Opportunity Information: Apply for PA 14 123
Apply for PA 14 123
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Induced Effects on Tissue Injury and Repair (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Feb 28, 2014 and posted on Feb 28, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public housing authorities/Indian housing authorities For profit organizations other than small businesses State governments Special district governments Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Alcohol Induced Effects on Tissue Injury and Repair (R01) funding opportunity (PA 14-123) is a National Institutes of Health grant announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) that supports Research Project Grant (R01) applications focused on how alcohol use influences tissue damage and the body s ability to recover. The central goal is to move beyond describing alcohol related harm and instead dig into the underlying molecular and cellular mechanisms that drive injury, delayed healing, and impaired repair processes in humans. The program emphasizes that these mechanisms are still not fully understood, especially in the context of how alcohol exposure changes biological responses during and after injury or trauma.
A major theme of the opportunity is that excessive alcohol consumption can negatively affect many organ systems, and applicants are encouraged to address both organ specific and cross cutting biology. The FOA highlights a wide range of targets where alcohol related injury and altered recovery may be important, including the liver, brain, heart, pancreas, lung, kidney, endocrine and immune systems, and musculoskeletal tissues such as bone and skeletal muscle. It also points to growing evidence that long term alcohol use reduces the host s capacity for recovery and repair following trauma, suggesting an interest in studies that examine why healing is worse, slower, or incomplete in people with chronic alcohol exposure, and which pathways are responsible.
NIAAA signals strong interest in integrative research that can connect mechanisms across levels of biology rather than staying confined to a single narrow pathway. That includes work that clarifies whether alcohol disrupts shared repair programs that operate in many tissues (such as inflammation resolution, extracellular matrix remodeling, angiogenesis, oxidative stress responses, mitochondrial function, immune cell programming, or fibrosis pathways) versus mechanisms that are unique to certain organs. In addition to chronic heavy drinking, the FOA explicitly encourages research on the molecular and cellular actions of moderate alcohol consumption, which broadens the scope to include studies that may differentiate dose dependent effects, patterns of exposure, and the biological contexts where alcohol related changes become clinically meaningful.
Another highlighted area is alcohol effects on stem cells, embryonic development, and regeneration. This reflects interest in how alcohol may alter stem or progenitor cell function, differentiation, and tissue renewal capacity, and how these changes could influence development and long term repair potential. Overall, the practical motivation behind the FOA is translational: by understanding the basic mechanisms that link alcohol exposure to organ damage and impaired healing, the research could open up new avenues for prognosis (risk prediction and outcome stratification), diagnosis (biomarkers and mechanistic signatures), intervention (targeting repair pathways), and treatment strategies for alcohol induced organ injury.
Administratively, this is a discretionary NIH grant opportunity using the R01 mechanism in the health funding category under CFDA 93.273 (Alcohol Research Programs). Cost sharing or matching is not required. The opportunity was posted February 28, 2014, with an original and current closing date of May 7, 2017, and an archive date of June 7, 2017. Eligibility is broad and includes many U.S. applicant types such as universities (public and private), nonprofits (including 501(c)(3) and non 501(c)(3)), small businesses and other for profit organizations (other than small businesses are also listed as eligible), state, local, county, city, township, and special district governments, independent school districts, public housing authorities and Indian housing authorities, and tribal governments and organizations. The announcement also notes expanded eligibility categories such as HBCUs, Hispanic serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith based or community based organizations, and eligible federal agencies. Importantly, non U.S. entities are allowed to apply as foreign organizations or foreign institutions, non U.S. components of U.S. organizations are eligible, and foreign components are permitted as defined by NIH policy.
For reference, the full announcement is linked at http://grants.nih.gov/grants/guide/pa-files/PA-14-123.html and technical access issues were directed to the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Alcohol Induced Effects on Tissue Injury and Repair (R01)" and is associated with FOA number PA-14-123.
Which agency and institute are offering this funding opportunity?
This is a National Institutes of Health (NIH) grant announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What grant mechanism does this opportunity use?
The opportunity uses the Research Project Grant (R01) mechanism.
What is the main purpose or goal of this FOA?
The central goal is to support R01 research that goes beyond describing alcohol-related harm and instead investigates the molecular and cellular mechanisms by which alcohol use influences tissue injury, delayed healing, impaired repair, and recovery in humans.
What kinds of scientific questions is NIAAA trying to answer through this program?
NIAAA is interested in understanding why and how alcohol exposure changes biological responses during and after injury or trauma, including why healing may be worse, slower, or incomplete, especially with chronic alcohol exposure, and which pathways drive these outcomes.
Is the focus only on chronic heavy drinking, or can moderate alcohol exposure be studied too?
The FOA explicitly encourages research on the molecular and cellular actions of moderate alcohol consumption as well as chronic heavy drinking. This supports studies that compare dose-dependent effects, patterns of exposure, and contexts where alcohol-related changes become clinically meaningful.
Which organs or tissues are specifically mentioned as areas of interest?
The FOA highlights potential alcohol-related injury and altered recovery across many targets, including the liver, brain, heart, pancreas, lung, kidney, as well as the endocrine and immune systems, and musculoskeletal tissues such as bone and skeletal muscle.
Does the FOA encourage studies that look across multiple organ systems?
Yes. A major theme is that excessive alcohol consumption can negatively affect many organ systems, and applicants are encouraged to address both organ-specific biology and cross-cutting mechanisms that may operate across tissues.
What does the FOA mean by "integrative research"?
The FOA signals strong interest in integrative work that connects mechanisms across levels of biology rather than focusing narrowly on a single pathway. This includes clarifying whether alcohol disrupts shared repair programs across tissues versus mechanisms that are unique to specific organs.
What shared repair processes or pathways are named as examples in the FOA?
Examples of cross-cutting processes include inflammation resolution, extracellular matrix remodeling, angiogenesis, oxidative stress responses, mitochondrial function, immune cell programming, and fibrosis pathways.
Is trauma and impaired healing after injury part of the program's interest?
Yes. The FOA points to growing evidence that long-term alcohol use can reduce the host capacity for recovery and repair following trauma, and highlights interest in research examining why outcomes are worse and which pathways are responsible.
Are stem cells and regeneration within scope for this opportunity?
Yes. The FOA highlights alcohol effects on stem cells, embryonic development, and regeneration, including how alcohol may alter stem/progenitor cell function, differentiation, tissue renewal capacity, and long-term repair potential.
Is this FOA intended to support translational impact?
Yes. The practical motivation is translational: by understanding mechanisms linking alcohol exposure to organ damage and impaired healing, the research could enable new approaches for prognosis (risk prediction and stratification), diagnosis (biomarkers and mechanistic signatures), intervention (targeting repair pathways), and treatment strategies for alcohol-induced organ injury.
What funding category and CFDA number are associated with this opportunity?
This is in the health funding category and is associated with CFDA 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching is not required.
When was this opportunity posted?
The opportunity was posted on February 28, 2014.
What were the closing and archive dates listed for this FOA?
The original and current closing date listed is May 7, 2017, and the archive date is June 7, 2017.
Who is eligible to apply?
Eligibility is broad and includes many U.S. applicant types such as public and private universities, nonprofits (including 501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations (including those other than small businesses), and multiple levels of government including state, local/county/city/township, and special district governments. It also includes independent school districts, public housing authorities and Indian housing authorities, as well as tribal governments and organizations.
Are specific institution types (like minority-serving institutions) mentioned as eligible?
Yes. The announcement notes expanded eligibility categories including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, AANAPISIs, and faith-based or community-based organizations, among others listed as eligible.
Can non-U.S. organizations apply?
Yes. The announcement states that non-U.S. entities are allowed to apply as foreign organizations or foreign institutions. It also notes that non-U.S. components of U.S. organizations are eligible and that foreign components are permitted as defined by NIH policy.
Where can applicants find the full FOA announcement?
The full announcement is available at: http://grants.nih.gov/grants/guide/pa-files/PA-14-123.html
Who is listed as the contact for technical access issues?
Technical access issues were directed to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Does the FOA indicate that key mechanisms are not fully understood?
Yes. The program emphasizes that mechanisms driving alcohol-related injury, delayed healing, and impaired repair are still not fully understood, particularly regarding how alcohol exposure changes biological responses during and after injury or trauma.
Is this described as a discretionary NIH grant opportunity?
Yes. The opportunity is described as a discretionary NIH grant opportunity using the R01 mechanism.
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