Opportunity Information: Apply for PA 10 176
Apply for PA 10 176
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Advanced Tools and Technologies for Deep Brain Stimulation (SBIR R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Apr 27, 2010 and posted on Apr 27, 2010.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The Advanced Tools and Technologies for Deep Brain Stimulation (SBIR R43/R44) opportunity (Funding Opportunity Number PA 10 176) is a National Institutes of Health (NIH) Funding Opportunity Announcement designed to push forward new, practical innovations that can improve how Deep Brain Stimulation (DBS) is delivered in real clinical settings. The main aim is to motivate small business concerns to create and develop next-generation tools and technologies that make DBS treatment better for patients, whether that means safer procedures, more precise targeting, better device performance, improved programming and monitoring, or other technology-driven advances that translate into meaningful clinical benefit. In plain terms, the government is signaling that DBS is an important therapy area and that there is room for smarter, more advanced technology that can improve outcomes and day-to-day care.
This program uses the SBIR grant mechanism, specifically the R43/R44 structure, which supports phased development. Applicants can propose Phase I projects (generally focused on early feasibility, proof-of-concept, and prototype groundwork), Phase II projects (typically emphasizing further development, refinement, and stronger validation as the product moves toward real-world use), or a Fast Track submission that links Phase I and Phase II into a single, continuous application pathway. The FOA is run in parallel with a companion announcement with the same scientific scope for the STTR program (PA 10 175, using R41/R42), which is relevant if a company prefers a structure that formally centers collaboration with a research institution. For this SBIR version, the core point is that a small business is positioned as the lead driver of innovation and product development.
From a funding and award perspective, the announcement does not promise a fixed number of awards or a guaranteed funding pool. Instead, NIH makes clear that awards depend on two things: whether funds are available and whether enough high-quality, competitive applications are submitted. The total dollars and number of awards will vary based on the merit of proposals, the length of proposed work, and the budgets requested. That framing is common for NIH technology-development announcements: strong projects can be funded, but nothing is automatic, and budgets and timelines are evaluated in the context of significance, feasibility, and likely impact.
Eligibility is limited to small businesses, and there is no cost sharing or matching requirement, meaning applicants are not required to bring non-federal matching funds to participate. The opportunity is categorized as a discretionary grant within the Health area (listed under Health; Income Security and Social Services as the funding activity category) and is associated with multiple CFDA program areas, reflecting that DBS technology development can intersect with several NIH missions. The CFDA numbers listed include 93.173 (Research Related to Deafness and Communication Disorders), 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health), 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders), 93.865 (Child Health and Human Development Extramural Research), and 93.866 (Aging Research). That spread suggests NIH anticipated applications that could touch neurological disorders broadly, technology innovation, and patient populations spanning from pediatrics to older adults, depending on the DBS indication and the tool being developed.
In terms of timing and status, the FOA was posted and created on April 27, 2010, with an original and final closing date of May 7, 2013. It was archived on June 7, 2013, which means it is no longer an active solicitation, but it remains useful as a reference for the kind of DBS-focused technology development NIH has historically sought to support through SBIR. The official NIH information page was provided through the NIH Grants Guide (http://grants.nih.gov/grants/guide/pa-files/PA-10-176.html), and the contact listed for access or technical linking issues was the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
Overall, this opportunity can be understood as a targeted government push to strengthen the DBS technology ecosystem by funding small companies to build better instruments, devices, software, or other enabling technologies that can translate into improved DBS clinical treatment. The focus is not basic science for its own sake, but development-oriented innovation with a clear line of sight to practical clinical improvement for DBS patients.
Frequently Asked Questions (FAQs)
What is the "Advanced Tools and Technologies for Deep Brain Stimulation (SBIR R43/R44)" opportunity?
It is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) intended to support small businesses developing new and practical tools and technologies that improve how Deep Brain Stimulation (DBS) is delivered in real clinical settings. The FOA number is PA 10 176.
What is the main goal of this FOA?
The main goal is to motivate small business concerns to create next-generation DBS tools and technologies that translate into meaningful clinical benefit, such as safer procedures, more precise targeting, better device performance, and improved programming and monitoring.
What types of innovations does NIH want to see under this announcement?
The announcement emphasizes development-oriented innovation that can improve DBS in practice. Examples mentioned include advances that make procedures safer, targeting more precise, device performance stronger, and programming/monitoring better, as well as other technology-driven improvements that support day-to-day DBS care and outcomes.
Is this funding focused on basic science or product-oriented development?
This FOA is framed as development-oriented. It is focused on practical innovations with a clear line of sight to improving DBS clinical treatment rather than basic science for its own sake.
What funding mechanism does this opportunity use?
It uses the SBIR grant mechanism, specifically the R43/R44 structure, which supports phased development.
What are Phase I and Phase II in the SBIR R43/R44 structure?
Phase I is generally focused on early feasibility, proof-of-concept work, and prototype groundwork. Phase II typically emphasizes further development, refinement, and stronger validation as the product moves closer to real-world use.
What is a Fast Track submission?
A Fast Track submission links Phase I and Phase II into a single, continuous application pathway under the SBIR structure described in the announcement.
Is there a related STTR announcement for the same scientific scope?
Yes. This SBIR FOA (PA 10 176) is run in parallel with a companion announcement with the same scientific scope for the STTR program: PA 10 175, using the R41/R42 mechanism.
How does the SBIR version position the applicant compared to STTR?
For this SBIR version, the small business is positioned as the lead driver of innovation and product development. The companion STTR version is noted as relevant if a company prefers a structure that formally centers collaboration with a research institution.
Who is eligible to apply?
Eligibility is limited to small businesses (small business concerns).
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement, meaning applicants are not required to bring non-federal matching funds to participate.
Does NIH guarantee a set number of awards or a fixed funding pool for this FOA?
No. The announcement does not promise a fixed number of awards or a guaranteed funding pool. NIH indicates awards depend on the availability of funds and the submission of enough high-quality, competitive applications.
What determines the total dollars awarded and the number of awards made?
The total dollars and number of awards can vary based on the merit of proposals, the length of the proposed work, and the budgets requested, along with NIH considerations such as significance, feasibility, and likely impact.
What is the funding activity/category described for this opportunity?
It is described as a discretionary grant within the Health area, listed under the funding activity category "Health; Income Security and Social Services."
Which CFDA program areas are associated with this FOA?
The CFDA numbers listed are 93.173 (Research Related to Deafness and Communication Disorders), 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health), 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders), 93.865 (Child Health and Human Development Extramural Research), and 93.866 (Aging Research).
What does it mean that multiple CFDA numbers are listed?
It suggests NIH anticipated DBS technology development proposals could intersect with multiple NIH missions, including neurological disorders and technology innovation, and could relate to different patient populations (from pediatrics to older adults) depending on the DBS indication and the tool being developed.
When was this FOA posted and when did it close?
The FOA was posted and created on April 27, 2010. Its original and final closing date was May 7, 2013.
Is this FOA currently active?
No. It was archived on June 7, 2013, meaning it is no longer an active solicitation. It may still be useful as a reference for the types of DBS-focused technology development NIH has supported historically through SBIR.
Where can I find the official NIH listing for this FOA?
The official NIH information page was provided through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-10-176.html.
Who was listed as the contact for access or technical linking issues?
The contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
In simple terms, what is the government signaling through this opportunity?
The FOA signals that DBS is an important therapy area and that NIH sees room for smarter, more advanced technology that can improve clinical outcomes and the day-to-day delivery of DBS care.
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