Opportunity Information: Apply for RFA RM 13 011
Apply for RFA RM 13 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of a Knowledge Management Center for Illuminating the Druggable GenomeTitle Here (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Sep 16, 2013 and posted on Sep 16, 2013.
- Applicants must submit their applications by Dec 11, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $3,000,000.00 in funding.
- Eligible applicants include: Private institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This NIH funding opportunity, RFA-RM-13-011, supports the creation of a Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) program under the NIH Common Fund. The central purpose of IDG is to push the scientific community beyond the usual, heavily studied drug targets by improving what is known about proteins that are currently poorly characterized or insufficiently annotated. The focus is specifically on proteins that fall within four of the most commonly drug-targeted protein families, where many members still lack basic functional, mechanistic, or biological-context information. In practical terms, NIH is aiming to shrink the knowledge gap between well-known targets and the large number of understudied proteins that may be medically relevant but are not yet tractable because the data, tools, and annotations are fragmented or incomplete.
The KMC is one of two coordinated components of the broader IDG effort. This FOA funds the KMC side, while a companion FOA (RFA-RM-13-010) supports a Technology Development Initiative. The KMC is intended to function as the program’s informatics and integration backbone: a centralized hub that can gather, organize, curate, and disseminate data and knowledge about these understudied proteins in ways that make the information useful to researchers. Although the short description does not spell out all deliverables, a KMC in this context generally implies responsibilities like building and maintaining knowledge resources, linking disparate datasets and annotations, enabling search and prioritization of targets, supporting standardization where possible, and ensuring that outputs from the technology development projects and other community efforts are captured and made accessible. Because the award mechanism is a U54 cooperative agreement, the work is expected to be carried out in close collaboration with NIH program staff, with substantial scientific and programmatic involvement from the agency rather than a fully investigator-directed grant.
Administratively, this is a discretionary, health-related NIH opportunity using the cooperative agreement funding instrument. The CFDA listing is 93.310 (Trans-NIH Research Support), and the opportunity does not require cost sharing or matching. The total estimated funding amount is listed as $3,000,000, with an award ceiling also at $3,000,000, indicating NIH anticipated up to one award at roughly that level for the project period described in the full announcement. The FOA was posted on September 16, 2013, with an original and current closing date of December 11, 2013, and an archive date of January 11, 2014, meaning it was a time-limited solicitation tied to the initial launch phase of the IDG program.
Eligibility is broad across U.S.-based research performers. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education), for-profit organizations other than small businesses, and small businesses. The solicitation also explicitly highlights several institution types as eligible, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions, as well as eligible federal agencies. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components, as defined by NIH policy, are allowed, which typically means a U.S. applicant may include certain justified international collaborations or activities under NIH rules while still maintaining the domestic applicant organization as the prime awardee.
For anyone seeking the official requirements, expectations, and application instructions, NIH provided the full announcement at the grants.nih.gov link included in the notice. Technical access issues were directed to the NIH Office of Extramural Research webmaster contacts listed in the announcement.
Frequently Asked Questions (FAQs)
What is this NIH funding opportunity?
This opportunity is NIH FOA RFA-RM-13-011. It supports the creation of a Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) program under the NIH Common Fund.
What is the main purpose of the Illuminating the Druggable Genome (IDG) program?
The central purpose of IDG is to move the research community beyond the usual, heavily studied drug targets by improving what is known about proteins that are currently poorly characterized or insufficiently annotated. NIH is aiming to reduce the knowledge gap between well-known targets and the large number of understudied proteins that may be medically relevant but are not yet tractable due to fragmented or incomplete data, tools, and annotations.
What types of proteins are the focus of this program?
The focus is on proteins within four of the most commonly drug-targeted protein families, specifically those members that still lack basic functional, mechanistic, or biological-context information.
What is the Knowledge Management Center (KMC) expected to do?
The KMC is intended to serve as the IDG program's informatics and integration backbone. It is meant to operate as a centralized hub to gather, organize, curate, and disseminate data and knowledge about understudied proteins so the information is useful to researchers.
What kinds of activities are implied for the KMC based on the description provided?
While the short description does not list every deliverable, a KMC in this context generally implies responsibilities such as building and maintaining knowledge resources, linking disparate datasets and annotations, enabling search and prioritization of targets, supporting standardization where possible, and ensuring that outputs from technology development projects and other community efforts are captured and made accessible.
How does this KMC funding opportunity relate to the broader IDG effort?
The KMC is one of two coordinated components of IDG. This FOA (RFA-RM-13-011) funds the KMC component, while a companion FOA (RFA-RM-13-010) supports a Technology Development Initiative.
What is the award mechanism for this opportunity?
The award mechanism is a U54 cooperative agreement.
What does it mean that this is a U54 cooperative agreement?
It means the work is expected to be carried out in close collaboration with NIH program staff, with substantial scientific and programmatic involvement from NIH rather than being fully investigator-directed.
What is the funding instrument type described here?
This is described as a discretionary, health-related NIH opportunity using the cooperative agreement funding instrument.
What is the CFDA number associated with this opportunity?
The CFDA listing provided is 93.310 (Trans-NIH Research Support).
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
How much funding is available through this FOA?
The total estimated funding amount is listed as $3,000,000, and the award ceiling is also $3,000,000. This indicates NIH anticipated up to one award at roughly that level for the project period described in the full announcement.
When was the FOA posted, and what were the key dates?
The FOA was posted on September 16, 2013. The original and current closing date was December 11, 2013. The archive date was January 11, 2014.
Is this a time-limited solicitation?
Yes. The closing and archive dates indicate it was a time-limited solicitation tied to the initial launch phase of the IDG program.
Who is eligible to apply?
Eligibility is broad across U.S.-based research performers. Eligible applicants include public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are minority-serving institutions and tribally controlled institutions eligible?
Yes. The solicitation explicitly highlights that several institution types are eligible, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions.
Are federal agencies eligible to apply?
Yes. The eligibility list includes eligible federal agencies.
Are foreign institutions eligible to apply as the applicant organization?
No. Foreign institutions are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed in any form?
Yes. Foreign components, as defined by NIH policy, are allowed. This typically means a U.S. applicant may include certain justified international collaborations or activities under NIH rules while maintaining the domestic U.S. organization as the prime awardee.
Where can applicants find the official requirements and application instructions?
NIH provided the full announcement at the grants.nih.gov link included in the notice. The full announcement is the authoritative source for requirements, expectations, and application instructions.
Where should technical access issues be directed?
Technical access issues were directed to the NIH Office of Extramural Research webmaster contacts listed in the announcement.
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