Opportunity Information: Apply for PA 14 026
Apply for PA 14 026
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Basic Mechanisms of Brain Development for Substance Use and Dependence (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 11, 2013 and posted on Dec 11, 2013.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Special district governments Independent school districts City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education County governments Native American tribal governments (Federally recognized) State governments For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Basic Mechanisms of Brain Development for Substance Use and Dependence (R01)" (Funding Opportunity Number PA-14-026) supports Research Project Grant (R01) applications that investigate how the brain develops in ways that shape vulnerability to substance use, substance dependence, and related psychiatric conditions. The core intent is basic neuroscience: understanding fundamental developmental processes in the nervous system and identifying how those processes intersect with the brain circuits that drive emotional behavior, motivation, learning, and decision-making, all of which are tightly linked to addiction risk and substance-related harms.
A central focus of this announcement is research on the developing brain, broadly defined to include all developmental stages, while placing special emphasis on prepuberty and adolescence. The FOA highlights these periods because they involve rapid and highly organized changes in neural circuitry, cellular maturation, and molecular signaling, and because substance exposure during these windows may have outsized and long-lasting effects. Proposals are encouraged to connect developmental mechanisms to real addiction-relevant outcomes, such as altered reward sensitivity, stress responsivity, impulse control, habit formation, and other processes that influence initiation of substance use, escalation, and persistence.
The scientific scope explicitly includes studying brain regions and neural systems that mediate emotional and motivated behavior, particularly those implicated in substance use and dependence. Projects may address the euphoric or reinforcing properties of abused substances, how these effects vary across developmental stages, and how exposure changes brain function over time. The announcement also calls out interest in the actions of psychotherapeutic agents and their consequences for memory, cognition, and emotional processes in the context of development. In addition to behavioral or systems-level work, a major goal is mechanistic: determining how exposure to substances of abuse influences cellular and molecular pathways that guide nervous system development, including how these exposures alter the formation, refinement, and function of neural circuits involved in substance use and addiction. The FOA also emphasizes comorbidity, encouraging research that links developmental neurobiology to the overlap between substance use disorders and psychiatric disorders.
Administratively, this is a discretionary grant opportunity using the NIH R01 mechanism, which typically supports hypothesis-driven projects led by a principal investigator and carried out at eligible institutions or organizations. The program is associated with CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs), reflecting the alcohol and drug abuse research missions within NIH. There is no cost sharing or matching requirement stated for applicants.
Eligibility is broad and includes many types of domestic and non-domestic applicants. Eligible organizations include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, and for-profit organizations other than small businesses, along with various levels of government (state, county, city/township), independent school districts, special district governments, and public housing authorities/Indian housing authorities. The FOA also explicitly includes a wide range of mission-specific or community-rooted institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions, as well as faith-based and community-based organizations. Foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined in NIH policy) are allowed, indicating NIH openness to internationally situated expertise when justified by the science.
Key dates in the source record indicate the opportunity was posted on December 11, 2013, with an original and current closing date of January 7, 2017, and an archive date of February 7, 2017. While those dates suggest the specific announcement is no longer open, the summary still reflects the program priorities and the kind of research NIH sought under this reissued initiative. The full announcement was hosted by NIH at http://grants.nih.gov/grants/guide/pa-files/PA-14-026.html, and technical access issues were routed to the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH "Basic Mechanisms of Brain Development for Substance Use and Dependence (R01)" (PA-14-026)
1) What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity titled "Basic Mechanisms of Brain Development for Substance Use and Dependence (R01)." It supports Research Project Grant (R01) applications focused on basic neuroscience questions about how brain development shapes vulnerability to substance use, substance dependence, and related psychiatric conditions.
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number listed is PA-14-026.
3) What grant mechanism does this opportunity use?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which generally supports hypothesis-driven research led by a principal investigator at an eligible organization.
4) What is the main scientific goal of the FOA?
The central intent is basic neuroscience: understanding fundamental developmental processes in the nervous system and identifying how those processes intersect with brain circuits involved in emotional behavior, motivation, learning, and decision-making, since those systems are tightly linked to addiction risk and substance-related harms.
5) What developmental periods does NIH emphasize in this FOA?
The FOA is broadly about the developing brain across developmental stages, with special emphasis on prepuberty and adolescence. These periods are highlighted because they involve rapid, highly organized changes in neural circuitry, cellular maturation, and molecular signaling, and because substance exposure during these windows may have outsized and long-lasting effects.
6) Does the FOA require projects to connect development to addiction-relevant outcomes?
Yes. Proposals are encouraged to link developmental mechanisms to outcomes relevant to addiction and substance-related harms, including altered reward sensitivity, stress responsivity, impulse control, habit formation, and other processes influencing initiation, escalation, and persistence of substance use.
7) What kinds of brain systems or functions are within scope?
The scope explicitly includes brain regions and neural systems that mediate emotional and motivated behavior, particularly those implicated in substance use and dependence. It also includes developmental influences on circuits that support motivation, learning, and decision-making.
8) Can projects study how the reinforcing or euphoric effects of substances vary by age or developmental stage?
Yes. The FOA notes interest in the euphoric or reinforcing properties of abused substances, how those effects vary across developmental stages, and how exposure changes brain function over time.
9) Is research on cellular and molecular developmental mechanisms encouraged?
Yes. A major goal is mechanistic research on how exposure to substances of abuse influences cellular and molecular pathways guiding nervous system development, including how exposure alters the formation, refinement, and function of neural circuits involved in substance use and addiction.
10) Does the FOA include interest in psychotherapeutic agents?
Yes. The FOA calls out interest in the actions of psychotherapeutic agents and their consequences for memory, cognition, and emotional processes in the context of development.
11) Is comorbidity with psychiatric disorders part of the research scope?
Yes. The FOA emphasizes comorbidity and encourages research linking developmental neurobiology to overlap between substance use disorders and psychiatric disorders.
12) Is the focus applied intervention research or basic research?
Based on the description provided, the core intent is basic neuroscience research aimed at understanding fundamental developmental processes and mechanisms relevant to vulnerability, risk, and trajectories related to substance use and dependence.
13) Are there specific CFDA numbers associated with this program?
Yes. The program is associated with CFDA 93.273 (Alcohol Research Programs) and CFDA 93.279 (Drug Abuse and Addiction Research Programs).
14) Is cost sharing or matching required?
No cost sharing or matching requirement is stated for applicants in the information provided.
15) Who is eligible to apply (organizational eligibility)?
Eligibility is broad and includes many domestic and non-domestic applicants. Eligible organizations include public and private institutions of higher education; nonprofits with or without 501(c)(3) status; small businesses; for-profit organizations other than small businesses; and various government entities (state, county, city/township), independent school districts, special district governments, and public housing authorities/Indian housing authorities.
16) Are minority-serving or community-rooted institutions explicitly included?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions, as well as faith-based and community-based organizations.
17) Can foreign organizations apply?
Yes. Foreign organizations and foreign institutions may apply. In addition, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined in NIH policy) are allowed.
18) Does the FOA allow non-U.S. components or foreign components if scientifically justified?
Yes. The information provided indicates NIH openness to internationally situated expertise when justified by the science, since foreign organizations may apply and foreign components are allowed under NIH policy definitions.
19) When was this opportunity posted, and what were the listed closing dates?
The source record indicates the opportunity was posted on December 11, 2013. It lists an original and current closing date of January 7, 2017, with an archive date of February 7, 2017.
20) Is this specific FOA still open for applications?
Based on the dates provided (closing date January 7, 2017 and archive date February 7, 2017), this specific announcement appears to be no longer open.
21) Where was the full announcement hosted?
The full announcement was hosted by NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-14-026.html
22) Who should be contacted for technical access issues related to the announcement?
Technical access issues were routed to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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