Opportunity Information: Apply for RFA HS 12 007
Apply for RFA HS 12 007
- The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes.
- This funding opportunity was created on Jun 1, 2012 and posted on Jun 1, 2012.
- Applicants must submit their applications by Jul 31, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Faith based or Community based Organizations Indian/Native American Tribal Governments (Other than Federally Recognized) AHRQs authorizing legislation does not allow for profit organizations to be eligible to lead applications under this research mechanism. For profit organizations may participate in projects as members of consortia or as subcontractors only. Because the purpose of this program is to improve healthcare in the United States, foreign institutions may participate in projects as members of consortia or as subcontractors only. Applications submitted by for profit organizations or foreign institutions will not be reviewed. Organizations described in section 501(c) 4 of the Internal Revenue Code that engage in lobbying are not eligible. HHS grants policy requires that the grant recipient perform a substantive role in the conduct of the planned project or program activity and not merely serve as a conduit of funds to another party or parties. If consortium/contractual activities represent a significant portion of the overall project, the applicant must justify why the applicant organization, rather than the party(s) performing this portion of the overall project, should be the grantee and what substantive role the applicant organization will play. Justification can be provided in the Specific Aims or Research Strategy section of the PHS398 Research Plan Component sections of the SF424 (R and R) application. There is no budget allocation guideline for determining substantial involvement determination of substantial involvement is based on a review of the primary project activities for which grant support is provided and the organization(s) that will be performing those activities.
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Opportunity Summary:
The AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00), Funding Opportunity Number RFA-HS-12-007, is a discretionary grant program from the Agency for Healthcare Research and Quality (AHRQ) intended to build and sustain a pipeline of early-career investigators who can become independent leaders in patient-centered outcomes research and comparative effectiveness methods. At its core, the opportunity is about career development: it supports promising researchers while they are still in a mentored postdoctoral phase and then helps them move, on a defined timeline, into an independent research role where they can secure and lead their own AHRQ or other independent research funding. The larger policy goal is to strengthen the national capacity to conduct rigorous studies that evaluate what works best for patients in real-world health care, focusing on outcomes, quality, and value.
The program uses the well-known two-stage K99/R00 structure. The first phase (K99) supports a mentored, postdoctoral research period focused on developing advanced skills and expertise, particularly in comparative effectiveness and related PCOR methods. This is meant to be a period of intensive training, methodological growth, and broadening of interdisciplinary perspectives, so that awardees are not only capable analysts but can also design, execute, and interpret complex outcomes research that is relevant to patient care and health system decision-making. The second phase (R00) supports the transition to independence, providing resources once the investigator secures a stable, independent research position. The intent is that the candidate emerges from the K99 phase positioned to compete successfully for independent research support and to establish a clear research direction as an independent investigator.
From a funding and scale perspective, the announcement projected about 10 awards, with an estimated total program funding level of $4,500,000. The associated CFDA number listed is 93.226 (Research on Healthcare Costs, Quality and Outcomes). There is no cost sharing or matching requirement, which generally simplifies budgeting for applicants and sponsoring institutions. The opportunity was posted on June 1, 2012, with an original and final application closing date of July 31, 2012, and it was archived on August 31, 2012, meaning it was a time-limited solicitation rather than an open-ended standing program announcement.
Eligibility is structured primarily around U.S.-based public and nonprofit entities that can legitimately host and support the proposed training-to-independence pathway. Eligible applicants include state governments; public and state-controlled institutions of higher education; federally recognized Native American tribal governments; and other tribal organizations. The announcement also notes that other eligible applicants may include faith-based or community-based organizations, as long as they meet the relevant requirements. Importantly, AHRQ’s authorizing legislation does not allow for-profit organizations to serve as the lead applicant under this mechanism. For-profit entities can still be involved, but only as consortium partners or subcontractors. Similarly, foreign institutions are not eligible to apply as the primary applicant; they may participate only through consortium or subcontract relationships, reflecting the program’s emphasis on improving health care in the United States. The announcement also excludes certain organizations, including entities described in section 501(c)(4) of the Internal Revenue Code that engage in lobbying.
The solicitation also emphasizes that the award recipient organization must play a substantive, meaningful role in carrying out the work, rather than functioning primarily as a pass-through for funds. If a large portion of the work is being done through consortium or contracted arrangements, the applicant organization is expected to justify why it should be the grantee and clearly describe what it will do directly. This is a governance and accountability point that affects how applicants structure collaborations and how they explain institutional roles in the research plan. Rather than using a strict budget percentage to define “substantive involvement,†AHRQ indicates that it will evaluate involvement based on the nature of the primary project activities and which organizations are performing them.
Overall, this opportunity is best understood as a structured career-launch mechanism for postdoctoral researchers who want to specialize in PCOR and comparative effectiveness research, with the explicit aim of helping them move quickly from mentorship to independence. It is designed to expand the field by investing early in investigators’ methodological skills and interdisciplinary capacity, while also pushing toward the end goal of stable, independent research positions and future externally supported research programs. For full details, the announcement directs applicants to the NIH Grants Guide posting (RFA-HS-12-007) and provides NIH Office of Extramural Research (OER) webmaster contacts for technical access issues.
FAQs: AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00) - RFA-HS-12-007
What is this funding opportunity?
This is the AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00), Funding Opportunity Number RFA-HS-12-007. It is a discretionary grant program from the Agency for Healthcare Research and Quality (AHRQ).
What is the main purpose of the award?
The main purpose is career development: building and sustaining a pipeline of early-career investigators who can become independent leaders in patient-centered outcomes research (PCOR) and comparative effectiveness methods. The program is designed to support a mentored postdoctoral phase and then help the investigator transition, on a defined timeline, into an independent research role.
What larger goal is AHRQ trying to achieve with this program?
The larger policy goal is to strengthen national capacity to conduct rigorous real-world studies evaluating what works best for patients, with an emphasis on outcomes, quality, and value in health care.
How is the program structured?
The opportunity uses a two-stage K99/R00 structure. The first phase (K99) supports a mentored, postdoctoral research and training period. The second phase (R00) supports the transition to research independence once the investigator secures a stable, independent research position.
What does the K99 phase support?
The K99 phase supports a mentored postdoctoral period focused on developing advanced skills and expertise, particularly in comparative effectiveness and related PCOR methods. It is described as a time for intensive training, methodological growth, and expanding interdisciplinary perspectives so the awardee can design, execute, and interpret complex outcomes research relevant to patient care and health system decision-making.
What does the R00 phase support?
The R00 phase supports the investigator's transition to independence by providing resources once the investigator secures a stable, independent research position. The intent is to position the candidate to compete successfully for independent research support and establish a clear independent research direction.
Is this opportunity focused more on research projects or on investigator career development?
Based on the description provided, it is primarily a structured career-launch mechanism. The core emphasis is on moving a promising postdoctoral researcher from mentored development to independence, with PCOR and comparative effectiveness methods as the focus area.
How many awards were expected, and what was the estimated total funding?
The announcement projected about 10 awards, with an estimated total program funding level of $4,500,000.
What CFDA number is associated with this opportunity?
The associated CFDA number listed is 93.226 (Research on Healthcare Costs, Quality and Outcomes).
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was this funding opportunity posted, and what were the deadlines?
It was posted on June 1, 2012. The original and final application closing date was July 31, 2012.
Is this solicitation still active?
No. It was archived on August 31, 2012, indicating it was time-limited rather than an open-ended standing announcement.
Who can apply as the primary applicant organization?
Eligibility is structured primarily around U.S.-based public and nonprofit entities that can host and support the training-to-independence pathway. Eligible applicants include state governments; public and state-controlled institutions of higher education; federally recognized Native American tribal governments; and other tribal organizations.
Are faith-based or community-based organizations eligible to apply?
The announcement notes that other eligible applicants may include faith-based or community-based organizations, as long as they meet relevant requirements.
Can a for-profit organization apply as the lead applicant?
No. AHRQ's authorizing legislation does not allow for-profit organizations to serve as the lead applicant under this mechanism.
Can for-profit organizations participate in any way?
Yes. For-profit entities can be involved as consortium partners or subcontractors, but not as the primary applicant.
Can foreign institutions apply as the primary applicant?
No. Foreign institutions are not eligible to apply as the primary applicant. They may participate only through consortium or subcontract relationships.
Why does the opportunity limit foreign institutions to consortium or subcontract roles?
The description ties this restriction to the program's emphasis on improving health care in the United States.
Are there any organizations that are explicitly excluded from applying?
Yes. The announcement excludes certain organizations, including entities described in section 501(c)(4) of the Internal Revenue Code that engage in lobbying.
Does AHRQ allow the applicant organization to function mainly as a pass-through for funds?
No. The solicitation emphasizes that the award recipient organization must play a substantive, meaningful role in carrying out the work rather than functioning primarily as a pass-through.
What if much of the work will be done through consortium partners or contractors?
If a large portion of the work is being done through consortium or contracted arrangements, the applicant is expected to justify why it should be the grantee and clearly describe what it will do directly.
Does AHRQ define a specific budget percentage for what counts as "substantive involvement"?
No. Rather than using a strict budget percentage, AHRQ indicates it will evaluate substantive involvement based on the nature of the primary project activities and which organizations are performing them.
What kinds of research capabilities is the program trying to build?
The program aims to develop investigators who are strong methodologists in comparative effectiveness and PCOR methods and who can also design and lead complex outcomes research that informs patient care and health system decision-making in real-world settings.
Where does the announcement direct applicants to look for full details?
For full details, it directs applicants to the NIH Grants Guide posting (RFA-HS-12-007).
Who is listed for technical access issues?
The announcement provides NIH Office of Extramural Research (OER) webmaster contacts for technical access issues.
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