Opportunity Information: Apply for RFA AG 10 002
Apply for RFA AG 10 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alzheimers Disease Research Centers (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Feb 20, 2009 and posted on Feb 20, 2009.
- Applicants must submit their applications by May 5, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $20,300,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The Alzheimers Disease Research Centers (P50) opportunity, Funding Opportunity Number RFA-AG-10-002, is a discretionary NIH grant announcement from the National Institute on Aging (NIA) aimed at building and sustaining comprehensive, institution-based research centers focused on Alzheimers disease and related disorders. The core idea is to support centers that can do more than run individual projects in isolation. NIA is looking for hubs that bring together multidisciplinary teams, shared infrastructure, and coordinated research programs to accelerate progress in understanding disease mechanisms, improving diagnosis, and developing prevention and treatment strategies. These centers are also expected to help clarify what distinguishes Alzheimers and related dementias from normal brain aging and from mild cognitive impairment (MCI), which is often viewed as a transitional clinical state but can have varied outcomes and underlying biology.
The purpose of an ADRC under this announcement is both scientific and practical. On the scientific side, the centers should conduct and support cutting-edge research on Alzheimers disease and conditions that overlap with it clinically or biologically. On the practical side, they are meant to function as shared research resources for the broader research community by providing organized infrastructure, standardized approaches, and access to expertise, data, and potentially participant cohorts or specialized cores. NIA emphasizes that ADRCs should enable research that disentangles disease-specific processes from typical aging, which is crucial for developing accurate biomarkers, staging tools, and clinical criteria that can be used consistently across studies and, eventually, clinical settings.
A major theme of the announcement is translation: turning research findings into better real-world tools and strategies. That includes improved diagnostic approaches, earlier detection methods, prevention strategies, and therapeutic development. Because AD research often requires integration across clinical research, imaging, pathology, genetics, epidemiology, and computational methods, the center model is designed to support that integration by creating a stable platform where multiple projects can share resources and coordinate methods. The FOA also explicitly highlights the development of novel techniques and methodologies, signaling that NIA values centers that not only apply existing tools but also push the field forward by creating and validating new research approaches.
Training and workforce development are also built into the rationale for these centers. The ADRCs are expected to provide a platform for training investigators and staff in Alzheimers-related research, helping build the next generation of researchers who can work across disciplines. In practice, this typically means structured opportunities for junior investigators, mentorship, and an environment where trainees can engage with shared cores, standardized datasets, and collaborative projects that expose them to the full pipeline from basic discovery through clinical and translational work.
In terms of funding structure, this opportunity uses the NIH P50 mechanism, which generally supports specialized center grants with multiple integrated components and shared cores. The FOA notes that it runs in parallel with a separate announcement of identical scientific scope, RFA-AG-10-001, which uses the P30 mechanism. The parallel posting signals that NIA is supporting the same overall scientific mission through two related center grant structures, likely to accommodate different institutional needs or center configurations while keeping the scientific expectations aligned.
For fiscal year 2010, NIA planned to commit about 20.3 million dollars in total costs to support an anticipated 9 to 11 awards. The announcement indicates these awards could include new grants and/or competing continuation grants, meaning both new center applications and existing centers competing for renewed funding were within scope. The listed award ceiling is 1,000,000 dollars, and the opportunity does not require cost sharing or matching.
Eligibility is broad and includes a range of higher education and nonprofit institutions. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofits both with and without 501(c)(3) status (with the nonprofit eligibility categories explicitly excluding institutions of higher education where applicable). The FOA also calls out additional eligible applicant types to encourage participation from institutions that serve historically underrepresented communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. Overall, the eligibility language suggests NIA intended ADRCs to be housed at qualified institutions capable of sustaining complex center operations and multidisciplinary research programs, while also encouraging diversity in the institutional landscape that contributes to AD research.
Key administrative details are as follows: the opportunity was posted February 20, 2009, with an original and current closing date of May 5, 2009, and an archive date of June 5, 2009. The CFDA number associated with the program is 93.866 (Aging Research). The sponsoring agency is the National Institutes of Health, specifically the National Institute on Aging. A full announcement was made available through the NIH Grants Guide at the link provided in the source information, and NIH Office of Extramural Research web support contacts were listed for access and technical issues.
In short, RFA-AG-10-002 funds Alzheimers Disease Research Centers that combine coordinated research projects with shared resources and training capacity, with a strong emphasis on distinguishing disease from normal aging and MCI and on translating discoveries into improved diagnosis, prevention, and treatment. The P50 mechanism is intended to support robust, integrated center programs, and NIA planned a substantial multi-award investment to maintain a national network of high-capacity AD research hubs.
Frequently Asked Questions (FAQs)
What is the funding opportunity RFA-AG-10-002?
RFA-AG-10-002 is an NIH discretionary funding opportunity from the National Institute on Aging (NIA) to support Alzheimer's Disease Research Centers (ADRCs) using the P50 Specialized Center grant mechanism. It is designed to build and sustain comprehensive, institution-based research centers focused on Alzheimer's disease and related disorders.
What is the main goal of an Alzheimer's Disease Research Center (ADRC) under this FOA?
The main goal is to support centers that function as coordinated hubs rather than isolated projects. ADRCs are expected to unite multidisciplinary teams, shared infrastructure, and integrated research programs to accelerate progress in understanding disease mechanisms, improving diagnosis, and developing prevention and treatment strategies.
What kinds of research activities are ADRCs expected to support?
ADRCs are expected to conduct and support cutting-edge research on Alzheimer's disease and conditions that overlap clinically or biologically with it. The FOA emphasizes coordinated programs that can advance understanding of mechanisms, diagnostics, prevention approaches, and therapeutic development, including the development and validation of novel techniques and methodologies.
Why does the FOA emphasize distinguishing Alzheimer's disease from normal aging and MCI?
NIA highlights the need to disentangle disease-specific processes from typical brain aging and from mild cognitive impairment (MCI). MCI is often viewed as a transitional clinical state but can have varied outcomes and underlying biology. Clarifying these distinctions is framed as important for developing accurate biomarkers, staging tools, and consistent clinical criteria across studies and eventual clinical use.
What does the FOA mean by a "center model" rather than separate individual projects?
The center model is meant to support integration across multiple disciplines (for example, clinical research, imaging, pathology, genetics, epidemiology, and computational methods) through shared resources and coordinated methods. The intent is to create a stable platform where multiple research components can work together and share infrastructure.
How does this opportunity support translation to real-world impact?
The FOA places a strong emphasis on translation, including turning research findings into improved diagnostic approaches, earlier detection methods, prevention strategies, and therapeutic development.
Are ADRCs expected to serve as shared resources for other researchers?
Yes. ADRCs are described as shared research resources for the broader research community by providing organized infrastructure, standardized approaches, and access to expertise, data, and potentially participant cohorts or specialized cores.
Does the FOA include expectations related to training and workforce development?
Yes. Training and workforce development are part of the rationale. ADRCs are expected to provide a platform for training investigators and staff in Alzheimer's-related research, helping develop the next generation of researchers who can work across disciplines. The FOA description points to structured opportunities for junior investigators, mentorship, and an environment that exposes trainees to shared cores, standardized datasets, and collaborative projects.
What grant mechanism is used for this ADRC opportunity?
This opportunity uses the NIH P50 mechanism, which generally supports specialized center grants with multiple integrated components and shared cores.
Is there a related or parallel funding announcement with the same scientific scope?
Yes. The FOA notes it runs in parallel with RFA-AG-10-001, which has identical scientific scope but uses the P30 mechanism. The parallel announcements indicate NIA support for the same mission through two related center structures.
How much funding did NIA plan to commit, and how many awards were anticipated?
For fiscal year 2010, NIA planned to commit about $20.3 million in total costs and anticipated making 9 to 11 awards.
What is the listed award ceiling for this opportunity?
The listed award ceiling is $1,000,000.
Does this funding opportunity require cost sharing or matching funds?
No. The opportunity does not require cost sharing or matching.
Were both new centers and renewals eligible to apply?
Yes. The FOA indicates the awards could include new grants and/or competing continuation grants, meaning both new center applications and existing centers applying for renewed funding were within scope.
Who is eligible to apply for RFA-AG-10-002?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations with or without 501(c)(3) status (with the nonprofit eligibility categories explicitly excluding institutions of higher education where applicable).
Does the FOA encourage applications from institutions serving underrepresented communities?
Yes. The FOA explicitly calls out Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions as eligible applicant types, reflecting an intent to encourage participation from institutions that serve historically underrepresented communities.
Which agency and institute sponsor this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), specifically the National Institute on Aging (NIA).
What is the CFDA number associated with this program?
The CFDA number is 93.866, listed as Aging Research.
When was the opportunity posted, and what were the key dates?
The opportunity was posted on February 20, 2009. The original and current closing date was May 5, 2009, and the archive date was June 5, 2009.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide at the link referenced in the source information for this opportunity.
Who was listed for technical or access support?
NIH Office of Extramural Research web support contacts were listed for access and technical issues.
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