Opportunity Information: Apply for PA 16 159
Apply for PA 16 159
- The HHS-NIH11 in the food and nutrition, health sector is offering a public funding opportunity titled "Advances in Polycystic Kidney Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847,.
- This funding opportunity was created on Mar 30, 2016 and posted on Mar 30, 2016.
- Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
Advances in Polycystic Kidney Disease (R01) (Funding Opportunity Number PA 16-159) is a National Institutes of Health (NIH) discretionary grant opportunity administered under HHS-NIH (listed as HHS-NIH11). It uses the R01 research project grant mechanism, which is NIH's main vehicle for supporting hypothesis-driven, investigator-initiated research. The announcement was posted and created on March 30, 2016, with an application closing date of May 7, 2019.
The central goal of the opportunity is to stimulate and expand researcher engagement in both basic and applied studies focused on Polycystic Kidney Disease (PKD). The FOA specifically highlights interest in understanding the etiology (the underlying causes and origins) and the pathogenesis (the biological mechanisms and progression) of PKD across its two major inherited forms: autosomal dominant PKD (ADPKD) and autosomal recessive PKD (ARPKD). In practical terms, the program is looking for research that clarifies how and why PKD develops, what molecular or cellular pathways drive cyst formation and kidney damage, and what factors influence disease severity, progression, and complications.
Although the FOA emphasizes discovery and mechanistic work, it also explicitly encourages applied investigations, meaning studies that translate biological insights toward practical use. The stated long-term aim is to build a stronger scientific foundation for new therapeutic approaches. That can include identifying targets for drug development, validating pathways that could be modulated to slow cyst growth or preserve kidney function, and generating evidence that supports future preclinical or clinically oriented interventions. The throughline is that projects should contribute in a meaningful way to the pipeline from understanding disease biology to enabling better treatments.
Eligibility is broad and includes a wide range of public, private, nonprofit, and governmental entities. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations other than small businesses; small businesses; and Native American tribal governments (federally recognized) as well as other tribal organizations. Public housing authorities and Indian housing authorities are also listed as eligible. The opportunity also includes an "Others" category, with a note to consult the additional eligibility details in the full FOA text for any clarifications or special conditions.
The program is categorized under the broader activity areas of health (and is also tagged with food and nutrition in the provided classification fields) and is associated with CFDA numbers 93.847 (and 93.846 in the listing). The source information provided does not specify an award ceiling, the expected number of awards, or other budgetary totals, so applicants would typically refer to the full NIH FOA documentation and standard R01 policies for typical budget structures, project periods, and review considerations.
Overall, this FOA is designed to strengthen the PKD research landscape by encouraging robust, R01-level projects that deepen understanding of disease cause and mechanism in both dominant and recessive PKD, with a clear emphasis on generating knowledge that can be leveraged into new or improved therapeutic strategies over time.
Frequently Asked Questions (FAQs) - Advances in Polycystic Kidney Disease (R01) (PA 16-159)
What is the name of this funding opportunity?
The opportunity is titled Advances in Polycystic Kidney Disease (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA 16-159.
Which agency is offering and administering this grant?
This is a National Institutes of Health (NIH) discretionary grant opportunity administered under HHS-NIH (listed as HHS-NIH11).
What type of grant mechanism does this opportunity use?
This opportunity uses the R01 research project grant mechanism, which is NIH's main vehicle for supporting hypothesis-driven, investigator-initiated research.
What is the main goal of this FOA?
The central goal is to stimulate and expand researcher engagement in both basic and applied studies focused on Polycystic Kidney Disease (PKD).
What specific PKD topics is the FOA interested in?
The FOA specifically highlights interest in understanding the etiology (underlying causes and origins) and the pathogenesis (biological mechanisms and progression) of PKD.
Which forms of Polycystic Kidney Disease are within scope?
The FOA covers PKD across its two major inherited forms: autosomal dominant PKD (ADPKD) and autosomal recessive PKD (ARPKD).
What kinds of scientific questions does this FOA want to address?
Based on the description provided, the program is looking for research that clarifies how and why PKD develops, what molecular or cellular pathways drive cyst formation and kidney damage, and what factors influence disease severity, progression, and complications.
Is this FOA only for basic science, or does it support applied and translational work too?
It supports both. While the FOA emphasizes discovery and mechanistic work, it also explicitly encourages applied investigations that translate biological insights toward practical use.
What is the long-term aim of the research supported by this FOA?
The stated long-term aim is to build a stronger scientific foundation for new therapeutic approaches for PKD.
How does this FOA connect research to future treatments?
The throughline described is that projects should contribute meaningfully to the pipeline from understanding disease biology to enabling better treatments. Examples mentioned include identifying targets for drug development, validating pathways that could be modulated to slow cyst growth or preserve kidney function, and generating evidence that supports future preclinical or clinically oriented interventions.
Who is eligible to apply?
Eligibility is broad and includes many types of public, private, nonprofit, and governmental entities.
Are state and local government entities eligible?
Yes. Eligible applicants include state governments, county governments, and city or township governments.
Are special district governments eligible?
Yes. Special district governments are listed as eligible applicants.
Are school districts eligible?
Yes. Independent school districts are listed as eligible applicants.
Are universities and colleges eligible?
Yes. Eligibility includes both public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories as stated in the listing).
Are for-profit organizations eligible?
Yes. Eligibility includes for-profit organizations other than small businesses as well as small businesses.
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants include Native American tribal governments (federally recognized) and other tribal organizations.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible.
What does the "Others" eligibility category mean?
The opportunity includes an "Others" category with a note to consult the additional eligibility details in the full FOA text for clarifications or special conditions.
When was this FOA posted and created?
The announcement was posted and created on March 30, 2016.
What was the application closing date?
The application closing date listed is May 7, 2019.
What is the activity area for this opportunity?
The program is categorized under the broader activity areas of health and is also tagged with food and nutrition in the provided classification fields.
What CFDA numbers are associated with this FOA?
This opportunity is associated with CFDA number 93.847, and it is also listed with 93.846 in the source listing.
Does the provided information include an award ceiling or expected number of awards?
No. The source information provided does not specify an award ceiling, the expected number of awards, or other overall budgetary totals.
Where should applicants look for budget structure and typical project period expectations?
Based on the information provided, applicants would typically refer to the full NIH FOA documentation and standard R01 policies for typical budget structures, project periods, and review considerations.
In one sentence, what is this FOA designed to do?
It is designed to strengthen the PKD research landscape by encouraging robust, R01-level projects that deepen understanding of disease cause and mechanism in both ADPKD and ARPKD, with an emphasis on generating knowledge that can support new or improved therapeutic strategies over time.
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| Human Islet Distribution Coordinating Center (UC4) Apply for RFA DK 16 023 Funding Number: RFA DK 16 023 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $1,300,000 |
| Limited Competition: Rare Diseases Clinical Research Network (RDCRN) Project Supplements for Clinical Trials to Repurpose Drugs in Collaboration with E-Rare Awardees (Admin Supp) Apply for PA 16 183 Funding Number: PA 16 183 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Short-Term Research Experience Program for Underrepresented Persons (STEP-UP) (R25) Apply for RFA DK 16 021 Funding Number: RFA DK 16 021 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Mentored Research Scientist Development Award (K01) Apply for PAR 16 211 Funding Number: PAR 16 211 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Nutrition Obesity Research Centers (NORCs) (P30) Apply for RFA DK 16 006 Funding Number: RFA DK 16 006 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Standardization of C-peptide and HbA1c Measurements Program (UC4) Apply for RFA DK 16 011 Funding Number: RFA DK 16 011 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Diabetes Research Centers (P30) Apply for RFA DK 16 020 Funding Number: RFA DK 16 020 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Ancillary Studies to Identify Behavioral and/or Psychological Phenotypes Contributing to Obesity (R01) Apply for PAR 16 304 Funding Number: PAR 16 304 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Collaborative Islet Transplantation Registry (UC4) Apply for RFA DK 16 503 Funding Number: RFA DK 16 503 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Neurocognitive Effects of Glycemic Dysregulation in Type 1 Diabetes (DP3) Apply for RFA DK 16 007 Funding Number: RFA DK 16 007 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $3,000,000 |
| Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01) Apply for PAR 16 333 Funding Number: PAR 16 333 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pediatric Centers of Excellence in Nephrology (P50) Apply for RFA DK 16 032 Funding Number: RFA DK 16 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| George M. O'Brien Kidney Research Core Centers (P30) Apply for RFA DK 16 031 Funding Number: RFA DK 16 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Promoting Organ and Tissue Donation Among Diverse Populations (R01) Apply for RFA DK 16 022 Funding Number: RFA DK 16 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24) Apply for RFA DK 16 510 Funding Number: RFA DK 16 510 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,062,000 |
| NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genetic Research Centers (GRCs) (U01) Apply for RFA DK 16 029 Funding Number: RFA DK 16 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $293,000 |
| Coordinating Unit for the Mouse Metabolic Phenotyping Centers (U24) Apply for RFA DK 16 034 Funding Number: RFA DK 16 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,212,563 |
| Coordinating Unit for Diabetic Complications Consortium (U24) Apply for RFA DK 16 036 Funding Number: RFA DK 16 036 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $3,122,000 |
| APOL1 Long-term Kidney Transplantation Outcomes Network Scientific and Data Research Center (APOLLO SDRC) (Collaborative U01) Apply for RFA DK 16 024 Funding Number: RFA DK 16 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Limited Competition: Data Coordinating Center for Type 1 Diabetes TrialNet (UC4) Apply for RFA DK 16 505 Funding Number: RFA DK 16 505 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $45,000,000 |
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