function, avoid disability, and maintain independence after an AKI episode. Research under this initiative is expected to help translate growing knowledge about AKI in older populations into evidence-based guidance that clinicians and health systems can use.
The mechanism is the NIH R01 research project grant, and the opportunity is listed as discretionary funding in the grant category. It is associated with NIH program areas including Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) and Aging Research (CFDA 93.866), reflecting the cross-cutting nature of AKI across nephrology and aging science. Cost sharing or matching is not required. The FOA was posted March 14, 2013, with an original and final closing date of May 7, 2016, and it was archived June 7, 2016, meaning it is no longer open for new submissions under that specific announcement as written, though similar NIH opportunities may exist under newer FOAs.
Eligibility is broad and includes many types of U.S. organizations such as public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations (other than small businesses), and a wide range of government entities (state, county, city/township, special district, and independent school districts). The FOA also explicitly allows tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and other regional organizations. In addition, it extends eligibility to non-U.S. entities and foreign institutions, and it allows foreign components of U.S. organizations when consistent with NIH policy. It also names several categories of minority-serving and community-focused institutions (for example, HBCUs, Hispanic-serving institutions, AANAPISI institutions, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities), as well as faith-based and community-based organizations, and eligible federal agencies.
Overall, this grant opportunity is designed to expand the evidence base around AKI in older adults by supporting studies that clarify who is at risk and why, explain how aging changes kidney injury and recovery, improve early detection and monitoring, and develop prevention and management strategies that lead to better survival, less CKD progression, and stronger functional and quality-of-life outcomes for a rapidly growing segment of the population.
FAQs: NIH "Acute Kidney Injury in Older Adults (R01)" (PA-13-141)
What is the NIH funding opportunity PA-13-141?
PA-13-141 is an NIH Funding Opportunity Announcement titled "Acute Kidney Injury in Older Adults (R01)." It supports investigator-initiated research focused on acute kidney injury (AKI) specifically as it occurs in older adults, with the goal of strengthening scientific and clinical evidence that can improve diagnosis, prevention, and treatment in real-world care.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 Research Project Grant mechanism.
What is the central aim of this FOA?
The central aim is to build stronger evidence about why AKI is becoming more common in older adults, what makes older adults uniquely vulnerable, and which approaches improve outcomes in both the short and long term.
What types of research does the FOA encourage?
The FOA is intentionally broad and welcomes basic science, clinical research, translational studies, and health services/outcomes research, as long as the work is clearly tied to AKI in aging populations and contributes toward better guidance for diagnosis, prevention, and treatment.
Is the scope limited to a specific care setting?
No. The FOA allows studies that examine AKI across different care settings and encourages work that clarifies how often AKI occurs in various settings and how AKI presents or progresses in older adults.
What are the main scientific areas highlighted in the announcement?
The FOA highlights four major areas: (1) epidemiology, causes, and risk factors for AKI in older adults; (2) pathophysiology of AKI in the aging kidney and downstream effects; (3) early detection, diagnosis, and monitoring approaches tailored to older patients; and (4) prevention, treatment, and management strategies designed for older adults with AKI.
What topics fall under epidemiology, causes, and risk factors for AKI in older adults?
Examples include studies that estimate AKI frequency in different care settings, identify medical or social risk factors (such as comorbidities, medications, frailty, or surgical exposures), and distinguish age-related patterns in AKI triggers or clinical trajectories.
What does the FOA mean by studying pathophysiology of AKI in the aging kidney?
It refers to research on how aging biology changes kidney resilience, responses to injury, and recovery processes, including how these changes may alter AKI severity, repair, and outcomes in older adults.
Does the FOA address long-term kidney outcomes like chronic kidney disease (CKD)?
Yes. The announcement emphasizes downstream effects, including how AKI may contribute to the onset or progression of chronic kidney disease (CKD) in older adults.
Does the FOA consider interactions between kidney injury and other organs?
Yes. It explicitly recognizes multi-organ vulnerability in older adults and encourages research on how kidney injury interacts with disease in other organs.
What approaches are encouraged for early detection, diagnosis, and monitoring of AKI in older patients?
The FOA encourages efforts to identify AKI earlier or more accurately using approaches such as biomarkers, imaging, physiologic monitoring, electronic health record-based prediction tools, or refined clinical criteria that account for age-related baseline kidney changes.
What is the goal of improving early detection and monitoring?
The goal is to move beyond late recognition and toward timely, actionable detection that can change clinical decisions before injury becomes severe or irreversible.
What kinds of prevention, treatment, and management strategies are within scope?
Relevant topics include interventions to prevent AKI in high-risk scenarios (such as around procedures, infections, or medication exposures), optimizing supportive management after AKI occurs, improving post-AKI follow-up, and developing care pathways that reduce complications and readmissions in older adults.
What outcomes does the FOA consider important for older adults?
In addition to traditional clinical endpoints (morbidity, mortality, and CKD progression), the FOA highlights outcomes that matter in geriatric care, including functional independence and quality of life.
Does the FOA expect applications to connect AKI to real-world consequences for older patients?
Yes. Competitive applications are expected to link AKI research to meaningful short- and long-term consequences, including whether patients regain prior function, avoid disability, and maintain independence after an AKI episode.
What NIH program areas are associated with this FOA?
The opportunity is associated with NIH program areas including Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) and Aging Research (CFDA 93.866), reflecting the cross-cutting nature of AKI across nephrology and aging science.
What is the funding category for this opportunity?
It is listed as discretionary funding in the grant category.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
When was the FOA posted and what were the closing dates?
The FOA was posted on March 14, 2013. The original and final closing date was May 7, 2016.
Is PA-13-141 currently accepting applications?
No. The FOA was archived on June 7, 2016, which means it is no longer open for new submissions under that specific announcement as written.
Does the archive status mean NIH no longer funds AKI-in-older-adults research?
The information provided states only that this specific announcement is no longer open; it also notes that similar NIH opportunities may exist under newer FOAs.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations, such as public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations (other than small businesses), and a wide range of government entities (state, county, city/township, special district, and independent school districts).
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly allows tribal governments and tribal organizations, and it also includes tribally controlled colleges and universities among the named institution categories.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are explicitly included.
Are non-U.S. entities and foreign institutions eligible?
Yes. The FOA extends eligibility to non-U.S. entities and foreign institutions, and it allows foreign components of U.S. organizations when consistent with NIH policy.
Are minority-serving and community-focused institutions included?
Yes. The FOA names categories such as HBCUs, Hispanic-serving institutions, AANAPISI institutions, Alaska Native and Native Hawaiian Serving Institutions, and other community-focused institution types, along with faith-based and community-based organizations.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included among the eligible applicant types.
What is the overall purpose of the FOA?
Overall, the FOA is designed to expand the evidence base around AKI in older adults by supporting studies that clarify who is at risk and why, explain how aging changes kidney injury and recovery, improve early detection and monitoring, and develop prevention and management strategies that lead to better survival, less CKD progression, and stronger functional and quality-of-life outcomes.
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