Opportunity Information: Apply for PA 09 206

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Advanced Tools and Technologies for Cerebrospinal Fluid Shunts SBIR (R43/R44)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Jun 8, 2009 and posted on Jun 8, 2009.
  • Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses.
Apply for PA 09 206

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Opportunity Summary:

The Advanced Tools and Technologies for Cerebrospinal Fluid Shunts SBIR (R43/R44) opportunity (Funding Opportunity Number PA-09-206) is a National Institutes of Health (NIH) discretionary grant program aimed at helping small businesses create better tools and technologies for cerebrospinal fluid (CSF) shunts used to treat hydrocephalus. The central goal is practical, product-oriented innovation: supporting research and development that can modernize shunt systems and related technologies in ways that measurably improve clinical care and patient outcomes. In other words, this is not a general basic science solicitation. It is focused on enabling small companies to design, build, and validate improved shunt-related technologies that address real-world clinical limitations in current hydrocephalus treatment.

The program uses the Small Business Innovation Research (SBIR) mechanisms R43/R44, which cover Phase I, Phase II, and Fast Track applications. Phase I generally supports early feasibility work such as proof-of-concept demonstrations, prototype development, and initial performance testing, while Phase II supports more advanced R and D such as refinement, verification and validation activities, and steps that move a technology closer to clinical use and commercialization. The Fast Track option is available for applicants who want to propose a streamlined path from Phase I into Phase II when the project rationale and development plan justify an accelerated progression. The FOA also explicitly notes that it runs in parallel with a scientifically identical companion announcement for the Small Business Technology Transfer (STTR) program (PA-09-205; R41/R42), which is relevant for teams planning a formal collaboration with a research institution under the STTR rules. In practice, the SBIR track is designed for projects primarily led by the small business, while STTR is structured around a required small business-research institution partnership; this FOA highlights that applicants have both pathways available depending on how their team and work plan are organized.

Eligibility is limited to small business concerns, and there is no cost sharing or matching requirement, which lowers the barrier for early-stage companies that may not have substantial non-dilutive capital available. The opportunity is categorized under Health, Income Security, and Social Services, and it is associated with CFDA program numbers 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and 93.865 (Child Health and Human Development Extramural Research), reflecting NIH programmatic interests that span neurological disorders and pediatric and developmental health needs often affected by hydrocephalus.

Funding levels and the number of awards are not fixed in advance. Instead, awards are described as contingent on the availability of appropriated funds and on the submission of a sufficient number of high-quality, meritorious applications. NIH emphasizes that both the total amount awarded and the number of projects supported will vary depending on the quality, project duration, and proposed costs across applications received. That framing signals a competitive, peer-reviewed process typical of NIH: strong scientific and technical merit, a credible development plan, and appropriate budget justification will matter more than trying to fit into a predetermined number of awards.

Administratively, the FOA was posted June 8, 2009, with an original and final closing date of May 7, 2012, and it was archived June 7, 2012. The sponsoring agency is NIH, and the full announcement was hosted through the NIH Grants Guide. The notice also provides support contacts through the NIH Office of Extramural Research (OER) webmaster email for access or linking issues, which is mainly relevant for applicants navigating the online posting rather than scientific questions. Overall, the opportunity is best understood as NIH-backed SBIR support for small businesses developing next-generation CSF shunt technologies intended to improve hydrocephalus management, with funding routed through phased SBIR development awards and evaluated competitively based on merit and feasibility.

FAQs: Advanced Tools and Technologies for Cerebrospinal Fluid Shunts SBIR (R43/R44) - PA-09-206

What is this funding opportunity?

This is an NIH Small Business Innovation Research (SBIR) funding opportunity titled "Advanced Tools and Technologies for Cerebrospinal Fluid Shunts SBIR (R43/R44)" under Funding Opportunity Number (FON) PA-09-206. It supports small businesses developing improved tools and technologies related to cerebrospinal fluid (CSF) shunts used to treat hydrocephalus.

What is the main goal of the program?

The central goal is practical, product-oriented innovation that modernizes CSF shunt systems and related technologies in ways that measurably improve clinical care and patient outcomes in hydrocephalus. It is not described as a general basic science solicitation.

Is this opportunity focused on basic science or product development?

It is focused on enabling small companies to design, build, and validate improved shunt-related technologies that address real-world clinical limitations in current hydrocephalus treatment, rather than broadly supporting basic science research.

Which agency sponsors this opportunity?

The sponsoring agency is the National Institutes of Health (NIH).

What grant mechanisms are used?

The opportunity uses SBIR mechanisms R43/R44, which cover Phase I, Phase II, and Fast Track applications.

What does Phase I generally support under this FOA?

Phase I generally supports early feasibility efforts such as proof-of-concept demonstrations, prototype development, and initial performance testing.

What does Phase II generally support under this FOA?

Phase II generally supports more advanced research and development, including refinement, verification and validation activities, and steps that move a technology closer to clinical use and commercialization.

Is a Fast Track option available?

Yes. The FOA includes a Fast Track option for applicants proposing a streamlined path from Phase I into Phase II when the project rationale and development plan support an accelerated progression.

Who is eligible to apply?

Eligibility is limited to small business concerns.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement.

How does this SBIR opportunity relate to the STTR program?

This FOA runs in parallel with a scientifically identical companion announcement for the Small Business Technology Transfer (STTR) program: PA-09-205 (R41/R42). The SBIR track is described as being designed for projects primarily led by the small business, while STTR is structured around a required small business-research institution partnership.

If my project involves a formal research institution collaboration, should I consider STTR instead?

The FOA notes a companion STTR announcement that may be relevant for teams planning a formal collaboration with a research institution under STTR rules. The choice depends on how the team and work plan are organized (SBIR primarily small-business-led vs. STTR requiring a small business-research institution partnership).

What types of projects is NIH looking to support here?

NIH is looking to support research and development that can modernize shunt systems and related technologies for hydrocephalus treatment and address real-world clinical limitations, with an emphasis on practical development, validation, and movement toward clinical use and commercialization.

What category is this opportunity listed under?

The opportunity is categorized under Health, Income Security, and Social Services.

Which CFDA program numbers are associated with this opportunity?

The FOA is associated with CFDA program numbers 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and 93.865 (Child Health and Human Development Extramural Research).

Do the CFDA numbers suggest which NIH program areas are interested?

Yes. The associated CFDA numbers reflect NIH interests spanning neurological disorders and pediatric and developmental health needs, which are often affected by hydrocephalus.

How much funding is available and how many awards will be made?

Funding levels and the number of awards are not fixed in advance. Awards are contingent on the availability of appropriated funds and on receiving a sufficient number of high-quality, meritorious applications. NIH indicates that total dollars and the number of projects supported will vary depending on application quality, project duration, and proposed costs.

Is the award decision competitive?

Yes. The description emphasizes a competitive, peer-reviewed NIH process where strong scientific and technical merit, a credible development plan, and appropriate budget justification matter.

When was this FOA posted, and is it still open?

The FOA was posted on June 8, 2009. The original and final closing date was May 7, 2012, and it was archived on June 7, 2012, indicating it is no longer open.

Where was the full announcement published?

The full announcement was hosted through the NIH Grants Guide.

Is there a contact listed for help with the posting or access issues?

Yes. The notice references support contacts through the NIH Office of Extramural Research (OER) webmaster email for access or linking issues, which is intended for navigating the online posting rather than scientific questions.

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Previous opportunity: Advanced Tools and Technologies for Cerebrospinal Fluid Shunts STTR (R41/R42)

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