Opportunity Information: Apply for PA 12 027
Apply for PA 12 027
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Effects of adolescent binge drinking on brain development (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Nov 18, 2011 and posted on Nov 18, 2011.
- Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Independent school districts County governments State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments Public and State controlled institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity "Effects of adolescent binge drinking on brain development (R01)" (Funding Opportunity Number PA-12-027) was issued by the National Institutes of Health through the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It supports discretionary, health-related research under the NIH Research Project Grant (R01) mechanism and is tied to CFDA number 93.273 (Alcohol Research Programs). The core purpose of the announcement is to stimulate mechanistic research that explains how binge-pattern alcohol exposure during adolescence affects key neurodevelopmental processes, with a specific emphasis on synaptic maturation and myelin formation while the brain is still developing. In practical terms, NIAAA is looking for projects that move beyond describing behavioral or clinical associations and instead dig into biological and cellular pathways that could account for lasting changes in brain structure and function following adolescent binge drinking.
Scientifically, the FOA is centered on adolescence as a sensitive developmental window, when neuronal connections are being refined and strengthened and when white matter pathways are being insulated and optimized through myelination. By focusing on synaptic maturation, the announcement signals interest in how alcohol may alter the formation, pruning, and stabilization of synapses, as well as the molecular signaling that guides these processes. By highlighting myelin formation, it also points to potential impacts on oligodendrocytes and other components of white matter development, which are crucial for efficient neural communication and can influence cognition, learning, emotional regulation, and impulse control. The emphasis on "mechanistic studies" implies that proposed research should be designed to reveal causative pathways and underlying biology, for example by identifying cellular targets of alcohol exposure, characterizing changes in neural circuitry development, or clarifying how alcohol disrupts normal developmental trajectories in the adolescent brain.
From an administrative standpoint, this is a grant (not a contract) with no cost sharing or matching requirement. The opportunity was posted and created on November 18, 2011. The original and final closing date listed is January 7, 2015, and the archive date is February 7, 2015, meaning the program is no longer accepting applications under this specific announcement as written, but it remains useful as a reference point for the kind of science NIAAA sought to encourage and for identifying similar active NIH opportunities.
Eligibility for the FOA is broad and includes a wide range of domestic organizational types, such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other than small businesses), and multiple levels of government (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). It also explicitly includes tribal entities and tribal organizations. The eligibility language further clarifies that many mission-focused institution types are welcome to apply, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Notably, non-U.S. entities (foreign institutions) are eligible, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by the NIH Grants Policy Statement, which broadens the applicant pool to include international expertise where it strengthens the science.
For applicants trying to locate the full text of the announcement, the FOA provided an official NIH link (http://grants.nih.gov/grants/guide/pa-files/PA-12-027.html). For technical issues accessing the announcement or resolving linking problems, the listed point of contact was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Effects of adolescent binge drinking on brain development (R01)" and the Funding Opportunity Number (FOA) is PA-12-027.
Which agency and institute issued this funding opportunity?
This FOA was issued by the National Institutes of Health (NIH) through the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What type of funding mechanism does this opportunity use?
It uses the NIH Research Project Grant (R01) mechanism and supports discretionary, health-related research.
Is this opportunity a grant or a contract?
This opportunity is a grant (not a contract).
What is the CFDA number associated with this program?
The CFDA number is 93.273, listed as Alcohol Research Programs.
What is the main scientific purpose of this FOA?
The purpose is to stimulate mechanistic research explaining how binge-pattern alcohol exposure during adolescence affects key neurodevelopmental processes, with specific emphasis on synaptic maturation and myelin formation while the brain is still developing.
What does NIAAA mean by "mechanistic" research in this announcement?
Based on the FOA description, "mechanistic" implies studies designed to reveal causative pathways and underlying biology (not only behavioral or clinical associations). Examples described include identifying cellular targets of alcohol exposure, characterizing changes in neural circuitry development, or clarifying how alcohol disrupts normal developmental trajectories in the adolescent brain.
Why does the FOA focus on adolescence?
The FOA frames adolescence as a sensitive developmental window when neuronal connections are being refined and strengthened and when white matter pathways are being optimized through myelination.
What specific brain development topics are emphasized?
The announcement specifically emphasizes synaptic maturation and myelin formation.
What aspects of synaptic maturation does the FOA highlight?
It highlights interest in how alcohol may alter the formation, pruning, and stabilization of synapses, along with the molecular signaling that guides these processes.
What aspects of myelin formation does the FOA highlight?
It points to potential impacts on oligodendrocytes and other components of white matter development, which the FOA notes are crucial for efficient neural communication and can influence cognition, learning, emotional regulation, and impulse control.
Is the FOA aimed at descriptive studies or biological pathway studies?
The FOA indicates NIAAA is looking for projects that move beyond describing behavioral or clinical associations and instead investigate biological and cellular pathways that could account for lasting changes in brain structure and function following adolescent binge drinking.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was this funding opportunity posted/created?
The opportunity was posted and created on November 18, 2011.
What was the closing date for applications under this announcement?
The original and final closing date listed is January 7, 2015.
Is this funding opportunity still accepting applications?
No. The archive date is February 7, 2015, which indicates the program is no longer accepting applications under this specific announcement as written.
If it is archived, is the FOA still useful?
Yes. The description notes it can still be useful as a reference point for the kind of science NIAAA sought to encourage and for identifying similar active NIH opportunities.
Who is eligible to apply?
Eligibility is broad. It includes many domestic organization types such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other than small businesses), and multiple levels of government (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). Tribal entities and tribal organizations are also included.
Are mission-focused and special designation institutions included as eligible applicants?
Yes. The eligibility language explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Are foreign (non-U.S.) institutions eligible?
Yes. Non-U.S. entities (foreign institutions) are eligible, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by the NIH Grants Policy Statement.
Where can applicants find the official full text of the FOA?
The FOA provided this official NIH link: http://grants.nih.gov/grants/guide/pa-files/PA-12-027.html
Who should be contacted for technical issues accessing the announcement or link problems?
The listed point of contact for technical issues was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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