Opportunity Information: Apply for PA 14 027

  • The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.307 Minority Health and Health Disparities Research 93.313 NIH Office of Research on Womens Health 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research 93.879 Medical Library Assistance 93.989 International Research and Research Training.
  • This funding opportunity was created on Dec 11, 2013 and posted on Dec 11, 2013.
  • Applicants must submit their applications by Feb 6, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 50 candidate(s).
  • Eligible applicants include: Special district governments Public housing authorities/Indian housing authorities City or township governments County governments Native American tribal governments (Federally recognized) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses State governments Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The National Institutes of Health (NIH), through the Office of Research on Womens Health (ORWH), offered an administrative supplement opportunity titled "Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)" under funding opportunity number PA-14-027. The main purpose of this program was to provide additional, targeted funding to existing NIH-supported projects so investigators could expand or add work that directly examines sex/gender differences or similarities, or more broadly explores how sex and gender as biological and social variables influence health and disease. The program was open to a wide range of study types, including preclinical, clinical, and behavioral research, as long as the proposed supplement work stayed clearly connected to the parent award and strengthened the scientific focus on sex/gender considerations.

The scientific emphasis was on research that could clarify how sex- and gender-related factors shape human health and illness across the full translational spectrum. ORWH highlighted particular interest in studies that dig into molecular, cellular, and systems biology mechanisms underlying disease and pathophysiology, as well as work that addresses how diseases may differ in clinical presentation between sexes/genders and how prevention strategies or treatments might need to be tailored accordingly. In practical terms, the supplement could support adding sex as a variable in analyses, powering a study to detect sex-based effects, integrating sex/gender-informed measures into an ongoing protocol, or extending mechanistic work to explain observed differences. A key requirement was that the supplement proposal align with at least one objective under Goals 1 through 3 of the NIH Strategic Plan for Womens Health Research, signaling that projects needed to fit within NIH-wide priorities for advancing womens health research and integrating sex and gender considerations into biomedical science.

Administratively, this was a discretionary grant supplement mechanism rather than a standalone new grant competition, with an expected number of awards around 50 and an estimated total funding level of about $5,000,000. There was no cost sharing or matching requirement. The opportunity was posted on December 11, 2013, and closed on February 6, 2014, with an archive date of March 9, 2014. The activity category listing was broad (including areas such as education, environment, food and nutrition, health, income security, and social services), reflecting the wide range of NIH research domains where sex/gender variables can be relevant rather than restricting the topic to a single disease area.

Eligibility was expansive and included many U.S.-based organizational types typically eligible for NIH funding. Eligible applicants included state, county, and municipal governments; special district governments; tribal governments and tribal organizations; public and private institutions of higher education; nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits); for-profit organizations other than small businesses; and small businesses. The eligibility language also explicitly recognized a variety of mission-focused and underserved-serving institutions and entities, including Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies. At the same time, the announcement clearly excluded non-U.S. entities: foreign institutions were not eligible to apply, non-U.S. components of U.S. organizations were not eligible, and foreign components as defined by NIH policy were not allowed.

The opportunity spanned many NIH program areas, as reflected in the long list of CFDA numbers tied to institutes and centers covering environmental health, oral health, deafness and communication disorders, complementary and integrative health, sleep, mental health, alcohol and drug abuse, minority health and health disparities, cancer, cardiovascular and pulmonary diseases, blood disorders, arthritis and musculoskeletal conditions, diabetes and digestive and kidney diseases, neuroscience, allergy and infectious diseases, child health and human development, aging, vision, and more. This breadth underscores the program's central message: sex and gender considerations matter across nearly every area of health research, and NIH sought to accelerate progress by helping active projects incorporate these factors more rigorously and systematically.

For full program details, the official announcement was linked at http://grants.nih.gov/grants/guide/pa-files/PA-14-027.html, and NIH listed the NIH Office of Extramural Research (OER) webmaster contact for access or technical issues (FBOWebmaster@OD.NIH.GOV).

FAQs: NIH ORWH Administrative Supplements for Research on Sex/Gender Differences (PA-14-027)

What is the PA-14-027 opportunity?

PA-14-027 is an NIH administrative supplement opportunity from the Office of Research on Women's Health (ORWH) titled "Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)." It provided additional, targeted funding to expand existing NIH-supported projects with work that directly examines sex/gender differences or similarities, or more broadly explores sex and gender as biological and social variables in health and disease.

Is this a new standalone grant, or a supplement to an existing award?

This was a discretionary administrative supplement mechanism, not a standalone new grant competition. The supplement work had to remain clearly connected to (and build on) an existing NIH-supported parent award.

What was the main purpose of this supplement program?

The program aimed to strengthen ongoing NIH-funded research by adding or expanding components that rigorously address sex and gender considerations. The intent was to accelerate progress in understanding how sex- and gender-related factors shape health and illness across the translational spectrum.

What types of research were supported?

A wide range of study types were within scope, including preclinical, clinical, and behavioral research, as long as the proposed supplement activities were clearly tied to the parent award and sharpened the scientific focus on sex/gender differences or similarities.

What scientific topics did ORWH emphasize?

ORWH highlighted interest in research that clarifies mechanisms (molecular, cellular, and systems biology) underlying disease and pathophysiology, as well as studies examining differences in clinical presentation between sexes/genders and how prevention strategies or treatments might need to be tailored accordingly.

What are examples of supplement activities that fit this opportunity?

Examples mentioned include adding sex as a variable in analyses, powering a study to detect sex-based effects, integrating sex/gender-informed measures into an ongoing protocol, and extending mechanistic work to explain observed differences.

Does the supplement work have to be connected to the parent award?

Yes. A key condition was that the proposed supplement activities stay clearly connected to the existing NIH-supported parent project and strengthen its focus on sex/gender considerations.

Was alignment with NIH-wide priorities required?

Yes. The supplement proposal needed to align with at least one objective under Goals 1 through 3 of the NIH Strategic Plan for Women's Health Research.

How many awards were expected, and what was the estimated total funding?

The opportunity listed an expected number of awards of about 50 and an estimated total funding level of roughly $5,000,000.

Was cost sharing or matching required?

No. The announcement stated there was no cost sharing or matching requirement.

When was the opportunity posted and when did it close?

The opportunity was posted on December 11, 2013, and closed on February 6, 2014. An archive date of March 9, 2014 was also listed.

What is the funding opportunity number for this program?

The funding opportunity number was PA-14-027.

Which applicant organization types were eligible?

Eligibility included many U.S.-based organization types commonly eligible for NIH funding, such as state, county, and municipal governments; special district governments; tribal governments and tribal organizations; public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits); for-profit organizations other than small businesses; and small businesses.

Were specific institution types and community-focused entities explicitly recognized as eligible?

Yes. The eligibility language explicitly recognized HBCUs, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs. It also referenced faith-based or community-based organizations and eligible federal agencies.

Are foreign organizations eligible to apply?

No. The announcement excluded non-U.S. entities: foreign institutions were not eligible, non-U.S. components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed.

Was the topic limited to a specific disease area?

No. The opportunity was intentionally broad, reflecting that sex and gender variables can be relevant across many NIH research domains rather than focusing on a single disease area.

What NIH areas or programs did this opportunity span?

The announcement referenced a wide range of NIH program areas (via many CFDA numbers), including domains such as environmental health, oral health, communication disorders, complementary and integrative health, sleep, mental health, alcohol and drug abuse, minority health and health disparities, cancer, cardiovascular and pulmonary diseases, blood disorders, arthritis and musculoskeletal conditions, diabetes and digestive and kidney diseases, neuroscience, allergy and infectious diseases, child health and human development, aging, and vision, among others.

What does the broad activity category listing imply?

The activity category listing was broad (including areas like education, environment, food and nutrition, health, income security, and social services). This reflects the wide range of NIH research contexts where sex/gender variables may be relevant, rather than restricting the supplement to one narrow topic.

Where can I find the official announcement details?

The official announcement was linked at http://grants.nih.gov/grants/guide/pa-files/PA-14-027.html.

Who was listed for technical or access issues?

NIH listed the NIH Office of Extramural Research (OER) webmaster contact for access or technical issues: FBOWebmaster@OD.NIH.GOV.

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