Opportunity Information: Apply for PA 12 178
Apply for PA 12 178
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Abuse, Sleep Disorders and Circadian Rhythms (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Apr 26, 2012 and posted on Apr 26, 2012.
- Applicants must submit their applications by May 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments County governments City or township governments Public and State controlled institutions of higher education Private institutions of higher education Special district governments Public housing authorities/Indian housing authorities Small businesses For profit organizations other than small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Alcohol Abuse, Sleep Disorders and Circadian Rhythms (R21) funding opportunity (PA 12-178) was a discretionary grant program issued by the National Institutes of Health (NIH), specifically through the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It supported exploratory and developmental research projects using the NIH R21 mechanism, which is generally meant for early-stage, high-impact ideas where investigators need seed funding to generate initial mechanistic data rather than run a large, fully mature program of research. The central purpose of this FOA was to encourage mechanistic studies that clarify how alcohol abuse interacts with circadian biology and sleep pathology, using either human research, animal models, or complementary approaches that connect findings across species.
Scientifically, the opportunity targeted the intersection of three tightly linked areas: alcohol misuse and alcohol use disorders, disruptions in circadian rhythms (the body’s internal timekeeping system that regulates daily physiological and behavioral cycles), and sleep disorders (including insomnia and other clinically meaningful disturbances of sleep architecture and timing). The FOA emphasized mechanism, meaning applications were expected to go beyond simple associations and instead test how and why these systems affect each other. In practical terms, responsive projects would likely examine biological pathways and neural circuits that tie alcohol exposure and withdrawal to altered sleep regulation, changes in circadian timing, and downstream effects on behavior, physiology, and risk for continued alcohol use. Because both sleep and circadian disruption can increase vulnerability to relapse and can also be worsened by alcohol intake, the FOA’s theme was well aligned with translational goals: identifying targets that could inform prevention, treatment, and recovery strategies.
From a program-structure standpoint, this was an R21 Exploratory/Developmental Research Grant, with an award ceiling listed at $275,000. The announcement specified that there was no cost-sharing or matching requirement. The CFDA number associated with the program was 93.273 (Alcohol Research Programs), reflecting its alignment with NIAAA’s mission to support research on the causes, consequences, prevention, and treatment of alcohol-related problems. The FOA was posted on April 26, 2012, and remained open through a final closing date of May 7, 2015, with an archive date of June 7, 2015. In other words, it is no longer an active funding opportunity, but it remains a useful reference point for understanding the kinds of projects NIAAA has sought in this scientific area and for shaping similar applications under newer announcements.
Eligibility under PA 12-178 was broad and included a wide range of U.S. and non-U.S. organizational types. Eligible applicants included state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education); small businesses and other for-profit entities; and Native American tribal governments and tribal organizations (including both federally recognized and other than federally recognized entities). The eligibility language also explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Importantly, the FOA allowed foreign institutions to apply, allowed non-domestic components of U.S. organizations, and permitted foreign components as defined in the NIH Grants Policy Statement, which signals openness to internationally relevant mechanistic research when justified by the science.
The announcement’s operational details also provided basic support contacts for technical access issues, directing applicants to the NIH Office of Extramural Research (OER) webmaster contacts for help with accessing or linking to the full FOA text. While the summary information here does not list specific required research topics, review criteria, or application instructions, the stated emphasis on mechanistic human and animal model studies makes clear the intent: to fund innovative, early-stage work capable of explaining biological and behavioral links between alcohol abuse, circadian dysregulation, and sleep disorders, with the expectation that successful R21 projects could later mature into larger, more definitive research programs.
Frequently Asked Questions (FAQs)
What is the "Alcohol Abuse, Sleep Disorders and Circadian Rhythms (R21)" opportunity (PA 12-178)?
PA 12-178 was a discretionary NIH funding opportunity that supported exploratory and developmental research on the mechanistic links between alcohol abuse, sleep disorders, and circadian rhythms. It used the NIH R21 mechanism, which is intended for early-stage, high-impact ideas that need seed funding to generate initial mechanistic data.
Which agency issued this funding opportunity?
The opportunity was issued by the National Institutes of Health (NIH), specifically through the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What type of grant mechanism did PA 12-178 use?
It used the NIH R21 Exploratory/Developmental Research Grant mechanism.
What kinds of projects was this FOA designed to support?
This FOA was designed to support mechanistic studies that clarify how alcohol abuse interacts with circadian biology and sleep pathology. Projects were expected to go beyond simple correlations and instead test how and why alcohol misuse, circadian disruption, and sleep disorders influence one another.
What scientific areas did this opportunity focus on?
The FOA targeted the intersection of (1) alcohol misuse and alcohol use disorders, (2) disruptions in circadian rhythms (the body’s internal timekeeping system regulating daily cycles), and (3) sleep disorders, including insomnia and other clinically meaningful disturbances in sleep architecture and timing.
Did the FOA emphasize mechanistic research or observational/associational research?
It emphasized mechanism. Applications were expected to investigate biological pathways, neural circuits, and other explanatory processes that connect alcohol exposure and withdrawal with altered sleep regulation and circadian timing, rather than focusing only on associations.
Were human studies allowed under PA 12-178?
Yes. The FOA allowed mechanistic studies using human research approaches.
Were animal model studies allowed under PA 12-178?
Yes. The FOA allowed animal model studies, as well as complementary approaches intended to connect findings across species.
Could projects combine human and animal model approaches?
Yes. The FOA explicitly supported complementary approaches that connect findings across species, which can include paired or integrated human and animal research strategies.
Why were sleep and circadian rhythms considered important in relation to alcohol abuse in this FOA?
The FOA highlighted that sleep and circadian disruption can increase vulnerability to relapse and can also be worsened by alcohol intake. Mechanistic insight in this area was viewed as relevant to translational goals such as identifying targets that could inform prevention, treatment, and recovery strategies.
What was the maximum award amount (ceiling) for this R21?
The award ceiling listed for this R21 opportunity was $275,000.
Was cost-sharing or matching required?
No. The announcement specified that there was no cost-sharing or matching requirement.
What CFDA number was associated with this opportunity?
The CFDA number associated with the program was 93.273, labeled as Alcohol Research Programs.
When was PA 12-178 posted?
The FOA was posted on April 26, 2012.
When did PA 12-178 close?
The final closing date was May 7, 2015.
Is this funding opportunity still active?
No. It is no longer an active funding opportunity. It remained open through May 7, 2015, and had an archive date of June 7, 2015.
What was the archive date for PA 12-178?
The archive date was June 7, 2015.
Who was eligible to apply?
Eligibility was broad and included many U.S. and non-U.S. organizational types, such as state/county/city governments, special district governments, public housing authorities/Indian housing authorities, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education), small businesses, and other for-profit entities.
Were Native American tribal governments and tribal organizations eligible?
Yes. Eligible applicants included Native American tribal governments and tribal organizations, including both federally recognized and other than federally recognized entities.
Did the eligibility language include specific institution types such as HBCUs or Hispanic-serving Institutions?
Yes. The eligibility language explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Were faith-based and community-based organizations eligible to apply?
Yes. The eligibility language explicitly included faith-based and community-based organizations.
Could federal agencies apply?
Yes. Eligible applicants included eligible federal agencies.
Were U.S. territories or possessions eligible?
Yes. The eligibility language included U.S. territories or possessions.
Could foreign institutions apply directly?
Yes. The FOA allowed foreign institutions to apply.
Were non-domestic components of U.S. organizations allowed?
Yes. The FOA allowed non-domestic components of U.S. organizations.
Were foreign components permitted under NIH policy?
Yes. The FOA permitted foreign components as defined in the NIH Grants Policy Statement.
What does the R21 mechanism generally aim to fund?
The R21 mechanism generally supports exploratory and developmental projects, often involving early-stage, potentially high-impact ideas where investigators need seed funding to generate initial mechanistic data rather than conduct a large, fully mature research program.
Does the provided summary list specific required research topics or review criteria?
No. The summary information provided here does not list specific required research topics, review criteria, or application instructions. It does, however, clearly state the emphasis on mechanistic human and animal model studies linking alcohol abuse, circadian dysregulation, and sleep disorders.
What kind of support contact was mentioned for access issues?
For technical access or linking issues, the announcement directed applicants to the NIH Office of Extramural Research (OER) webmaster contacts for help with accessing or linking to the full FOA text.
How can PA 12-178 still be useful if it is archived?
Although it is no longer active, it can still serve as a reference point for understanding the types of mechanistic projects NIAAA has supported in this scientific area and for shaping similar applications under newer announcements.
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