Administrative Supplements for Research on HIV/AIDS and Aging (Admin Supp) | Apply Online

Opportunity Summary:

The Administrative Supplements for Research on HIV/AIDS and Aging (Admin Supp) opportunity (Funding Opportunity Number PA 15-137) was a National Institutes of Health (NIH) discretionary grant initiative designed to add targeted, short-term funding to existing NIH-supported projects so they could pursue new, innovative work focused specifically on HIV/AIDS in the context of aging. Rather than funding brand-new standalone grants, this program supported administrative supplements, meaning the proposed supplemental research had to fit clearly within the approved scientific scope of an active "parent" NIH award that was eligible for supplementation under NIH rules. The intent was to help investigators rapidly expand ongoing research into important questions at the intersection of HIV and older adulthood, using clinical, translational, observational, or interventional approaches, and allowing studies to be conducted either in the United States or internationally.

The scientific focus centered on understanding how HIV infection and HIV-related health issues play out as people age, especially as the population of older adults living with HIV has grown due to improved effectiveness and access to antiretroviral therapy. The announcement highlighted broad topic areas that could be addressed through supplements, including HIV infection itself, HIV-associated conditions and comorbidities, HIV treatment issues (such as long-term effects of therapy, adherence challenges, or treatment outcomes in older adults), and biobehavioral and social factors tied to HIV/AIDS when considered through an aging lens. In practice, this could include research on age-related differences in disease progression, interactions between HIV and chronic conditions more common in later life, neurocognitive or mental health outcomes, substance use and addiction factors, social support and stigma, health disparities, and other determinants that shape health and care engagement for older people living with or affected by HIV.

Programmatically, the effort was led by the NIH Office of AIDS Research in collaboration with multiple NIH Institutes and Centers, reflecting a cross-cutting interest spanning aging, infectious disease, mental health, substance use, neuroscience, nursing research, and cancer-related areas. This is reflected in the wide range of CFDA listings associated with the opportunity, which included research and training in complementary and integrative health (93.213), mental health research (93.242), alcohol research programs (93.273), drug abuse and addiction research programs (93.279), nursing research (93.361), multiple cancer research categories (93.393 through 93.399), extramural neuroscience and neurological disorders programs (93.853), allergy and infectious diseases research (93.855), microbiology and infectious diseases research (93.856), and aging research (93.866). The breadth of these categories signaled that HIV and aging questions were expected to intersect with many disease areas and disciplines, and that supplemental projects could be framed from a variety of scientific perspectives as long as they stayed within the parent grant's approved scope.

From a funding and administrative standpoint, the opportunity listed an estimated total funding amount of $2,000,000, with an award ceiling of $100,000 per supplement. There was no cost sharing or matching requirement. The posting and creation date were March 11, 2015, with an original and current closing date of May 15, 2015, and an archive date of June 15, 2015, indicating this was a time-limited supplement initiative rather than an open-ended program. Applicants were directed to the full announcement hosted on the NIH grants site (grants.nih.gov) under PA-15-137 for complete details on eligible parent award mechanisms, application instructions, and NIH-specific supplement policies.

Eligibility was broad and inclusive, covering many organization types that commonly participate in NIH research. Eligible applicants included nonprofit organizations (with or without 501(c)(3) status), public and private institutions of higher education, small businesses, for-profit organizations other than small businesses (as specified), state and local governments (including county, city/township, special district governments), independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations (including federally recognized tribal governments). The announcement also explicitly included a range of institution types and communities often emphasized in federal research participation goals, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISISs). Foreign (non-U.S.) entities and regional organizations were listed as eligible as well, along with U.S. territories or possessions and eligible federal agencies, reflecting NIH's ability to support research in diverse settings when scientifically justified and aligned with program priorities.

Overall, PA-15-137 was structured to accelerate progress on real-world, near-term research questions about HIV in older adults by leveraging existing NIH-funded projects and infrastructure. By using the administrative supplement mechanism, NIH aimed to encourage timely additions to ongoing studies, enabling investigators to collect new data, test focused hypotheses, or add aging-relevant measures or cohorts related to HIV infection, treatment, comorbidities, and the social and behavioral factors that influence outcomes for aging populations affected by HIV/AIDS.

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