Opportunity Information: Apply for PA 12 026
Apply for PA 12 026
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol impairment of immune function, host defense and tissue homeostasis (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Nov 18, 2011 and posted on Nov 18, 2011.
- Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Native American tribal governments (Federally recognized) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Special district governments City or township governments County governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This NIH grant opportunity (Funding Opportunity Number PA-12-026) is an R21 exploratory/developmental research announcement focused on how alcohol use disrupts immune function and, in turn, increases the risk of infections and organ damage. The program is rooted in the idea that two of the biggest drivers of alcohol-related illness and death are (1) heightened susceptibility to infectious disease and (2) damage to major organs, and that both outcomes are strongly tied to alcohol-induced breakdowns in the body’s innate and adaptive immune defenses. NIH is signaling that, despite clear clinical connections, the underlying biological mechanisms are still not well mapped out, and the field needs more targeted basic and translational studies that can explain what alcohol is doing to immune cells, immune signaling, and tissue maintenance, and why those changes translate into real-world medical harm.
The scientific goals are laid out in three broad priorities. First, the FOA seeks projects that identify the specific ways alcohol alters immune function, which can include changes in immune cell development, trafficking, activation thresholds, cytokine production, antigen presentation, barrier immunity, inflammation resolution, and other core immune processes. Second, it encourages applicants to connect these immune changes to tangible health outcomes, particularly alcohol-related infections and alcohol-associated organ injury. In other words, it is not only asking whether alcohol changes immunity, but also pushing investigators to demonstrate functional links that explain increased disease severity, poor pathogen clearance, dysregulated inflammation, delayed healing, or progressive tissue injury in relevant organs. Third, the FOA explicitly invites work aimed at mitigation: strategies to prevent, reverse, or compensate for immune impairment caused by alcohol, with the longer-term aim of reducing alcohol-induced pathology. That mitigation could be conceptual (identifying actionable pathways) or more directly intervention-oriented (testing candidate therapeutics, immune modulators, nutritional or metabolic approaches, or other countermeasures), as long as it is grounded in solid mechanistic rationale.
From an administrative standpoint, this is a discretionary NIH grant using the R21 mechanism, which is typically used for early-stage, high-impact ideas that may be more exploratory than a full-scale R01. The award ceiling listed is 200,000, and the announcement indicates there is no cost sharing or matching requirement. The activity category is health, and it falls under CFDA 93.273 (Alcohol Research Programs). The opportunity was posted and created on Nov 18, 2011, with an original and current closing date of Jan 7, 2015, and an archive date of Feb 7, 2015, meaning it is no longer open but remains useful as a reference point for the kinds of projects NIH has actively sought in this space.
Eligibility is broad and includes a wide range of domestic and non-domestic institutions. Eligible applicants include for-profit organizations (other than small businesses) and small businesses, nonprofit organizations (with or without 501(c)(3) status), private and public institutions of higher education, and multiple levels of government (state, county, city/township, special districts, independent school districts), as well as public housing authorities/Indian housing authorities. The FOA also highlights eligibility for a range of mission-serving and community-based entities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and regional organizations. Foreign institutions are allowed to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are permitted as defined in the NIH Grants Policy Statement, which underscores NIH’s openness to global expertise and collaborations in alcohol-immunology research.
The sponsoring agency is the National Institutes of Health, and the full announcement was hosted on the NIH grants site. For technical issues accessing the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH Grant PA-12-026 (R21) - Alcohol Use, Immune Disruption, Infections, and Organ Damage
What is this funding opportunity?
This is an NIH grant opportunity (Funding Opportunity Number PA-12-026) using the R21 exploratory/developmental research mechanism. It focuses on research examining how alcohol use disrupts immune function and how those immune disruptions contribute to higher risk of infections and organ damage.
What problem is NIH trying to address through this FOA?
The FOA is built around the view that two major drivers of alcohol-related illness and death are increased susceptibility to infectious disease and damage to major organs. NIH is emphasizing that both outcomes are closely connected to alcohol-induced breakdowns in innate and adaptive immune defenses, but that the biological mechanisms linking alcohol exposure to immune dysfunction and medical harm are still not fully mapped out.
What type of research does the R21 mechanism support in this announcement?
The R21 mechanism is typically used for early-stage, high-impact, and more exploratory or developmental ideas than a full-scale R01. In this FOA, that exploratory focus is directed at generating targeted basic and translational studies that can clarify mechanisms by which alcohol alters immune cells, immune signaling, and tissue maintenance.
What are the main scientific priorities described in the FOA?
The FOA lays out three broad priorities:
- Identifying specific ways alcohol alters immune function (across core immune processes).
- Connecting immune changes to real health outcomes, especially alcohol-related infections and alcohol-associated organ injury.
- Developing or informing mitigation strategies to prevent, reverse, or compensate for alcohol-related immune impairment.
What kinds of immune effects or mechanisms are in scope?
The FOA describes a range of immune processes that may be examined, including changes in immune cell development, trafficking, activation thresholds, cytokine production, antigen presentation, barrier immunity, inflammation resolution, and other fundamental immune functions.
Does the FOA emphasize linking immune changes to clinical or functional outcomes?
Yes. The FOA is not limited to demonstrating that alcohol changes immunity. It also pushes applicants to establish functional links showing how immune alterations translate into tangible harms, such as increased disease severity, poor pathogen clearance, dysregulated inflammation, delayed healing, or progressive tissue injury in relevant organs.
Are projects aimed at prevention or reversal of immune impairment encouraged?
Yes. The FOA explicitly invites work aimed at mitigation, including strategies to prevent, reverse, or compensate for immune impairment caused by alcohol, with the longer-term goal of reducing alcohol-induced pathology.
What kinds of mitigation approaches are mentioned as examples?
The FOA notes that mitigation can be conceptual (for example, identifying actionable pathways) or intervention-oriented (for example, testing candidate therapeutics, immune modulators, nutritional or metabolic approaches, or other countermeasures), as long as the approach is grounded in a solid mechanistic rationale.
What is the maximum award amount mentioned?
The award ceiling listed in the provided description is 200,000.
Is cost sharing or matching required?
No. The announcement indicates there is no cost sharing or matching requirement.
What is the activity category and CFDA number for this opportunity?
The activity category is health, and it falls under CFDA 93.273 (Alcohol Research Programs).
When was this funding opportunity posted, and is it still open?
The opportunity was posted and created on Nov 18, 2011. The original and current closing date listed is Jan 7, 2015. The archive date is Feb 7, 2015. Based on those dates, the opportunity is no longer open and is maintained as an archived reference.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site.
Who is eligible to apply?
Eligibility is described as broad and includes domestic and non-domestic institutions. The eligible applicant types listed include:
- For-profit organizations (other than small businesses)
- Small businesses
- Nonprofit organizations (with or without 501(c)(3) status)
- Private and public institutions of higher education
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public housing authorities / Indian housing authorities
Does NIH encourage applications from specific institution types or community-based entities?
Yes. The FOA highlights eligibility for several mission-serving and community-based entities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and regional organizations.
Are foreign institutions or international components allowed?
Yes. Foreign institutions are allowed to apply. Non-U.S. components of U.S. organizations are eligible. Foreign components are also permitted as defined in the NIH Grants Policy Statement.
What is the overarching research theme of the program?
The program centers on understanding how alcohol-related immune dysfunction contributes to infections and organ damage, and on clarifying the biological mechanisms that connect alcohol exposure to breakdowns in innate and adaptive immune defenses and to downstream tissue injury and disease risk.
Who should be contacted for technical problems accessing the announcement?
For technical issues accessing the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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