Opportunity Information: Apply for PA 14 133
Apply for PA 14 133
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Advancing Structural Level Interventions Through Enhanced Understanding of Social Determinants in HIV Prevention and Care (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Feb 28, 2014 and posted on Feb 28, 2014.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses City or township governments Private institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity PA-14-133, titled "Advancing Structural Level Interventions Through Enhanced Understanding of Social Determinants in HIV Prevention and Care (R01)," supports research that digs into how social and structural conditions shape HIV risk, prevention, and treatment outcomes, and then uses that knowledge to design and test interventions that operate at a structural level. The core idea is that HIV outcomes are not driven only by individual behavior or clinical care, but also by upstream factors like housing stability, poverty, stigma, discrimination, incarceration, education, employment, immigration-related barriers, neighborhood conditions, and access to health services. The FOA is specifically interested in how these social determinants contribute to inequities, meaning differences in HIV risk or disease outcomes that track with race/ethnicity, socioeconomic status, geography, gender identity, sexual orientation, or other marginalized statuses. Projects are expected to produce actionable insights that can improve both HIV prevention efforts (such as reducing new infections) and HIV care outcomes (such as linkage to care, retention, and viral suppression).
The announcement describes two research directions that can be pursued separately or together. One direction focuses on characterizing which social determinants matter most for HIV prevention and treatment, how they interact, and how they generate or reinforce disparities. This can include identifying the pathways through which structural forces affect HIV outcomes, measuring the size of their effects, and clarifying which populations and settings are most impacted. The second direction emphasizes developing and testing structural interventions, meaning approaches that change policies, institutional practices, service delivery systems, or environmental conditions rather than relying only on individual-level education or counseling. The intent is to reduce the harmful effects of negative determinants (for example, barriers created by criminalization, unstable housing, or lack of access to care) or to strengthen positive determinants (such as supportive community infrastructure, improved service integration, or protective policies). Competitive applications under this FOA would typically connect a clearly defined social determinant to a concrete intervention strategy and specify outcomes tied to HIV prevention or the HIV care continuum.
This is an R01 grant mechanism, placing it in the category of full-scale research projects, usually suited for well-developed studies with strong conceptual frameworks, rigorous methods, and clear plans for analysis and evaluation. The funding instrument is a discretionary grant under the health activity category, and it is associated with CFDA program areas including Mental Health Research Grants (93.242), Allergy and Infectious Diseases Research (93.855), and Microbiology and Infectious Diseases Research (93.856), reflecting the cross-cutting nature of HIV research across behavioral, social, mental health, and biomedical domains. The FOA indicates there is no cost sharing or matching requirement, which reduces barriers for applicants and allows budgets to be driven by the scientific needs of the project.
Eligibility is broad and inclusive, reflecting NIH's interest in drawing proposals from many kinds of organizations that are positioned to study and address structural drivers of HIV. Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses), state and local governments (including counties, cities, townships, special districts), independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes a wide range of mission-focused and underserved-serving institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, as well as faith-based and community-based organizations. Federal agencies and regional organizations may also be eligible. Importantly, non-U.S. entities and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy, which signals an openness to international perspectives and global learning where relevant to HIV structural determinants.
Administrative details indicate the FOA was posted and created on February 28, 2014, with an original and final closing date of January 7, 2017, and an archive date of February 7, 2017, meaning it was active during that period and is now closed. The sponsoring agency is the National Institutes of Health, and the full announcement was provided through the NIH Grants Guide (linked in the FOA). For technical issues accessing the announcement or linking problems, the point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PA-14-133 is aimed at shifting HIV research and intervention design toward upstream, real-world conditions that shape health, with a strong focus on understanding and reducing inequities. It supports both foundational research that clarifies which social determinants are most influential and intervention research that tests structural solutions capable of producing measurable improvements in HIV prevention and care outcomes.
Frequently Asked Questions (FAQs) - NIH PA-14-133 (R01)
What is the NIH funding opportunity PA-14-133?
PA-14-133 is an NIH Funding Opportunity Announcement titled "Advancing Structural Level Interventions Through Enhanced Understanding of Social Determinants in HIV Prevention and Care (R01)." It supported research on how social and structural conditions shape HIV risk, prevention, and treatment outcomes, and how that evidence can be used to design and test structural-level interventions.
What is the main purpose of this FOA?
The purpose was to move HIV research beyond a focus on individual behavior or clinical care alone by examining upstream social determinants (such as housing stability, poverty, stigma, discrimination, incarceration, education, employment, immigration-related barriers, neighborhood conditions, and access to health services) and using that understanding to improve HIV prevention and HIV care outcomes.
What kinds of HIV outcomes was the FOA trying to improve?
The FOA emphasized actionable insights that could strengthen HIV prevention (for example, reducing new infections) and improve HIV care outcomes, including steps along the HIV care continuum such as linkage to care, retention in care, and viral suppression.
What does the FOA mean by "social determinants" and "structural conditions"?
In this announcement, social determinants and structural conditions refer to upstream factors that shape health and health care access. Examples named in the FOA include housing stability, poverty, stigma and discrimination, incarceration, education, employment, immigration-related barriers, neighborhood conditions, and access to health services.
How does the FOA define "structural interventions"?
Structural interventions are approaches that change policies, institutional practices, service delivery systems, or environmental conditions, rather than relying only on individual-level education or counseling. The intent is to reduce harmful effects of negative determinants or strengthen positive determinants that support prevention and care.
What are the two research directions described in the FOA?
The FOA described two directions that could be pursued separately or together: (1) characterizing which social determinants matter most, how they interact, and how they generate or reinforce disparities; and (2) developing and testing structural interventions designed to change upstream conditions and improve HIV prevention and care outcomes.
What types of questions fit the first research direction (characterizing determinants)?
This direction included identifying which determinants have the strongest influence on HIV prevention and treatment outcomes, mapping pathways through which structural forces affect HIV outcomes, measuring the size of their effects, and clarifying which populations and settings are most impacted.
What types of projects fit the second research direction (testing interventions)?
This direction focused on designing and testing interventions that operate structurally by changing policies, institutions, systems, or environments. The FOA highlighted efforts that reduce barriers created by factors like criminalization, unstable housing, or lack of access to care, or that strengthen positive determinants such as supportive community infrastructure, improved service integration, or protective policies.
What makes an application "competitive" under this FOA?
Based on the FOA description, competitive applications would typically link a clearly defined social determinant to a concrete structural intervention strategy and specify measurable outcomes tied to HIV prevention or the HIV care continuum.
How is the FOA connected to health inequities and disparities?
The FOA explicitly focused on inequities in HIV risk or disease outcomes that track with race/ethnicity, socioeconomic status, geography, gender identity, sexual orientation, or other marginalized statuses. It sought research that explains how social determinants contribute to disparities and how structural approaches can reduce them.
What grant mechanism does PA-14-133 use?
PA-14-133 used the R01 mechanism, which is typically used for full-scale research projects and is generally suited for well-developed studies with strong conceptual frameworks, rigorous methods, and clear plans for analysis and evaluation.
What type of funding instrument is this opportunity?
The FOA described the award as a discretionary grant under the health activity category.
Are there any cost sharing or matching requirements?
No. The FOA indicated there was no cost sharing or matching requirement, allowing the project budget to be driven by scientific needs rather than a required match.
Which CFDA program areas are associated with this FOA?
The FOA was associated with CFDA program areas including Mental Health Research Grants (93.242), Allergy and Infectious Diseases Research (93.855), and Microbiology and Infectious Diseases Research (93.856), reflecting HIV research spanning behavioral, social, mental health, and biomedical domains.
Who was eligible to apply?
Eligibility was broad. The FOA listed eligible applicants such as public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses), and state and local governments (including counties, cities, townships, special districts). It also included independent school districts and public housing authorities/Indian housing authorities.
Did the FOA encourage applications from specific types of institutions or organizations?
Yes. The FOA explicitly included a wide range of mission-focused and underserved-serving institutions and organizations, including HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, as well as faith-based and community-based organizations.
Could government entities apply?
Yes. State and local governments were listed as eligible, including counties, cities, townships, special districts, and other listed government-related entities such as public housing authorities/Indian housing authorities.
Were for-profit organizations allowed to apply?
Yes. For-profit organizations, including small businesses, were included among eligible applicants.
Were federal agencies or regional organizations eligible?
Yes. The FOA stated that federal agencies and regional organizations may also be eligible.
Could non-U.S. or foreign institutions apply?
Yes. The FOA stated that non-U.S. entities and foreign institutions were eligible to apply. It also allowed non-U.S. components of U.S. organizations and foreign components as defined by NIH policy.
Is this funding opportunity still open?
No. The FOA information indicates it was created and posted on February 28, 2014, had an original and final closing date of January 7, 2017, and an archive date of February 7, 2017. That means it was active during that period and is now closed.
Who sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
Where was the full announcement published?
The full announcement was provided through the NIH Grants Guide, as referenced in the FOA description.
Who should be contacted for technical issues with the announcement link or access?
For technical issues accessing the announcement or problems with linking, the FOA listed the NIH Office of Extramural Research (OER) Webmaster as the contact: FBOWebmaster@OD.NIH.GOV.
Does the FOA require focusing only on individual-level interventions like counseling or education?
No. The FOA emphasized structural interventions that change policies, institutions, systems, or environments, rather than relying only on individual-level education or counseling.
Can a project combine both studying determinants and testing an intervention?
Yes. The FOA stated that the two research directions (characterizing determinants and developing/testing structural interventions) could be pursued separately or together.
Browse more opportunities from the same category: Health
Next opportunity: Advancing Structural Level Interventions Through Enhanced Understanding of Social Determinants in HIV Prevention and Care (R21)
Previous opportunity: Accelerating Improvements in the HIV Care Continuum (R01)
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