Opportunity Information: Apply for PA 14 124
Apply for PA 14 124
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Induced Effects on Tissue Injury and Repair (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Feb 28, 2014 and posted on Feb 28, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments City or township governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Alcohol Induced Effects on Tissue Injury and Repair (R21) is a National Institutes of Health funding opportunity (PA-14-124) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) that supports early stage, exploratory research on how alcohol use influences the biological processes that drive tissue injury and the body s ability to repair itself. The focus is on molecular and cellular mechanisms in humans, with an emphasis on generating new mechanistic insights rather than delivering a fully mature, large scale program of work. The award mechanism is the NIH Exploratory/Developmental Research Grant (R21), which is commonly used for high impact ideas, novel hypotheses, or emerging approaches that need initial proof of concept data.
The scientific problem behind the announcement is that excessive alcohol consumption can damage many organ systems and appears to weaken recovery after injury or trauma, yet the precise mechanisms that link alcohol exposure to impaired healing and repair are still not well defined. The FOA highlights that alcohol related injury is not limited to one organ. It can involve the liver, brain, heart, pancreas, lung, kidney, endocrine and immune systems, as well as bone and skeletal muscle. In parallel, there is growing evidence that long term alcohol use reduces the host capacity for recovery, meaning alcohol may interfere with inflammation control, immune competence, tissue remodeling, vascular responses, and other coordinated steps required for repair. NIAAA signals particular interest in integrative research that connects these pieces and clarifies which pathways are shared across organs versus which are organ specific.
In terms of the kinds of studies the FOA aims to stimulate, it encourages projects that dig into complex injury and repair biology under alcohol exposure, including cross talk among cell types, signaling networks, and systemic factors. It also explicitly welcomes work on alcohol effects on stem cells, embryonic development, and regeneration, reflecting interest in how alcohol might alter progenitor cell function, differentiation, and long term tissue maintenance. Another notable element is that the FOA does not restrict attention only to heavy drinking. It also encourages studies on the molecular and cellular actions of moderate alcohol consumption, which opens the door to carefully designed mechanistic comparisons across exposure levels, patterns of drinking, and timing relative to injury.
The practical rationale for funding this area is translational: better mechanistic understanding can create new avenues for prognosis, diagnosis, intervention, and treatment of alcohol induced organ damage. In other words, the expectation is that clarifying pathways and cellular behaviors affected by alcohol could yield biomarkers of risk or poor healing, reveal therapeutic targets to improve recovery after trauma or surgery, or inform strategies to prevent organ damage progression in people with alcohol use.
Administratively, this is a discretionary grant opportunity in the health activity category (CFDA 93.273, Alcohol Research Programs). Cost sharing or matching is not required. The opportunity was posted February 28, 2014, with an original and final closing date of May 7, 2017, and it was archived June 7, 2017. The listed award ceiling is 200,000 (as provided in the source data). Eligibility is broad and includes public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for profit organizations (including small businesses and other for profits), state and local governments, special district governments, independent school districts, tribal governments and tribal organizations, public housing authorities, and a wide range of mission specific institution types such as HBCUs, Hispanic serving institutions, tribal colleges and universities, and Alaska Native and Native Hawaiian serving institutions. Foreign organizations and foreign institutions are eligible to apply, and foreign components of U.S. organizations are allowed consistent with NIH policy. The full announcement was provided via the NIH Grants Guide, and NIH s Office of Extramural Research webmaster contact was listed for access or linking issues.
Frequently Asked Questions (FAQs)
What is the grant opportunity called?
The opportunity is titled Alcohol Induced Effects on Tissue Injury and Repair (R21). It is associated with NIH Funding Opportunity Announcement PA-14-124.
Which agency and institute are offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main purpose of this funding opportunity?
The purpose is to support early-stage, exploratory research on how alcohol use influences the biological processes that drive tissue injury and the body’s ability to repair itself, with an emphasis on producing new mechanistic insights.
What type of grant mechanism is used?
The award mechanism is the NIH Exploratory/Developmental Research Grant (R21), which is commonly used for high-impact ideas, novel hypotheses, and emerging approaches that need initial proof-of-concept data.
What kind of research does the FOA emphasize?
The FOA emphasizes research on molecular and cellular mechanisms in humans related to alcohol’s impact on injury and repair, prioritizing mechanism-focused studies rather than fully mature, large-scale programs of work.
Why is this research area important according to the announcement?
The FOA highlights that excessive alcohol consumption can damage many organ systems and may weaken recovery after injury or trauma, but the precise mechanisms connecting alcohol exposure to impaired healing and repair are still not well defined.
Which organ systems and tissues are included in the scope?
The FOA notes alcohol-related injury can involve multiple systems and tissues, including the liver, brain, heart, pancreas, lung, kidney, endocrine and immune systems, as well as bone and skeletal muscle.
Does the FOA encourage research across multiple organs or systems?
Yes. NIAAA signals particular interest in integrative research that clarifies how alcohol affects coordinated repair processes and helps distinguish shared pathways across organs from organ-specific mechanisms.
What biological processes related to healing and repair are highlighted?
The FOA suggests alcohol may interfere with multiple coordinated steps required for repair, including inflammation control, immune competence, tissue remodeling, vascular responses, and other repair-related processes.
What kinds of study topics or approaches are encouraged?
The FOA encourages projects that explore complex injury and repair biology under alcohol exposure, including cross-talk among cell types, signaling networks, and systemic factors.
Are stem cells, regeneration, or development topics within scope?
Yes. The FOA explicitly welcomes work on alcohol effects on stem cells, embryonic development, and regeneration, including how alcohol may alter progenitor cell function, differentiation, and long-term tissue maintenance.
Is the FOA limited to heavy drinking or excessive alcohol use?
No. The FOA does not restrict attention only to heavy drinking. It also encourages studies on the molecular and cellular actions of moderate alcohol consumption, including comparisons across exposure levels, drinking patterns, and timing relative to injury.
What is the translational rationale for funding this work?
The FOA frames the rationale as translational: improved mechanistic understanding may open new avenues for prognosis, diagnosis, intervention, and treatment of alcohol-induced organ damage, including potential biomarkers of risk or poor healing and possible therapeutic targets to improve recovery.
What is the activity category and CFDA number?
The opportunity is in the health activity category and is associated with CFDA 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching is not required.
What is the maximum award amount (award ceiling) listed?
The listed award ceiling is 200,000 (as provided in the source data).
When was the opportunity posted and when did it close?
It was posted on February 28, 2014. The original and final closing date listed is May 7, 2017.
Is this funding opportunity still active?
No. The listing indicates the opportunity was archived on June 7, 2017.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses), state and local governments, special district governments, independent school districts, tribal governments and tribal organizations, public housing authorities, and mission-specific institution types such as HBCUs, Hispanic-serving institutions, tribal colleges and universities, and Alaska Native and Native Hawaiian-serving institutions.
Are foreign organizations or institutions eligible?
Yes. Foreign organizations and foreign institutions are eligible to apply, and foreign components of U.S. organizations are allowed consistent with NIH policy.
Where was the full announcement published?
The full announcement was provided via the NIH Grants Guide.
Who was listed as a contact for access or linking issues?
The listing notes that the NIH Office of Extramural Research webmaster contact was provided for access or linking issues.
What is the general problem statement behind the FOA?
The FOA is motivated by evidence that alcohol can cause multi-organ injury and may reduce the body’s capacity to recover after injury or trauma, while the specific mechanistic links between alcohol exposure and impaired healing remain insufficiently defined.
Does the FOA prioritize fully developed programs or early exploratory work?
It prioritizes early-stage, exploratory projects intended to generate new mechanistic insights and proof-of-concept findings, consistent with the R21 mechanism.
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