Opportunity Information: Apply for PA 09 205

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Advanced Tools and Technologies for Cerebrospinal Fluid Shunts STTR (R41/R42)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Jun 8, 2009 and posted on Jun 8, 2009.
  • Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses.
Apply for PA 09 205

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Opportunity Summary:

The Advanced Tools and Technologies for Cerebrospinal Fluid Shunts STTR (R41/R42) opportunity (Funding Opportunity Number PA-09-205) is a National Institutes of Health (NIH) discretionary grant program aimed at helping small business concerns create better, more advanced tools and technologies related to cerebrospinal fluid (CSF) shunts. The central goal is practical: support research and development that can improve the clinical treatment of patients living with hydrocephalus, a condition where CSF buildup can increase pressure in the brain and often requires shunt-based management. In other words, the focus is not basic science for its own sake, but innovation that can translate into safer, more effective, and more reliable shunt-related solutions used in real clinical settings.

This announcement uses the Small Business Technology Transfer (STTR) mechanism, specifically the R41/R42 pathways. That means it is structured to encourage formal collaboration between a qualifying small business and a nonprofit research institution (such as a university or hospital), with the intent of moving an idea from early feasibility work into more developed product-ready stages. Applicants can come in through Phase I (generally proof-of-concept and feasibility), Phase II (further development and validation), or the Fast-Track option that combines Phase I and Phase II into a single application designed to speed progress when the plan is well justified. The FOA also notes that it runs in parallel with a companion announcement of the same scientific scope for SBIR applicants (PA-09-206, using R43/R44). Practically, that parallel structure signals that NIH is trying to reach innovators who may be better suited to either STTR (with its required research partner structure) or SBIR (a slightly different small business research model), while keeping the technical goals consistent across both programs.

Eligibility is limited to small businesses, and there is no cost sharing or matching requirement, which reduces barriers for early-stage R&D groups that may not have substantial non-federal funds to contribute. The program falls under NIH funding activity areas tied to health, income security, and social services, and it is associated with CFDA numbers 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and 93.865 (Child Health and Human Development Extramural Research). That pairing reflects the real-world clinical footprint of hydrocephalus across ages, including pediatric populations, and the neurological complications and care needs that come with shunt dependency.

In terms of funding availability and award counts, NIH does not promise a fixed number of awards or a set-aside dollar total in the announcement text provided. Instead, it emphasizes that awards are contingent on the availability of funds and on receiving a sufficient number of high-quality, meritorious applications. The total dollars and number of awards ultimately depend on the proposed project scope, duration, budget, and scientific and technical merit, meaning applicants are competing both on innovation and on how convincingly they lay out a feasible development plan and cost structure.

Administratively, the opportunity was posted and created on June 8, 2009, with an original and final closing date of May 7, 2012, and an archive date of June 7, 2012. While it is archived now, the announcement remains useful as a reference point for how NIH frames shunt-technology priorities and how it expects small businesses to propose translational device or tool development work in this area. The listing also provides an NIH Office of Extramural Research (OER) contact path for technical issues accessing the full announcement and related links, pointing applicants to the NIH OER Webmaster email for support.

Frequently Asked Questions (FAQs)

What is this funding opportunity?

This is the Advanced Tools and Technologies for Cerebrospinal Fluid Shunts STTR (R41/R42) funding opportunity, Funding Opportunity Number (FON) PA-09-205. It is a National Institutes of Health (NIH) discretionary grant program focused on research and development (R&D) for improved tools and technologies related to cerebrospinal fluid (CSF) shunts.

What is the main goal of PA-09-205?

The central goal is to support practical, translational R&D that can improve the clinical treatment of patients living with hydrocephalus, where CSF buildup can increase pressure in the brain and often requires shunt-based management. The emphasis is on innovation that can translate into safer, more effective, and more reliable shunt-related solutions used in real clinical settings.

Is this opportunity focused on basic science or applied development?

Based on the description provided, the focus is not basic science for its own sake. It is aimed at innovation and development work that can move toward real-world clinical use for shunt-related technologies.

What funding mechanism does this opportunity use?

This announcement uses the Small Business Technology Transfer (STTR) mechanism, specifically the R41/R42 pathways.

What does STTR imply about how the project team must be structured?

The STTR structure is intended to encourage formal collaboration between a qualifying small business and a nonprofit research institution (for example, a university or hospital), with the intent of moving an idea from early feasibility work into more developed, product-ready stages.

What project phases can applicants apply for under R41/R42?

Applicants may apply through:

  • Phase I: generally proof-of-concept and feasibility work
  • Phase II: further development and validation
  • Fast-Track: a combined Phase I and Phase II application designed to speed progress when well justified

What is the Fast-Track option in this FOA?

The Fast-Track option combines Phase I and Phase II into a single application. It is intended to accelerate progress when the overall development plan is well supported and justified.

Who is eligible to apply?

Eligibility is limited to small business concerns. The STTR approach described also contemplates a formal collaboration with a nonprofit research institution (such as a university or hospital).

Is cost sharing or matching required?

No. The provided information states there is no cost sharing or matching requirement.

Is NIH guaranteeing a certain number of awards or a set amount of funding?

No. NIH does not promise a fixed number of awards or a set-aside total dollar amount in the information provided. Awards are contingent on the availability of funds and the receipt of a sufficient number of high-quality, meritorious applications.

What factors influence the number of awards and award size?

Based on the description provided, the total dollars and number of awards depend on the proposed project scope, duration, budget, and scientific/technical merit. Applicants are competing on both innovation and the feasibility of their development plan and cost structure.

Is there a related or companion funding opportunity?

Yes. The FOA runs in parallel with a companion announcement for SBIR applicants with the same scientific scope: PA-09-206 (using R43/R44).

How does the STTR opportunity relate to the SBIR companion announcement?

The parallel structure suggests NIH is trying to reach innovators who may be better suited to either STTR (with its required research partner structure) or SBIR (a different small business research model), while keeping the technical goals consistent across both programs.

Which NIH-related activity areas are associated with this program?

The program falls under NIH funding activity areas tied to health, income security, and social services, as described in the provided information.

What CFDA numbers are associated with this opportunity?

The opportunity is associated with CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and CFDA 93.865 (Child Health and Human Development Extramural Research).

Why are both neurosciences/neurological disorders and child health/HD mentioned?

The pairing is described as reflecting the real-world clinical footprint of hydrocephalus across ages, including pediatric populations, as well as the neurological complications and care needs associated with shunt dependency.

When was PA-09-205 posted, and what were the closing dates?

The opportunity was posted and created on June 8, 2009. The original and final closing date was May 7, 2012. The archive date was June 7, 2012.

Is this opportunity still open for applications?

No. Based on the dates provided and the note that it is archived, PA-09-205 is not currently open.

If it is archived, why does the announcement still matter?

Even though it is archived, the information is described as useful as a reference point for how NIH frames shunt-technology priorities and how it expects small businesses to propose translational device or tool development work in this area.

Where can applicants get help with technical issues accessing the full announcement and links?

The listing provides an NIH Office of Extramural Research (OER) contact path for technical issues and points users to the NIH OER Webmaster email for support.

Browse more opportunities from the same agency: National Institutes of Health

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Next opportunity: Advanced Tools and Technologies for Cerebrospinal Fluid Shunts SBIR (R43/R44)

Previous opportunity: Future Competitive Procurement for Community Based Prevention Initiative for Orphans and Vulnerable Children (OVC), Youth, and other Vulnerable Populations Program in Zambia

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