Opportunity Information: Apply for PA 07 395
Apply for PA 07 395
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders STTR (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.866 Aging Research.
- This funding opportunity was created on Jan 26, 2009 and posted on Jul 12, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Foreign institutions are not eligible to apply.
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Opportunity Summary:
The funding opportunity titled "Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders" (PA-07-395) is a National Institutes of Health (NIH) Small Business Technology Transfer (STTR) solicitation that supports small businesses working with research institutions to create next-generation tools and technologies aimed at improving clinical outcomes for patients receiving Deep Brain Stimulation (DBS). The core intent is translational and practical: it is not just about basic research on movement disorders, but about designing and developing tangible advances that can make DBS therapy safer, more effective, easier to deliver, or better tailored to individual patients.
This FOA uses the STTR R41/R42 mechanisms, meaning applicants can propose Phase I, Phase II, or a Fast-Track application that combines both phases in one submission. In the STTR structure, the small business is expected to partner formally with a nonprofit research institution (such as a university or hospital), with work meaningfully divided between the small business and the research partner in line with STTR requirements. The announcement also notes that it runs in parallel with an equivalent NIH solicitation under the SBIR program (PA-07-396, R43/R44) with the same scientific scope, giving small companies two closely related paths depending on whether they are pursuing the STTR (with a required research institution partner) or the SBIR structure.
The funding levels are clearly laid out by phase. For Phase I, applicants may request up to $250,000 in total costs per year for project periods of up to two years. For Phase II, applicants may request up to $500,000 in total costs per year for up to three years. These caps frame the expected scale of the work: Phase I is typically used to establish feasibility and produce convincing proof-of-concept data, while Phase II supports further development, refinement, validation, and steps toward readiness for real-world or clinical use. As with many NIH programs, awards depend on the availability of appropriated funds and on the submission of enough high-quality, competitive applications; in other words, even well-aligned projects are not guaranteed funding if budgets are tight or applications are not sufficiently strong.
From an applicant eligibility standpoint, the opportunity is aimed at small business concerns (SBCs) as defined under the STTR program rules. It explicitly states that foreign institutions are not eligible to apply, which generally means the applicant organization must be a qualifying U.S. small business, and the work must meet STTR location and performance requirements. The listing indicates no cost sharing or matching requirement, so applicants are not required to bring non-federal matching dollars as a condition of the award (though leveraging other resources can still strengthen a proposal in practice).
Administratively, the opportunity is categorized as a discretionary grant in the health funding area and is associated with several CFDA numbers reflecting NIH program alignments, including 93.853 (neurosciences and neurological disorders), 93.866 (aging research), 93.286 (technological innovations to improve human health), and 93.173 (research related to deafness and communication disorders). The posted date was July 12, 2007, with multiple receipt dates rather than one single deadline, indicating that NIH accepted applications on recurring cycles during the active period of the announcement. The archived date is May 6, 2010, meaning the specific FOA is no longer active, but it remains useful as a reference point for NIH interests and for locating successor opportunities that cover similar DBS technology development goals.
Overall, this FOA is best understood as an NIH-backed product development and translational engineering opportunity focused on DBS for movement disorders, using the STTR model to pair small business development capacity with academic or clinical research expertise. Applicants are expected to propose development work that plausibly leads to improved DBS treatment in clinical settings, and to use the phased STTR structure to move from feasibility to more mature, validated technology ready for downstream commercialization and clinical adoption.
Frequently Asked Questions (FAQs): Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders (PA-07-395)
What is the title and identifier of this funding opportunity?
The opportunity is titled "Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders" and is identified as PA-07-395.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of program is this (STTR or SBIR)?
This solicitation is an NIH Small Business Technology Transfer (STTR) opportunity.
What is the overall purpose of this FOA?
The core purpose is to support small businesses working with research institutions to create next-generation tools and technologies that can improve clinical outcomes for patients receiving Deep Brain Stimulation (DBS) for movement disorders. The focus is translational and practical, emphasizing tangible advances that can make DBS safer, more effective, easier to deliver, or more individualized.
Is this opportunity focused on basic research or product/technology development?
It is primarily focused on translational, practical technology development rather than basic research alone. Proposed work is expected to lead toward real-world tools or technologies that improve DBS therapy in clinical settings.
What grant mechanisms are used under this FOA?
This FOA uses the NIH STTR R41/R42 mechanisms.
Can applicants submit Phase I, Phase II, or Fast-Track applications?
Yes. Applicants may propose Phase I, Phase II, or a Fast-Track application that combines both phases into a single submission.
What is the STTR partnership requirement?
Under STTR, the small business is expected to formally partner with a nonprofit research institution (such as a university or hospital), with work meaningfully divided between the small business and the research partner in line with STTR requirements.
Is there a related SBIR opportunity with similar scope?
Yes. This STTR FOA runs in parallel with an equivalent NIH solicitation under the SBIR program: PA-07-396 (R43/R44), with the same scientific scope. Companies could consider which path fits their situation, depending on whether they want/need the STTR structure (which requires a research institution partner) or the SBIR structure.
How much funding is available for Phase I?
For Phase I, applicants may request up to $250,000 in total costs per year, for project periods of up to two years.
How much funding is available for Phase II?
For Phase II, applicants may request up to $500,000 in total costs per year, for project periods of up to three years.
What is Phase I generally expected to accomplish?
Phase I is generally used to establish feasibility and produce convincing proof-of-concept results aligned with developing improved DBS-related tools or technologies.
What is Phase II generally expected to support?
Phase II generally supports further development, refinement, validation, and steps toward readiness for real-world or clinical use.
Is funding guaranteed if a project fits the topic area?
No. Awards depend on the availability of appropriated funds and the submission of enough high-quality, competitive applications. A well-aligned project is not guaranteed funding if budgets are tight or applications are not sufficiently strong.
Who is eligible to apply?
The opportunity is aimed at small business concerns (SBCs) as defined under STTR program rules.
Are foreign institutions eligible to apply?
No. The FOA explicitly states that foreign institutions are not eligible to apply. In practice, the applicant organization must be a qualifying U.S. small business, and the work must meet STTR location and performance requirements.
Is cost sharing or matching required?
No. The listing indicates no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of the award.
How is this opportunity categorized from a funding standpoint?
It is categorized as a discretionary grant in the health funding area.
Which CFDA numbers are associated with this FOA?
This FOA is associated with multiple CFDA numbers reflecting NIH program alignments, including:
- 93.853 (neurosciences and neurological disorders)
- 93.866 (aging research)
- 93.286 (technological innovations to improve human health)
- 93.173 (research related to deafness and communication disorders)
When was this FOA posted?
The posted date is July 12, 2007.
Did this FOA have a single deadline?
No. It had multiple receipt dates rather than one single deadline, indicating NIH accepted applications on recurring cycles during the active period of the announcement.
Is this FOA still active?
No. The archived date is May 6, 2010, which means this specific FOA is no longer active.
If the FOA is archived, why is it still useful?
Even though it is no longer active, it can still be useful as a reference point for NIH interests and for locating successor opportunities that support similar DBS technology development goals.
What types of outcomes is NIH trying to encourage through this FOA?
The FOA emphasizes development of tools and technologies that plausibly lead to improved DBS treatment in clinical settings, such as advances that make DBS safer, more effective, easier to deliver, or better tailored to individual patients.
What is the general theme of the work expected under this program?
This FOA is best understood as an NIH-backed product development and translational engineering opportunity focused on DBS for movement disorders, using the STTR model to combine small business development capability with academic or clinical research expertise.
Browse more opportunities from the same category: Health
Next opportunity: Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders SBIR (R43/R44)
Previous opportunity: Neurotechnology Research, Development, and Enhancement (STTR R41/R42)
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