Opportunity Information: Apply for PA 12 025
Apply for PA 12 025
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol impairment of immune function, host defense and tissue homeostasis (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Nov 18, 2011 and posted on Nov 18, 2011.
- Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education County governments Small businesses Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments Independent school districts Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity announcement PA-12-025, titled "Alcohol impairment of immune function, host defense and tissue homeostasis (R01)," supports R01 grant applications focused on how alcohol use disrupts the immune system and how those disruptions translate into real-world health harms. The central scientific premise behind the announcement is that alcohol-related morbidity and mortality are heavily driven by two outcomes: higher susceptibility to infections and increased organ damage. Both are strongly linked to significant impairment of innate and adaptive immunity, yet the specific biological mechanisms and the step-by-step connections between immune dysfunction and clinical disease are still not well defined in many areas.
This opportunity aims to attract basic and translational research that advances three major goals. First, it seeks studies that identify and explain how alcohol alters immune function, which can include effects on immune cell development, trafficking, signaling pathways, cytokine responses, barrier defenses, inflammatory resolution, and other core processes that determine whether the body can recognize and clear pathogens effectively. Second, it encourages projects that establish functional links between alcohol-driven immune alterations and downstream medical consequences, especially alcohol-related infections and alcohol-associated organ injury. In practice, that emphasis favors proposals that move beyond describing immune changes and instead demonstrate how those changes contribute to susceptibility, severity, or progression of infection and tissue damage in relevant experimental or clinical contexts. Third, it supports research that develops strategies to mitigate or reverse immune impairment caused by alcohol, with the explicit intent of reducing alcohol-induced pathology. These mitigation approaches could include mechanistic targets for therapeutic intervention, immune-modulating strategies, or other biologically grounded methods that could eventually inform prevention or treatment.
Administratively, the program is a discretionary grant opportunity using the NIH R01 research project grant mechanism and falls under the health activity category, with CFDA number 93.273 (Alcohol Research Programs). The announcement states that there is no cost sharing or matching requirement. The opportunity was posted and created on November 18, 2011, with an original and current closing date of January 7, 2015, and an archive date of February 7, 2015, indicating it is no longer open for new applications under that specific announcement.
Eligibility is broad and includes many types of domestic applicants such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations (including those other than small businesses), and a wide range of governmental entities (state, county, city/township, special district, and public housing authorities/Indian housing authorities). The eligibility list also explicitly includes Native American tribal governments (federally recognized and other than federally recognized), independent school districts, and regional organizations. In addition, the FOA allows non-U.S. entities (foreign institutions) to apply, permits non-domestic components of U.S. organizations, and allows foreign components as defined by the NIH Grants Policy Statement. It also notes eligibility for institutions and organizations that serve specific communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, as well as faith-based or community-based organizations and U.S. territories or possessions.
For reference and full announcement details, NIH provided an additional information link at http://grants.nih.gov/grants/guide/pa-files/PA-12-025.html, and technical access questions were directed to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is PA-12-025?
PA-12-025 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "Alcohol impairment of immune function, host defense and tissue homeostasis (R01)." It invited R01 research project grant applications focused on how alcohol use disrupts the immune system and how that disruption leads to real-world health harms.
What type of grant mechanism does this opportunity use?
This FOA uses the NIH R01 research project grant mechanism.
What is the main scientific focus of the announcement?
The FOA focuses on alcohol-related impairment of immune function, including how alcohol affects innate and adaptive immunity, host defense against pathogens, and tissue homeostasis. A central premise is that alcohol-related illness and death are strongly driven by increased susceptibility to infections and increased organ damage, both of which are linked to immune impairment.
What health outcomes does the FOA emphasize?
The FOA highlights two major outcomes associated with alcohol-related morbidity and mortality: (1) higher susceptibility to infections and (2) increased organ damage. It emphasizes that both outcomes are strongly tied to impairment of immune function.
What are the major research goals supported by this opportunity?
The FOA aims to attract basic and translational research advancing three main goals: (1) identifying and explaining how alcohol alters immune function, (2) establishing functional links between alcohol-driven immune alterations and medical consequences such as infections and organ injury, and (3) developing strategies to mitigate or reverse alcohol-related immune impairment to reduce alcohol-induced pathology.
What kinds of immune processes are mentioned as relevant areas of study?
The FOA notes that studies may address how alcohol affects immune cell development, trafficking, signaling pathways, cytokine responses, barrier defenses, inflammatory resolution, and other core processes that influence pathogen recognition and clearance.
Does the FOA encourage projects beyond descriptive immune findings?
Yes. The FOA explicitly emphasizes proposals that go beyond describing immune changes and instead demonstrate how those changes contribute to susceptibility, severity, or progression of infection and tissue damage in relevant experimental or clinical contexts.
Does this opportunity support translational research?
Yes. The FOA states it seeks both basic and translational research, including work that connects alcohol-driven immune alterations to downstream clinical or medical consequences.
Does the FOA support development of interventions or mitigation strategies?
Yes. A major goal is to support research that develops strategies to mitigate or reverse immune impairment caused by alcohol, with the intent of reducing alcohol-induced pathology. The FOA mentions approaches such as mechanistic targets for therapeutic intervention and immune-modulating strategies.
What is the CFDA number and program category listed for this opportunity?
The FOA is listed under CFDA number 93.273, Alcohol Research Programs, and falls under the health activity category.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Is PA-12-025 currently open for applications?
No. The FOA is no longer open. It was posted and created on November 18, 2011, with an original and current closing date of January 7, 2015, and an archive date of February 7, 2015.
When was the FOA posted and when did it close?
It was posted (and created) on November 18, 2011. The original and current closing date listed is January 7, 2015. The archive date is February 7, 2015.
Who is eligible to apply (in general terms)?
Eligibility is broad. The FOA allows applications from many types of domestic organizations (including higher education, nonprofits, businesses, for-profits, and government entities) and also permits applications from non-U.S. entities (foreign institutions) and foreign components as defined by the NIH Grants Policy Statement.
What types of U.S. higher education institutions are eligible?
The FOA includes public and private institutions of higher education among eligible applicants.
Are nonprofits eligible to apply?
Yes. The eligibility list includes nonprofits, including 501(c)(3) organizations and certain non-501(c)(3) nonprofits.
Are small businesses and for-profit organizations eligible?
Yes. The FOA includes small businesses, for-profit organizations (including those other than small businesses), and other business categories listed as eligible applicants.
Are governmental entities eligible to apply?
Yes. The eligibility list includes state, county, city/township, special district governments, and public housing authorities/Indian housing authorities, among others.
Are Native American tribal governments eligible?
Yes. The FOA explicitly includes Native American tribal governments (federally recognized) and Native American tribal governments (other than federally recognized).
Are school districts or regional organizations eligible?
Yes. The eligibility list explicitly includes independent school districts and regional organizations.
Can foreign institutions apply?
Yes. The FOA allows non-U.S. entities (foreign institutions) to apply.
Can U.S. organizations include non-U.S. components?
Yes. The FOA permits non-domestic components of U.S. organizations and allows foreign components as defined by the NIH Grants Policy Statement.
Are institutions serving specific communities explicitly mentioned as eligible?
Yes. The FOA notes eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and also includes faith-based or community-based organizations and U.S. territories or possessions.
Where can I find the full FOA text and official details?
The NIH provided an additional information link to the full announcement details at: http://grants.nih.gov/grants/guide/pa-files/PA-12-025.html
Who is listed for technical access questions about the announcement?
Technical access questions were directed to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overarching rationale NIH gives for the research area?
The FOA states that alcohol-related morbidity and mortality are heavily driven by increased infections and organ damage, and that both are strongly linked to impaired innate and adaptive immunity. It also notes that the specific mechanisms and step-by-step connections between immune dysfunction and clinical disease are still not well defined in many areas, motivating further research.
Does the FOA mention tissue homeostasis?
Yes. The FOA title and scope include tissue homeostasis, reflecting interest in how alcohol-related immune disruption can contribute to broader tissue and organ health outcomes.
What kinds of downstream consequences are specifically highlighted?
The FOA specifically highlights alcohol-related infections and alcohol-associated organ injury as downstream medical consequences that proposals should help connect to alcohol-driven immune alterations.
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