Opportunity Information: Apply for RFA RM 13 010
Apply for RFA RM 13 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Sep 16, 2013 and posted on Sep 16, 2013.
- Applicants must submit their applications by Dec 11, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01) (RFA-RM-13-010) is a National Institutes of Health cooperative agreement opportunity aimed at speeding up functional understanding of the "druggable genome," specifically the many proteins that remain poorly characterized or not well annotated. The central idea is to move beyond slow, one-protein-at-a-time biology and instead adapt and deploy scalable, medium- to high-throughput technology platforms that can interrogate large groups of proteins in parallel. The work is expected to generate practical experimental pipelines, assays, and perturbation strategies that help reveal what these proteins do at the molecular and cellular levels, with an emphasis on building approaches that can be reused broadly across a protein class rather than producing isolated findings.
The FOA is tied to a broader, coordinated effort (referencing a companion announcement, RFA-RM-13-011) focused on both technology development/adaptation and the information management needed to organize and share the resulting functional data. In other words, this is not just a call for more experiments; it is a call to create end-to-end, streamlined workflows that combine robust assays, physiological perturbation protocols, and data handling practices so that large-scale functional studies become routine for under-studied targets. The target space is described as four protein classes within the druggable genome, with priority on members that are poorly characterized and/or unannotated, and the expectation is that applicants will propose scalable strategies that can illuminate many members of those classes efficiently and consistently.
Because the mechanism is a U01 cooperative agreement, awardees should anticipate substantial scientific and programmatic involvement from NIH staff compared with a standard investigator-initiated grant. This typically means the project will be run in a more team-science, milestone-driven way, with coordination and expectations around sharing methods, data, and outputs that can accelerate the broader program goals. The activity category is health (CFDA 93.310, Trans-NIH Research Support), reinforcing that the emphasis is on enabling technologies and knowledge that can ultimately support drug discovery and translational research by expanding the set of targets with known biology.
On the administrative side, the opportunity was posted September 16, 2013, with an original and current closing date of December 11, 2013, and an archive date of January 11, 2014. The estimated total funding listed is $2,500,000, and the award ceiling is $275,000. There is no cost-sharing or matching requirement stated. Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses and for-profits other than small businesses), and additional categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs. Importantly, non-U.S. entities are explicitly eligible: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by the NIH Grants Policy Statement.
Overall, the opportunity is best understood as a push to build and standardize scalable experimental and data workflows that can rapidly assign or clarify biological function across under-studied druggable proteins, producing platforms and protocols that are transformative in throughput and reproducibility. The funding is intended to catalyze technology adaptation and integrated assay/perturbation pipelines that make it feasible to systematically "light up" dark areas of the druggable genome, creating functional insights and organized information resources that the wider research community can build on. For full details, NIH pointed applicants to the official announcement page at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-010.html, and provided NIH OER webmaster contacts for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01)" and is identified as RFA-RM-13-010.
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What funding mechanism is used (and what does U01 mean here)?
The mechanism is a U01 cooperative agreement. This indicates that, compared with a typical investigator-initiated research grant, awardees should expect substantial scientific and programmatic involvement from NIH staff and a more coordinated, milestone-driven, team-science approach.
What is the main purpose of the FOA?
The purpose is to speed up functional understanding of the "druggable genome," especially proteins that are poorly characterized or not well annotated, by adapting and deploying scalable, medium- to high-throughput technology platforms that can interrogate many proteins in parallel.
What does "druggable genome" mean in the context of this FOA?
In this FOA, the "druggable genome" refers to proteins considered potential drug targets, including many members that remain poorly characterized or unannotated, and therefore represent "dark" areas where biological function is not well understood.
What kind of projects is NIH trying to move away from?
The FOA explicitly emphasizes moving beyond slow, one-protein-at-a-time biology and instead building approaches that can be applied across large groups of proteins efficiently and consistently.
What types of technologies or approaches are expected?
Applicants are expected to adapt and deploy scalable, medium- to high-throughput technology platforms and create practical experimental pipelines, assays, and perturbation strategies that reveal protein function at molecular and cellular levels.
What does "scalable" mean in this program?
"Scalable" refers to methods and workflows that can be applied to many proteins (for example, across an entire protein class) using consistent procedures, rather than producing isolated findings for single targets.
What kinds of outputs are emphasized?
The FOA emphasizes reusable platforms and end-to-end workflows, including robust assays, physiological perturbation protocols, and data handling practices, so that large-scale functional studies become routine for under-studied targets.
Is the goal to produce isolated biological discoveries about individual proteins?
No. The emphasis is on developing approaches that can be reused broadly across a protein class, rather than generating isolated, one-off findings.
How many protein classes are targeted?
The target space is described as four protein classes within the druggable genome.
Which proteins within those classes are prioritized?
Priority is placed on members that are poorly characterized and/or unannotated.
How does this FOA relate to other NIH efforts mentioned in the description?
This FOA is part of a broader coordinated effort and references a companion announcement, RFA-RM-13-011, which together cover both technology development/adaptation and the information management needed to organize and share functional data.
Does this opportunity include expectations about information management and data organization?
Yes. The program is described as not only a call for more experiments, but also a push for streamlined workflows that combine assays and perturbation protocols with data handling practices to support large-scale functional studies and sharing.
What is the activity category and CFDA number listed?
The activity category is health, and the CFDA number provided is 93.310 (Trans-NIH Research Support).
What is the estimated total funding amount for this opportunity?
The estimated total funding listed is $2,500,000.
What is the award ceiling?
The award ceiling is $275,000.
Is cost sharing or matching required?
No cost-sharing or matching requirement is stated in the information provided.
When was the opportunity posted?
The opportunity was posted on September 16, 2013.
What was the application closing date?
The original and current closing date listed is December 11, 2013.
When was the opportunity archived?
The archive date is January 11, 2014.
Who is eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), and for-profit organizations (including small businesses and for-profits other than small businesses).
Are minority-serving institutions included in the eligible organization types?
Yes. The eligible categories listed include HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs.
Can non-U.S. organizations apply?
Yes. Non-U.S. entities are explicitly eligible. Foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by the NIH Grants Policy Statement.
Is this opportunity focused on technology adaptation, data resources, or both?
It is described as part of a coordinated effort covering both technology development/adaptation and the information management needed to organize and share resulting functional data, with an emphasis on integrated, end-to-end workflows.
What is the overarching practical aim for the research community?
The aim is to make large-scale functional studies routine for under-studied druggable targets by catalyzing standardized, reproducible platforms and protocols and producing functional insights and organized information resources others can build on.
Where can applicants find the official announcement?
NIH directed applicants to the official announcement page at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-010.html.
Who should be contacted for access or linking issues related to the official posting?
The information provided mentions NIH OER webmaster contacts for access or linking issues.
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